Disease relevance of BCAS2

• This study suggested that BCAS2 might play an important role in breast cancer development by increasing the estrogen receptor's function [1].

High impact information on BCAS2

• Moreover, tumor-related proteins including breast carcinoma amplified sequence 2, zinc finger proteins, chromobox protein homologs were identified in individual cell lines [2].
• Transient transfection assays revealed that overexpression of BCAS2 enhanced while inhibition of BCAS2 expression attenuated the estrogen receptor-mediated transcription [1].
• Mouse DAM1 regulates pro-apoptotic activity of BLK in mammary epithelial cells [3].
• Previously we reported that BCAS2 gene is localized on chromosome 1p13.3-21 and is up-regulated by gene amplification in breast cancer cell lines MCF-7 and BT-20 [4].

Biological context of BCAS2

• Amplification of the BCAS2 gene at chromosome 1p13.3-21 in human primary breast cancer [4].

Anatomical context of BCAS2

• Breast cancer amplified sequence 2 (BCAS2) was initially identified as a gene that was overexpressed and amplified in some breast cancer cell lines [1].

Other interactions of BCAS2

• Here, we identified BCAS2 as an estrogen receptor (ER) alpha interacting protein by yeast two-hybrid screening [1].

Analytical, diagnostic and therapeutic context of BCAS2

• In this study, we investigated the amplification of the BCAS2 gene in a series of 104 gynecological primary tumors by means of Southern blot analysis [4].

References