Gene Review:
WFDC2 - WAP four-disulfide core domain 2
Homo sapiens
Synonyms:
EDDM4, Epididymal secretory protein E4, HE4, Major epididymis-specific protein E4, WAP four-disulfide core domain protein 2, ...
- The HE4 (WFDC2) protein is a biomarker for ovarian carcinoma. Hellström, I., Raycraft, J., Hayden-Ledbetter, M., Ledbetter, J.A., Schummer, M., McIntosh, M., Drescher, C., Urban, N., Hellström, K.E. Cancer Res. (2003)
- WFDC2 (HE4): a potential role in the innate immunity of the oral cavity and respiratory tract and the development of adenocarcinomas of the lung. Bingle, L., Cross, S.S., High, A.S., Wallace, W.A., Rassl, D., Yuan, G., Hellstrom, I., Campos, M.A., Bingle, C.D. Respir. Res. (2006)
- Human epididymis protein 4 (HE4) is a secreted glycoprotein that is overexpressed by serous and endometrioid ovarian carcinomas. Drapkin, R., von Horsten, H.H., Lin, Y., Mok, S.C., Crum, C.P., Welch, W.R., Hecht, J.L. Cancer Res. (2005)
- The putative ovarian tumour marker gene HE4 (WFDC2), is expressed in normal tissues and undergoes complex alternative splicing to yield multiple protein isoforms. Bingle, L., Singleton, V., Bingle, C.D. Oncogene (2002)
- Rodent epididymal cDNAs identified by sequence homology to human and canine counterparts. Kappler-Hanno, K., Kirchhoff, C. Asian J. Androl. (2003)
- Bead-based ELISA for validation of ovarian cancer early detection markers. Scholler, N., Crawford, M., Sato, A., Drescher, C.W., O'Briant, K.C., Kiviat, N., Anderson, G.L., Urban, N. Clin. Cancer Res. (2006)
- The involvement of the benzodiazepine receptor in hepatic encephalopathy: evidence for the presence of a benzodiazepine receptor ligand. Basile, A.S., Ostrowski, N.L., Gammal, S.H., Jones, E.A., Skolnick, P. Adv. Biochem. Psychopharmacol. (1990)
- Tissue-specific gene expression as an indicator of epididymis-specific functional status in the boar, bull and stallion. Uhlenbruck, F., Sinowatz, F., Amselgruber, W., Kirchhoff, C., Ivell, R. Int. J. Androl. (1993)
- Microarray profiling of progesterone-regulated endometrial genes during the rhesus monkey secretory phase. Ace, C.I., Okulicz, W.C. Reprod. Biol. Endocrinol. (2004)
- A major human epididymis-specific cDNA encodes a protein with sequence homology to extracellular proteinase inhibitors. Kirchhoff, C., Habben, I., Ivell, R., Krull, N. Biol. Reprod. (1991)
- Comprehensive analysis of HE4 expression in normal and malignant human tissues. Galgano, M.T., Hampton, G.M., Frierson, H.F. Mod. Pathol. (2006)
- Transcriptional targeting in ovarian cancer cells using the human epididymis protein 4 promoter. Berry, N.B., Cho, Y.M., Harrington, M.A., Williams, S.D., Foley, J., Nephew, K.P. Gynecol. Oncol. (2004)