Gene Review:
SPRY2 - sprouty homolog 2 (Drosophila)
Homo sapiens
Synonyms:
Protein sprouty homolog 2, Spry-2, hSPRY2
- Sprouty proteins regulate ureteric branching by coordinating reciprocal epithelial Wnt11, mesenchymal Gdnf and stromal Fgf7 signalling during kidney development. Chi, L., Zhang, S., Lin, Y., Prunskaite-Hyyryläinen, R., Vuolteenaho, R., Itäranta, P., Vainio, S. Development (2004)
- Epigenetic inactivation of the human sprouty2 (hSPRY2) homologue in prostate cancer. McKie, A.B., Douglas, D.A., Olijslagers, S., Graham, J., Omar, M.M., Heer, R., Gnanapragasam, V.J., Robson, C.N., Leung, H.Y. Oncogene (2005)
- Regulator of epidermal growth factor signaling: Sprouty. Wong, E.S., Guy, G.R. Methods Mol. Biol. (2006)
- Sprouty1 and Sprouty2 provide a control mechanism for the Ras/MAPK signalling pathway. Hanafusa, H., Torii, S., Yasunaga, T., Nishida, E. Nat. Cell Biol. (2002)
- Sprouty2 attenuates epidermal growth factor receptor ubiquitylation and endocytosis, and consequently enhances Ras/ERK signalling. Wong, E.S., Fong, C.W., Lim, J., Yusoff, P., Low, B.C., Langdon, W.Y., Guy, G.R. EMBO J. (2002)
- The bimodal regulation of epidermal growth factor signaling by human Sprouty proteins. Egan, J.E., Hall, A.B., Yatsula, B.A., Bar-Sagi, D. Proc. Natl. Acad. Sci. U.S.A. (2002)
- Sprouty regulates cell migration by inhibiting the activation of Rac1 GTPase. Poppleton, H.M., Edwin, F., Jaggar, L., Ray, R., Johnson, L.R., Patel, T.B. Biochem. Biophys. Res. Commun. (2004)
- Concomitant down-regulation of SPRY1 and SPRY2 in prostate carcinoma. Fritzsche, S., Kenzelmann, M., Hoffmann, M.J., Müller, M., Engers, R., Gröne, H.J., Schulz, W.A. Endocr. Relat. Cancer (2006)
- Regulation of sprouty stability by Mnk1-dependent phosphorylation. DaSilva, J., Xu, L., Kim, H.J., Miller, W.T., Bar-Sagi, D. Mol. Cell. Biol. (2006)
- The C terminus of sprouty is important for modulation of cellular migration and proliferation. Yigzaw, Y., Cartin, L., Pierre, S., Scholich, K., Patel, T.B. J. Biol. Chem. (2001)
- The tumor suppressor PTEN is necessary for human Sprouty 2-mediated inhibition of cell proliferation. Edwin, F., Singh, R., Endersby, R., Baker, S.J., Patel, T.B. J. Biol. Chem. (2006)
- Human SPRY2 inhibits FGF2 signalling by a secreted factor. Glienke, J., Fenten, G., Seemann, M., Sturz, A., Thierauch, K.H. Mech. Dev. (2000)
- Protein-tyrosine phosphatase-1B (PTP1B) mediates the anti-migratory actions of Sprouty. Yigzaw, Y., Poppleton, H.M., Sreejayan, N., Hassid, A., Patel, T.B. J. Biol. Chem. (2003)
- Sprouty proteins are targeted to membrane ruffles upon growth factor receptor tyrosine kinase activation. Identification of a novel translocation domain. Lim, J., Wong, E.S., Ong, S.H., Yusoff, P., Low, B.C., Guy, G.R. J. Biol. Chem. (2000)
- Direct Binding of PP2A to Sprouty2 and Phosphorylation Changes Are a Prerequisite for ERK Inhibition Downstream of Fibroblast Growth Factor Receptor Stimulation. Lao, D.H., Yusoff, P., Chandramouli, S., Philp, R.J., Fong, C.W., Jackson, R.A., Saw, T.Y., Yu, C.Y., Guy, G.R. J. Biol. Chem. (2007)
- FRS2-dependent SRC activation is required for fibroblast growth factor receptor-induced phosphorylation of Sprouty and suppression of ERK activity. Li, X., Brunton, V.G., Burgar, H.R., Wheldon, L.M., Heath, J.K. J. Cell. Sci. (2004)
- Tyrosine phosphorylation of Sprouty2 enhances its interaction with c-Cbl and is crucial for its function. Fong, C.W., Leong, H.F., Wong, E.S., Lim, J., Yusoff, P., Guy, G.R. J. Biol. Chem. (2003)
- Sprouty genes are expressed in osteoblasts and inhibit fibroblast growth factor-mediated osteoblast responses. Yang, X., Webster, J.B., Kovalenko, D., Nadeau, R.J., Zubanova, O., Chen, P.Y., Friesel, R. Calcif. Tissue Int. (2006)
- hSpry2 is targeted to the ubiquitin-dependent proteasome pathway by c-Cbl. Hall, A.B., Jura, N., DaSilva, J., Jang, Y.J., Gong, D., Bar-Sagi, D. Curr. Biol. (2003)
- Human placental Hofbauer cells express sprouty proteins: a possible modulating mechanism of villous branching. Anteby, E.Y., Natanson-Yaron, S., Greenfield, C., Goldman-Wohl, D., Haimov-Kochman, R., Holzer, H., Yagel, S. Placenta (2005)
- A Src Homology 3-binding Sequence on the C Terminus of Sprouty2 Is Necessary for Inhibition of the Ras/ERK Pathway Downstream of Fibroblast Growth Factor Receptor Stimulation. Lao, D.H., Chandramouli, S., Yusoff, P., Fong, C.W., Saw, T.Y., Tai, L.P., Yu, C.Y., Leong, H.F., Guy, G.R. J. Biol. Chem. (2006)
- Regulation of Sprouty2 stability by mammalian Seven-in-Absentia homolog 2. Nadeau, R.J., Toher, J.L., Yang, X., Kovalenko, D., Friesel, R. J. Cell. Biochem. (2007)
- Overexpression of sprouty 2 inhibits HGF/SF-mediated cell growth, invasion, migration, and cytokinesis. Lee, C.C., Putnam, A.J., Miranti, C.K., Gustafson, M., Wang, L.M., Vande Woude, G.F., Gao, C.F. Oncogene (2004)