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Gene Review: 

ABCA8  -  ATP-binding cassette, sub-family A (ABC1),...

Homo sapiens

Synonyms: ATP-binding cassette sub-family A member 8, KIAA0822, MGC163152
 
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High impact information on ABCA8

  • Although ABCA7 and ABCA8 expression was relatively low in all cells, the highest expression occurred in microglia and neurons, respectively [1].
  • We examined the transport capacity in Xenopus laevis oocytes of human EST KIAA0822/ABCA8, a member of the ABC superfamily [2].
  • The deduced mouse ABCA8a protein is 66% identical with that of human ABCA8 and possesses features common to the ABC superfamily [3].
  • The results suggest that ABCA8 may play a role in digoxin metabolism in the liver [3].
 

Analytical, diagnostic and therapeutic context of ABCA8

  • We further evaluated the effect of acute digoxin (a substrate for ABCA8) intoxication on the mRNA expression of ABCA8 using northern blotting with a 3' non-coding region as a probe to avoid cross-hybridization with other ABCA genes [3].

References

  1. Quantitation of ATP-binding cassette subfamily-A transporter gene expression in primary human brain cells. Kim, W.S., Guillemin, G.J., Glaros, E.N., Lim, C.K., Garner, B. Neuroreport (2006)
  2. Functional analysis of ABCA8, a new drug transporter. Tsuruoka, S., Ishibashi, K., Yamamoto, H., Wakaumi, M., Suzuki, M., Schwartz, G.J., Imai, M., Fujimura, A. Biochem. Biophys. Res. Commun. (2002)
  3. Acute digoxin loading reduces ABCA8A mRNA expression in the mouse liver. Wakaumi, M., Ishibashi, K., Ando, H., Kasanuki, H., Tsuruoka, S. Clin. Exp. Pharmacol. Physiol. (2005)
 

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