Gene Review:
ABCC5 - ATP-binding cassette, sub-family C...
Homo sapiens
Synonyms:
ABC33, ATP-binding cassette sub-family C member 5, EST277145, MOAT-C, MOATC, ...
Niimi,
Guo,
Yamakido,
Katoh,
Suzuki,
Nies,
Isobe,
Bessho,
Oguri,
Achiwa,
Assaraf,
Rea,
Muramatsu,
Takano,
Tanabe,
Büchler,
Martignoni,
Kruh,
Dantzig,
Pratt,
Keppler,
Starling,
König,
Chen,
Lee,
Ueda,
Nishio,
Liu,
Nishio,
Friess,
Maeda,
Sato,
Suzuki,
Perry,
Hartel,
Chen,
Zeng,
Fujiwara,
Oguri,
Belinsky,
Miyazaki,
- ABCC drug efflux pumps and organic anion uptake transporters in human gliomas and the blood-tumor barrier. Bronger, H., König, J., Kopplow, K., Steiner, H.H., Ahmadi, R., Herold-Mende, C., Keppler, D., Nies, A.T. Cancer Res. (2005)
- Expression and localization of human multidrug resistance protein (ABCC) family members in pancreatic carcinoma. König, J., Hartel, M., Nies, A.T., Martignoni, M.E., Guo, J., Büchler, M.W., Friess, H., Keppler, D. Int. J. Cancer (2005)
- The MRP family and anticancer drug metabolism. Suzuki, T., Nishio, K., Tanabe, S. Curr. Drug Metab. (2001)
- Multidrug-resistance protein 5 is a multispecific organic anion transporter able to transport nucleotide analogs. Wijnholds, J., Mol, C.A., van Deemter, L., de Haas, M., Scheffer, G.L., Baas, F., Beijnen, J.H., Scheper, R.J., Hatse, S., De Clercq, E., Balzarini, J., Borst, P. Proc. Natl. Acad. Sci. U.S.A. (2000)
- Immunolocalization of multidrug resistance protein 5 in the human genitourinary system. Nies, A.T., Spring, H., Thon, W.F., Keppler, D., Jedlitschky, G. J. Urol. (2002)
- Characterization of MOAT-C and MOAT-D, new members of the MRP/cMOAT subfamily of transporter proteins. Belinsky, M.G., Bain, L.J., Balsara, B.B., Testa, J.R., Kruh, G.D. J. Natl. Cancer Inst. (1998)
- ATP binding cassette multidrug transporters limit the anti-HIV activity of zidovudine and indinavir in infected human macrophages. Jorajuria, S., Dereuddre-Bosquet, N., Becher, F., Martin, S., Porcheray, F., Garrigues, A., Mabondzo, A., Benech, H., Grassi, J., Orlowski, S., Dormont, D., Clayette, P. Antivir. Ther. (Lond.) (2004)
- The determinants of sensitivity and acquired resistance to gemcitabine differ in non-small cell lung cancer: a role of ABCC5 in gemcitabine sensitivity. Oguri, T., Achiwa, H., Sato, S., Bessho, Y., Takano, Y., Miyazaki, M., Muramatsu, H., Maeda, H., Niimi, T., Ueda, R. Mol. Cancer Ther. (2006)
- Induction of MRP5 and SMRP mRNA by adriamycin exposure and its overexpression in human lung cancer cells resistant to adriamycin. Yoshida, M., Suzuki, T., Komiya, T., Hatashita, E., Nishio, K., Kazuhiko, N., Fukuoka, M. Int. J. Cancer (2001)
- Increased expression of the MRP5 gene is associated with exposure to platinum drugs in lung cancer. Oguri, T., Isobe, T., Suzuki, T., Nishio, K., Fujiwara, Y., Katoh, O., Yamakido, M. Int. J. Cancer (2000)
- Role of MRP4 and MRP5 in biology and chemotherapy. Sampath, J., Adachi, M., Hatse, S., Naesens, L., Balzarini, J., Flatley, R.M., Matherly, L.H., Schuetz, J.D. AAPS PharmSci (2002)
- Kinetic validation of the use of carboxydichlorofluorescein as a drug surrogate for MRP5-mediated transport. Pratt, S., Chen, V., Perry, W.I., Starling, J.J., Dantzig, A.H. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. (2006)
- Reconstitution of ATP-dependent cGMP transport into proteoliposomes by membrane proteins from human erythrocytes. Boadu, E., Sager, G. Scand. J. Clin. Lab. Invest. (2004)
- Expression, localization, and function of MRP5 (ABCC5), a transporter for cyclic nucleotides, in human placenta and cultured human trophoblasts: effects of gestational age and cellular differentiation. Meyer Zu Schwabedissen, H.E., Grube, M., Heydrich, B., Linnemann, K., Fusch, C., Kroemer, H.K., Jedlitschky, G. Am. J. Pathol. (2005)
- cGMP transport by vesicles from human and mouse erythrocytes. de Wolf, C.J., Yamaguchi, H., van der Heijden, I., Wielinga, P.R., Hundscheid, S.L., Ono, N., Scheffer, G.L., de Haas, M., Schuetz, J.D., Wijnholds, J., Borst, P. FEBS J. (2007)
- Multidrug resistance protein (MRP) 4- and MRP 5-mediated efflux of 9-(2-phosphonylmethoxyethyl)adenine by microglia. Dallas, S., Schlichter, L., Bendayan, R. J. Pharmacol. Exp. Ther. (2004)
- pABC11 (also known as MOAT-C and MRP5), a member of the ABC family of proteins, has anion transporter activity but does not confer multidrug resistance when overexpressed in human embryonic kidney 293 cells. McAleer, M.A., Breen, M.A., White, N.L., Matthews, N. J. Biol. Chem. (1999)
- Immuno-histochemical detection of MRPs in human lung cells in culture. Torky, A.R., Stehfest, E., Viehweger, K., Taege, C., Foth, H. Toxicology (2005)
- The role of multidrug resistance efflux transporters in antifolate resistance and folate homeostasis. Assaraf, Y.G. Drug Resist. Updat. (2006)
- Strong linkage disequilibrium at the nucleotide analogue transporter ABCC5 gene locus. Gwee, P.C., Tang, K., Sew, P.H., Lee, E.J., Chong, S.S., Lee, C.G. Pharmacogenet. Genomics (2005)
- MRP subfamily transporters and resistance to anticancer agents. Kruh, G.D., Zeng, H., Rea, P.A., Liu, G., Chen, Z.S., Lee, K., Belinsky, M.G. J. Bioenerg. Biomembr. (2001)
- Hyaluronan export by the ABC transporter MRP5 and its modulation by intracellular cGMP. Schulz, T., Schumacher, U., Prehm, P. J. Biol. Chem. (2007)
- Analysis of expression of cMOAT (MRP2), MRP3, MRP4, and MRP5, homologues of the multidrug resistance-associated protein gene (MRP1), in human cancer cell lines. Kool, M., de Haas, M., Scheffer, G.L., Scheper, R.J., van Eijk, M.J., Juijn, J.A., Baas, F., Borst, P. Cancer Res. (1997)
- Two new genes from the human ATP-binding cassette transporter superfamily, ABCC11 and ABCC12, tandemly duplicated on chromosome 16q12. Tammur, J., Prades, C., Arnould, I., Rzhetsky, A., Hutchinson, A., Adachi, M., Schuetz, J.D., Swoboda, K.J., Ptácek, L.J., Rosier, M., Dean, M., Allikmets, R. Gene (2001)
- Multidrug resistance-associated proteins: Export pumps for conjugates with glutathione, glucuronate or sulfate. Homolya, L., Váradi, A., Sarkadi, B. Biofactors (2003)
- Expression of multidrug resistance protein-related genes in lung cancer: correlation with drug response. Young, L.C., Campling, B.G., Voskoglou-Nomikos, T., Cole, S.P., Deeley, R.G., Gerlach, J.H. Clin. Cancer Res. (1999)
- Expression and localization of the multidrug resistance protein 5 (MRP5/ABCC5), a cellular export pump for cyclic nucleotides, in human heart. Dazert, P., Meissner, K., Vogelgesang, S., Heydrich, B., Eckel, L., Böhm, M., Warzok, R., Kerb, R., Brinkmann, U., Schaeffeler, E., Schwab, M., Cascorbi, I., Jedlitschky, G., Kroemer, H.K. Am. J. Pathol. (2003)
- Characterization of the transport of nucleoside analog drugs by the human multidrug resistance proteins MRP4 and MRP5. Reid, G., Wielinga, P., Zelcer, N., De Haas, M., Van Deemter, L., Wijnholds, J., Balzarini, J., Borst, P. Mol. Pharmacol. (2003)