Gene Review:
MSLN - mesothelin
Homo sapiens
Synonyms:
CAK1, CAK1 antigen, MPF, Mesothelin, Pre-pro-megakaryocyte-potentiating factor, ...
- Molecular cloning of mesothelin, a differentiation antigen present on mesothelium, mesotheliomas, and ovarian cancers. Chang, K., Pastan, I. Proc. Natl. Acad. Sci. U.S.A. (1996)
- Humoral immune response to mesothelin in mesothelioma and ovarian cancer patients. Ho, M., Hassan, R., Zhang, J., Wang, Q.C., Onda, M., Bera, T., Pastan, I. Clin. Cancer Res. (2005)
- Mesothelin: a new target for immunotherapy. Hassan, R., Bera, T., Pastan, I. Clin. Cancer Res. (2004)
- Large-scale molecular and tissue microarray analysis of mesothelin expression in common human carcinomas. Frierson, H.F., Moskaluk, C.A., Powell, S.M., Zhang, H., Cerilli, L.A., Stoler, M.H., Cathro, H., Hampton, G.M. Hum. Pathol. (2003)
- Physical activity and sleeping metabolic rate. Westerterp, K.R., Meijer, G.A., Saris, W.H., Soeters, P.B., Winants, Y., ten Hoor, F. Medicine and science in sports and exercise. (1991)
- Usefulness of mortality data in determining the geography and time trends of dementia. Martyn, C.N., Pippard, E.C. Journal of epidemiology and community health. (1988)
- Mental retardation in teenagers: prevalence data from the Niagara region, Ontario. Bradley, E.A., Thompson, A., Bryson, S.E. Canadian journal of psychiatry. Revue canadienne de psychiatrie. (2002)
- Mortality of a cohort of men in a silicosis register: further evidence of an association with lung cancer. Ng, T.P., Chan, S.L., Lee, J. Am. J. Ind. Med. (1990)
- EEG biofeedback of low beta band components: frequency-specific effects on variables of attention and event-related brain potentials. Egner, T., Gruzelier, J.H. Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology. (2004)
- Mutations of phosphorylation sites in lamin A that prevent nuclear lamina disassembly in mitosis. Heald, R., McKeon, F. Cell (1990)
- Identification of cell cycle-regulated phosphorylation sites on nuclear lamin C. Ward, G.E., Kirschner, M.W. Cell (1990)
- Purification of MPF from starfish: identification as the H1 histone kinase p34cdc2 and a possible mechanism for its periodic activation. Labbe, J.C., Picard, A., Peaucellier, G., Cavadore, J.C., Nurse, P., Doree, M. Cell (1989)
- Polo-like kinase 1 phosphorylates cyclin B1 and targets it to the nucleus during prophase. Toyoshima-Morimoto, F., Taniguchi, E., Shinya, N., Iwamatsu, A., Nishida, E. Nature (2001)
- Cloning and expression of the recombinant FAb fragment of monoclonal antibody K1 that reacts with mesothelin present on mesotheliomas and ovarian cancers. Brinkmann, U., Webber, K., Di Carlo, A., Beers, R., Chowdhury, P., Chang, K., Chaudhary, V., Gallo, M., Pastan, I. Int. J. Cancer (1997)
- Mitosis-specific monoclonal antibody MPM-2 inhibits Xenopus oocyte maturation and depletes maturation-promoting activity. Kuang, J., Zhao, J., Wright, D.A., Saunders, G.F., Rao, P.N. Proc. Natl. Acad. Sci. U.S.A. (1989)
- Characterization of the antigen (CAK1) recognized by monoclonal antibody K1 present on ovarian cancers and normal mesothelium. Chang, K., Pai, L.H., Batra, J.K., Pastan, I., Willingham, M.C. Cancer Res. (1992)
- Mesothelin is overexpressed in pancreaticobiliary adenocarcinomas but not in normal pancreas and chronic pancreatitis. Hassan, R., Laszik, Z.G., Lerner, M., Raffeld, M., Postier, R., Brackett, D. Am. J. Clin. Pathol. (2005)
- Effects of thiopental (Trapanal) on coronary blood flow and myocardial metabolism in man. Sonntag, H., Hellberg, K., Schenk, H.D., Donath, U., Regensburger, D., Kettler, D., Duchanova, H., Larsen, R. Acta anaesthesiologica Scandinavica. (1975)
- Characterization of human mesothelin transcripts in ovarian and pancreatic cancer. Muminova, Z.E., Strong, T.V., Shaw, D.R. BMC Cancer (2004)
- Mesothelin-mediated targeting of adenoviral vectors for ovarian cancer gene therapy. Breidenbach, M., Rein, D.T., Everts, M., Glasgow, J.N., Wang, M., Passineau, M.J., Alvarez, R.D., Korokhov, N., Curiel, D.T. Gene Ther. (2005)
- Development of a CA125-mesothelin cell adhesion assay as a screening tool for biologics discovery. Scholler, N., Garvik, B., Hayden-Ledbetter, M., Kline, T., Urban, N. Cancer Lett. (2007)
- Mesothelin-MUC16 binding is a high affinity, N-glycan dependent interaction that facilitates peritoneal metastasis of ovarian tumors. Gubbels, J.A., Belisle, J., Onda, M., Rancourt, C., Migneault, M., Ho, M., Bera, T.K., Connor, J., Sathyanarayana, B.K., Lee, B., Pastan, I., Patankar, M.S. Mol. Cancer (2006)
- Frequent expression of the tumor antigen CAK1 in squamous-cell carcinomas. Chang, K., Pastan, I., Willingham, M.C. Int. J. Cancer (1992)
- Cell-cycle related regulation of poly(A) polymerase by phosphorylation. Colgan, D.F., Murthy, K.G., Prives, C., Manley, J.L. Nature (1996)
- Mesothelin-specific CD8(+) T cell responses provide evidence of in vivo cross-priming by antigen-presenting cells in vaccinated pancreatic cancer patients. Thomas, A.M., Santarsiero, L.M., Lutz, E.R., Armstrong, T.D., Chen, Y.C., Huang, L.Q., Laheru, D.A., Goggins, M., Hruban, R.H., Jaffee, E.M. J. Exp. Med. (2004)
- Protein kinase CK2 is involved in G2 arrest and apoptosis following spindle damage in epithelial cells. Sayed, M., Pelech, S., Wong, C., Marotta, A., Salh, B. Oncogene (2001)
- Components of the signaling pathway linking the 1-methyladenine receptor to MPF activation and maturation in starfish oocytes. Sadler, K.C., Ruderman, J.V. Dev. Biol. (1998)
- Okadaic acid overrides the S-phase check point and accelerates progression of G2-phase to induce premature mitosis in HeLa cells. Ghosh, S., Schroeter, D., Paweletz, N. Exp. Cell Res. (1996)
- Isolation and characterization of a monoclonal antibody, K1, reactive with ovarian cancers and normal mesothelium. Chang, K., Pastan, I., Willingham, M.C. Int. J. Cancer (1992)
- The diagnostic utility of immunohistochemistry in distinguishing between mesothelioma and renal cell carcinoma: a comparative study. Ordóñez, N.G. Hum. Pathol. (2004)
- Immunohistochemistry can help distinguish metastatic pancreatic adenocarcinomas from bile duct adenomas and hamartomas of the liver. Hornick, J.L., Lauwers, G.Y., Odze, R.D. Am. J. Surg. Pathol. (2005)
- Forced expression of deltaN-TCF-1B in colon cancer derived cell lines is accompanied by the induction of CEACAM5/6 and mesothelin. Liebig, B., Brabletz, T., Staege, M.S., Wulfänger, J., Riemann, D., Burdach, S., Ballhausen, W.G. Cancer Lett. (2005)
- Detection and quantitation of serum mesothelin, a tumor marker for patients with mesothelioma and ovarian cancer. Hassan, R., Remaley, A.T., Sampson, M.L., Zhang, J., Cox, D.D., Pingpank, J., Alexander, R., Willingham, M., Pastan, I., Onda, M. Clin. Cancer Res. (2006)