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Gene Review

TRAP1  -  TNF receptor-associated protein 1

Homo sapiens

Synonyms: HSP 75, HSP75, HSP90L, Heat shock protein 75 kDa, mitochondrial, TNFR-associated protein 1, ...
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Disease relevance of TRAP1


High impact information on TRAP1


Biological context of TRAP1


Anatomical context of TRAP1


Associations of TRAP1 with chemical compounds

  • In addition, TRAP1 exhibited ATPase activity that was inhibited by both geldanamycin and radicicol [16].
  • Involvement of tumor necrosis factor receptor-associated protein 1 (TRAP1) in apoptosis induced by beta-hydroxyisovalerylshikonin [1].
  • The suppression of the level of TRAP1 by either beta-HIVS or VP16 was blocked by N-acetyl-cysteine, indicating the involvement of reactive oxygen species (ROS) in the regulation of the expression of TRAP1 [1].
  • After in vitro transcription/translation and 35S labeling, TRAP-1 was precipitated using a fusion protein consisting of glutathione S-transferase and TNFR-1IC, showing that the two proteins directly interact [12].
  • These effects were abrogated by hindrance of physical platelet-endothelial contacts using transwell systems or inhibited by GRGDSP, mAbs anti-GP IIb/IIIa (7E3), anti-alpha(v)beta3 (LM609), or anti-CD40L (TRAP1) [17].

Physical interactions of TRAP1

  • The ability of deletion mutants of TNFR-1 to interact with TRAP-1 was tested using the two hybrid system [12].
  • The inhibitory mutant has no TNFR-associated factor 2-binding capabilities and inhibits the recruitment of TNFR-associated factor 2 to the CD40 signaling complex after stimulation [18].

Regulatory relationships of TRAP1

  • Herpesvirus entry mediator, a member of the tumor necrosis factor receptor (TNFR) family, interacts with members of the TNFR-associated factor family and activates the transcription factors NF-kappaB and AP-1 [19].
  • Specifically, pro-inflammatory genes such as TNFalpha, IL-1beta, and MCP-1/MCAF-1 were down-regulated and anti-inflammatory genes such as TRAP1 and SMAD4 were induced [20].
  • TICAM1 activates NF-kappaB through two different pathways involving its interactions with TNFR-associated factor 6 and receptor-interacting protein 1 [21].
  • In Paracentrotus lividus embryos the inducible forms of HSP70 (HSP70/72) are different in molecular mass from the constitutively expressed HSP75, and they can be used as markers of cellular stress [22].

Other interactions of TRAP1


Analytical, diagnostic and therapeutic context of TRAP1

  • Immunofluorescence data show that human TRAP1 is localized to mitochondria [16].
  • In this study, we performed cDNA array analysis and found that beta-HIVS suppressed the expression of the gene for tumor necrosis factor receptor-associated protein 1 (TRAP1), which is a member of the heat-shock family of proteins [1].
  • Western blot analysis of purified rat liver mitochondrial subfractions with the TRAP-1 antibody reveals that the cross-reactive protein (M(r) approximately 80 kDa) is mainly present in the matrix compartment [27].
  • We have used quantitative immunogold electron microscopy and biochemical analysis to evaluate the subcellular distribution of TRAP-1 in rat tissues [27].
  • Immunoelectron microscopy provides evidence that tumor necrosis factor receptor-associated protein 1 (TRAP-1) is a mitochondrial protein which also localizes at specific extramitochondrial sites [27].


  1. Involvement of tumor necrosis factor receptor-associated protein 1 (TRAP1) in apoptosis induced by beta-hydroxyisovalerylshikonin. Masuda, Y., Shima, G., Aiuchi, T., Horie, M., Hori, K., Nakajo, S., Kajimoto, S., Shibayama-Imazu, T., Nakaya, K. J. Biol. Chem. (2004) [Pubmed]
  2. The Epstein-Barr virus transforming protein LMP1 engages signaling proteins for the tumor necrosis factor receptor family. Mosialos, G., Birkenbach, M., Yalamanchili, R., VanArsdale, T., Ware, C., Kieff, E. Cell (1995) [Pubmed]
  3. A Preferential Role for STAT5, not Constitutively Active STAT3, in Promoting Survival of a Human Lymphoid Tumor. Nagy, Z.S., Rui, H., Stepkowski, S.M., Karras, J., Kirken, R.A. J. Immunol. (2006) [Pubmed]
  4. A new versatile and robust mite trap for detection and monitoring of storage mites in the cereal and allied industries. Thind, B.B. Exp. Appl. Acarol. (2005) [Pubmed]
  5. Downregulation of TNF receptor-associated protein-2/p97 in renal cell carcinoma. Stassar, M.J., Pitzer, C., Zøller, M. Oncol. Res. (1999) [Pubmed]
  6. Two tumour necrosis factor receptors: structure and function. Vandenabeele, P., Declercq, W., Beyaert, R., Fiers, W. Trends Cell Biol. (1995) [Pubmed]
  7. Severe TNF receptor-associated periodic syndrome due to 2 TNFRSF1A mutations including a new F60V substitution. Haas, S.L., Lohse, P., Schmitt, W.H., Hildenbrand, R., Karaorman, M., Singer, M.V., Böcker, U. Gastroenterology (2006) [Pubmed]
  8. IL-1 receptor-associated kinase 1 is critical for latent membrane protein 1-induced p65/RelA serine 536 phosphorylation and NF-kappaB activation. Song, Y.J., Jen, K.Y., Soni, V., Kieff, E., Cahir-McFarland, E. Proc. Natl. Acad. Sci. U.S.A. (2006) [Pubmed]
  9. Cardiac glycosides inhibit TNF-alpha/NF-kappaB signaling by blocking recruitment of TNF receptor-associated death domain to the TNF receptor. Yang, Q., Huang, W., Jozwik, C., Lin, Y., Glasman, M., Caohuy, H., Srivastava, M., Esposito, D., Gillette, W., Hartley, J., Pollard, H.B. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  10. Expression analysis with oligonucleotide microarrays reveals that MYC regulates genes involved in growth, cell cycle, signaling, and adhesion. Coller, H.A., Grandori, C., Tamayo, P., Colbert, T., Lander, E.S., Eisenman, R.N., Golub, T.R. Proc. Natl. Acad. Sci. U.S.A. (2000) [Pubmed]
  11. The HSP90 family of genes in the human genome: insights into their divergence and evolution. Chen, B., Piel, W.H., Gui, L., Bruford, E., Monteiro, A. Genomics (2005) [Pubmed]
  12. Identification of a protein with homology to hsp90 that binds the type 1 tumor necrosis factor receptor. Song, H.Y., Dunbar, J.D., Zhang, Y.X., Guo, D., Donner, D.B. J. Biol. Chem. (1995) [Pubmed]
  13. Two-hybrid cloning of a gene encoding TNF receptor-associated protein 2, a protein that interacts with the intracellular domain of the type 1 TNF receptor: identity with subunit 2 of the 26S protease. Dunbar, J.D., Song, H.Y., Guo, D., Wu, L.W., Donner, D.B. J. Immunol. (1997) [Pubmed]
  14. A new role for FcgammaRIIA in the potentiation of human platelet activation induced by weak stimulation. Canobbio, I., Stefanini, L., Guidetti, G.F., Balduini, C., Torti, M. Cell. Signal. (2006) [Pubmed]
  15. Iron chelation study in a normal human hepatocyte cell line suggests that tumor necrosis factor receptor-associated protein 1 (TRAP1) regulates production of reactive oxygen species. Im, C.N., Lee, J.S., Zheng, Y., Seo, J.S. J. Cell. Biochem. (2007) [Pubmed]
  16. The hsp90-related protein TRAP1 is a mitochondrial protein with distinct functional properties. Felts, S.J., Owen, B.A., Nguyen, P., Trepel, J., Donner, D.B., Toft, D.O. J. Biol. Chem. (2000) [Pubmed]
  17. Engagement of glycoprotein IIb/IIIa (alpha(IIb)beta3) on platelets upregulates CD40L and triggers CD40L-dependent matrix degradation by endothelial cells. May, A.E., Kälsch, T., Massberg, S., Herouy, Y., Schmidt, R., Gawaz, M. Circulation (2002) [Pubmed]
  18. Characterization of a CD40-dominant inhibitory receptor mutant. Mehl, A.M., Jones, M., Rowe, M., Brennan, P. J. Immunol. (2001) [Pubmed]
  19. Herpesvirus entry mediator, a member of the tumor necrosis factor receptor (TNFR) family, interacts with members of the TNFR-associated factor family and activates the transcription factors NF-kappaB and AP-1. Marsters, S.A., Ayres, T.M., Skubatch, M., Gray, C.L., Rothe, M., Ashkenazi, A. J. Biol. Chem. (1997) [Pubmed]
  20. Immunomodulatory and transcriptional effects of progesterone through progesterone A and B receptors in Hec50co poorly differentiated endometrial cancer cells. Davies, S., Dai, D., Wolf, D.M., Leslie, K.K. J. Soc. Gynecol. Investig. (2004) [Pubmed]
  21. Evidence for Evolving Toll-IL-1 Receptor-Containing Adaptor Molecule Function in Vertebrates. Sullivan, C., Postlethwait, J.H., Lage, C.R., Millard, P.J., Kim, C.H. J. Immunol. (2007) [Pubmed]
  22. Nickel, lead, and cadmium induce differential cellular responses in sea urchin embryos by activating the synthesis of different HSP70s. Geraci, F., Pinsino, A., Turturici, G., Savona, R., Giudice, G., Sconzo, G. Biochem. Biophys. Res. Commun. (2004) [Pubmed]
  23. Increased sensitivity of T lymphocytes to tumor necrosis factor receptor 1 (TNFR1)- and TNFR2-mediated apoptosis in HIV infection: relation to expression of Bcl-2 and active caspase-8 and caspase-3. de Oliveira Pinto, L.M., Garcia, S., Lecoeur, H., Rapp, C., Gougeon, M.L. Blood (2002) [Pubmed]
  24. Cooperation between TNF Receptor-Associated Factors 1 and 2 in CD40 Signaling. Xie, P., Hostager, B.S., Munroe, M.E., Moore, C.R., Bishop, G.A. J. Immunol. (2006) [Pubmed]
  25. Early events in TNF signaling: a story of associations and dissociations. Darnay, B.G., Aggarwal, B.B. J. Leukoc. Biol. (1997) [Pubmed]
  26. Induction of tumour necrosis factor receptor-expressing macrophages by interleukin-10 and macrophage colony-stimulating factor in rheumatoid arthritis. Takasugi, K., Yamamura, M., Iwahashi, M., Otsuka, F., Yamana, J., Sunahori, K., Kawashima, M., Yamada, M., Makino, H. Arthritis Res. Ther. (2006) [Pubmed]
  27. Immunoelectron microscopy provides evidence that tumor necrosis factor receptor-associated protein 1 (TRAP-1) is a mitochondrial protein which also localizes at specific extramitochondrial sites. Cechetto, J.D., Gupta, R.S. Exp. Cell Res. (2000) [Pubmed]
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