Gene Review:
NMUR1 - neuromedin U receptor 1
Homo sapiens
Synonyms:
(FM-3), FM-3, FM3, G-protein coupled receptor 66, G-protein coupled receptor FM-3, ...
Szekeres,
Muir,
Spinage,
Miller,
Butler,
Smith,
Rennie,
Murdock,
Fitzgerald,
Wu,
McMillan,
Guerrera,
Vawter,
Elshourbagy,
Mooney,
Bergsma,
Wilson,
Chambers,
Kojima,
Haruno,
Nakazato,
Date,
Murakami,
Hanada,
Matsuo,
Kangawa,
Chen,
Higashikubo,
Laszlo,
Roti Roti,
Moriyama,
Fukuyama,
Inoue,
Matsumoto,
Sato,
Tanaka,
Kinjyo,
Kano,
Yoshimura,
Kojima,
Gartlon,
Szekeres,
Pullen,
Sarau,
Aiyar,
Shabon,
Michalovich,
Steplewski,
Ellis,
Elshourbagy,
Duxon,
Ashmeade,
Harrison,
Murdock,
Wilson,
Ennaceur,
Atkins,
Heidbreder,
Hagan,
Hunter,
Jones,
- Neuromedin U: a Myb-regulated autocrine growth factor for human myeloid leukemias. Shetzline, S.E., Rallapalli, R., Dowd, K.J., Zou, S., Nakata, Y., Swider, C.R., Kalota, A., Choi, J.K., Gewirtz, A.M. Blood (2004)
- TACE cleavage of proamphiregulin regulates GPCR-induced proliferation and motility of cancer cells. Gschwind, A., Hart, S., Fischer, O.M., Ullrich, A. EMBO J. (2003)
- A central role of EGF receptor transactivation in angiotensin II -induced cardiac hypertrophy. Shah, B.H., Catt, K.J. Trends Pharmacol. Sci. (2003)
- p90 ribosomal S6 kinase 2 exerts a tonic brake on G protein-coupled receptor signaling. Sheffler, D.J., Kroeze, W.K., Garcia, B.G., Deutch, A.Y., Hufeisen, S.J., Leahy, P., Brüning, J.C., Roth, B.L. Proc. Natl. Acad. Sci. U.S.A. (2006)
- E-selectin permits communication between PAF receptors and TRPC channels in human neutrophils. McMeekin, S.R., Dransfield, I., Rossi, A.G., Haslett, C., Walker, T.R. Blood (2006)
- Regulators of G protein signaling (RGS proteins): novel central nervous system drug targets. Neubig, R.R. J. Pept. Res. (2002)
- Emerging signalling and protein interactions mediated via metabotropic glutamate receptors. Moldrich, R.X., Beart, P.M. Current drug targets. CNS and neurological disorders. (2003)
- Rhodopsin: structural basis of molecular physiology. Menon, S.T., Han, M., Sakmar, T.P. Physiol. Rev. (2001)
- Cargo regulates clathrin-coated pit dynamics. Puthenveedu, M.A., von Zastrow, M. Cell (2006)
- A nuclear function of beta-arrestin1 in GPCR signaling: regulation of histone acetylation and gene transcription. Kang, J., Shi, Y., Xiang, B., Qu, B., Su, W., Zhu, M., Zhang, M., Bao, G., Wang, F., Zhang, X., Yang, R., Fan, F., Chen, X., Pei, G., Ma, L. Cell (2005)
- Beta-arrestin goes nuclear. Beaulieu, J.M., Caron, M.G. Cell (2005)
- Lysophosphatidic acid-induced squamous cell carcinoma cell proliferation and motility involves epidermal growth factor receptor signal transactivation. Gschwind, A., Prenzel, N., Ullrich, A. Cancer Res. (2002)
- Pleiotropic coupling of G protein-coupled receptors to the mitogen-activated protein kinase cascade. Role of focal adhesions and receptor tyrosine kinases. Della Rocca, G.J., Maudsley, S., Daaka, Y., Lefkowitz, R.J., Luttrell, L.M. J. Biol. Chem. (1999)
- The synthetic peptide derived from the NH2-terminal extracellular region of an orphan G protein-coupled receptor, GPR1, preferentially inhibits infection of X4 HIV-1. Jinno-Oue, A., Shimizu, N., Soda, Y., Tanaka, A., Ohtsuki, T., Kurosaki, D., Suzuki, Y., Hoshino, H. J. Biol. Chem. (2005)
- Differential regulation of estrogen receptor alpha, glucocorticoid receptor and retinoic acid receptor alpha transcriptional activity by melatonin is mediated via different G proteins. Kiefer, T.L., Lai, L., Yuan, L., Dong, C., Burow, M.E., Hill, S.M. J. Pineal Res. (2005)
- Involvement of metabotropic glutamate receptor 1, a G protein coupled receptor, in melanoma development. Marín, Y.E., Chen, S. J. Mol. Med. (2004)
- The neuromedin u-growth hormone secretagogue receptor 1b/neurotensin receptor 1 oncogenic signaling pathway as a therapeutic target for lung cancer. Takahashi, K., Furukawa, C., Takano, A., Ishikawa, N., Kato, T., Hayama, S., Suzuki, C., Yasui, W., Inai, K., Sone, S., Ito, T., Nishimura, H., Tsuchiya, E., Nakamura, Y., Daigo, Y. Cancer Res. (2006)
- Post-translational proteolytic processing of the calcium-independent receptor of alpha-latrotoxin (CIRL), a natural chimera of the cell adhesion protein and the G protein-coupled receptor. Role of the G protein-coupled receptor proteolysis site (GPS) motif. Krasnoperov, V., Lu, Y., Buryanovsky, L., Neubert, T.A., Ichtchenko, K., Petrenko, A.G. J. Biol. Chem. (2002)
- Identification of neuromedin U as the cognate ligand of the orphan G protein-coupled receptor FM-3. Fujii, R., Hosoya, M., Fukusumi, S., Kawamata, Y., Habata, Y., Hinuma, S., Onda, H., Nishimura, O., Fujino, M. J. Biol. Chem. (2000)
- The neuropeptide neuromedin U activates eosinophils and is involved in allergen-induced eosinophilia. Moriyama, M., Fukuyama, S., Inoue, H., Matsumoto, T., Sato, T., Tanaka, K., Kinjyo, I., Kano, T., Yoshimura, A., Kojima, M. Am. J. Physiol. Lung Cell Mol. Physiol. (2006)
- Localisation of NMU1R and NMU2R in human and rat central nervous system and effects of neuromedin-U following central administration in rats. Gartlon, J., Szekeres, P., Pullen, M., Sarau, H.M., Aiyar, N., Shabon, U., Michalovich, D., Steplewski, K., Ellis, C., Elshourbagy, N., Duxon, M., Ashmeade, T.E., Harrison, D.C., Murdock, P., Wilson, S., Ennaceur, A., Atkins, A., Heidbreder, C., Hagan, J.J., Hunter, A.J., Jones, D.N. Psychopharmacology (Berl.) (2004)
- Neuromedin U stimulates contraction of human long saphenous vein and gastrointestinal smooth muscle in vitro. Jones, N.A., Morton, M.F., Prendergast, C.E., Powell, G.L., Shankley, N.P., Hollingsworth, S.J. Regul. Pept. (2006)
- Neuromedin U is a potent agonist at the orphan G protein-coupled receptor FM3. Szekeres, P.G., Muir, A.I., Spinage, L.D., Miller, J.E., Butler, S.I., Smith, A., Rennie, G.I., Murdock, P.R., Fitzgerald, L.R., Wu, H., McMillan, L.J., Guerrera, S., Vawter, L., Elshourbagy, N.A., Mooney, J.L., Bergsma, D.J., Wilson, S., Chambers, J.K. J. Biol. Chem. (2000)
- Regulation of gonadotropin secretion and puberty onset by neuromedin U. Fukue, Y., Sato, T., Teranishi, H., Hanada, R., Takahashi, T., Nakashima, Y., Kojima, M. FEBS Lett. (2006)
- Identification of a novel neuromedin U receptor subtype expressed in the central nervous system. Shan, L., Qiao, X., Crona, J.H., Behan, J., Wang, S., Laz, T., Bayne, M., Gustafson, E.L., Monsma, F.J., Hedrick, J.A. J. Biol. Chem. (2000)
- Neuromedin s as novel putative regulator of luteinizing hormone secretion. Vigo, E., Roa, J., López, M., Castellano, J.M., Fernandez-Fernandez, R., Navarro, V.M., Pineda, R., Aguilar, E., Diéguez, C., Pinilla, L., Tena-Sempere, M. Endocrinology (2007)
- Ocular albinism: evidence for a defect in an intracellular signal transduction system. Schiaffino, M.V., d'Addio, M., Alloni, A., Baschirotto, C., Valetti, C., Cortese, K., Puri, C., Bassi, M.T., Colla, C., De Luca, M., Tacchetti, C., Ballabio, A. Nat. Genet. (1999)
- Receptor-tyrosine-kinase- and G beta gamma-mediated MAP kinase activation by a common signalling pathway. van Biesen, T., Hawes, B.E., Luttrell, D.K., Krueger, K.M., Touhara, K., Porfiri, E., Sakaue, M., Luttrell, L.M., Lefkowitz, R.J. Nature (1995)
- Regulation of tyrosine kinase cascades by G-protein-coupled receptors. Luttrell, L.M., Daaka, Y., Lefkowitz, R.J. Curr. Opin. Cell Biol. (1999)
- Purification and identification of neuromedin U as an endogenous ligand for an orphan receptor GPR66 (FM3). Kojima, M., Haruno, R., Nakazato, M., Date, Y., Murakami, N., Hanada, R., Matsuo, H., Kangawa, K. Biochem. Biophys. Res. Commun. (2000)
- Identification and functional characterization of a novel subtype of neuromedin U receptor. Hosoya, M., Moriya, T., Kawamata, Y., Ohkubo, S., Fujii, R., Matsui, H., Shintani, Y., Fukusumi, S., Habata, Y., Hinuma, S., Onda, H., Nishimura, O., Fujino, M. J. Biol. Chem. (2000)
- Multiple alternative splicing forms of human RAD17 and their differential response to ionizing radiation. Chen, M.S., Higashikubo, R., Laszlo, A., Roti Roti, J. Gene (2001)
- G protein-coupled receptors: functional and mechanistic insights through altered gene expression. Rohrer, D.K., Kobilka, B.K. Physiol. Rev. (1998)
- A second leukotriene B(4) receptor, BLT2. A new therapeutic target in inflammation and immunological disorders. Yokomizo, T., Kato, K., Terawaki, K., Izumi, T., Shimizu, T. J. Exp. Med. (2000)
- Techniques: GPCR assembly, pharmacology and screening by flow cytometry. Waller, A., Simons, P.C., Biggs, S.M., Edwards, B.S., Prossnitz, E.R., Sklar, L.A. Trends Pharmacol. Sci. (2004)
- Trace amines: identification of a family of mammalian G protein-coupled receptors. Borowsky, B., Adham, N., Jones, K.A., Raddatz, R., Artymyshyn, R., Ogozalek, K.L., Durkin, M.M., Lakhlani, P.P., Bonini, J.A., Pathirana, S., Boyle, N., Pu, X., Kouranova, E., Lichtblau, H., Ochoa, F.Y., Branchek, T.A., Gerald, C. Proc. Natl. Acad. Sci. U.S.A. (2001)
- The beta2-adrenergic receptor/betaarrestin complex recruits the clathrin adaptor AP-2 during endocytosis. Laporte, S.A., Oakley, R.H., Zhang, J., Holt, J.A., Ferguson, S.S., Caron, M.G., Barak, L.S. Proc. Natl. Acad. Sci. U.S.A. (1999)