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ACAA2  -  acetyl-CoA acyltransferase 2

Homo sapiens

Synonyms: 3-ketoacyl-CoA thiolase, mitochondrial, Acetyl-CoA acyltransferase, Beta-ketothiolase, DSAEC, Mitochondrial 3-oxoacyl-CoA thiolase, ...
 
 
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Disease relevance of ACAA2

 

Psychiatry related information on ACAA2

  • In contrast, within the CG, paternal parenting stress was negatively associated with adaptive parenting at T1 but showed no enduring negative effects in longitudinal analyses [6].
  • For both groups, there was a direct positive association between T1 use utility and T2 alcohol consumption and an indirect association with T2 alcohol problems via alcohol consumption [7].
 

High impact information on ACAA2

  • T1 measurements revealed high rates of motion for PIs relative to cholesterol in similar membrane hosts and revealed correlation times close to the fatty acyl methyl termini in phosphatidylcholine [8].
  • S-Mevalonate exhibited first-order kinetics with a T 1/2 of 19 to 23 min, while R-mevalonate kinetics could be resolved into two phases with half-lives of 9 and 42 min [9].
  • The results indicate that T1 and T2 share a common leader exon indicative of alternative splicing, and that the genes are uninterrupted by introns in their respective coding sequences [10].
  • Database interrogations also reveal a combined 297 hits of Rtdpoz-like sequences on 7 chromosomes; however, the bulk of the hits (264) and 26 putative TDPOZ-encoding genes, including T1 and T2, are found in a approximately 2.5 Mb cluster in the Rn2_2148 supercontig on chromosome 2 [10].
  • There was no correlation between T1 relaxation times and creatine/phosphocreatine or choline containing compounds [2].
 

Chemical compound and disease context of ACAA2

 

Biological context of ACAA2

  • When the T2/T1 ratio was calculated, there was no overlap between the heterozygotes and normal controls [13].
  • Peptide T1 is phosphorylated in isolated adipocytes, but this phosphorylation is not altered by insulin or TPA [14].
  • None of the GST M1 or GST T1 genotypes were significantly associated with the presence of RP among studied VCM workers [15].
  • The time frame from the bombardment of embryogenic callus to the harvesting of transgenic T1 seeds was 29 weeks and 25 weeks for the diploid and two tetraploid accessions used, respectively [16].
  • Red cell survival (51Cr T1/2) was shortened (15 days) [17].
 

Anatomical context of ACAA2

  • Immunotitration of AACoAT activity with antibodies against T2, CT, or T1 was carried out in control fibroblasts, with the following results [18].
  • Marked prolongation of T1 relaxation time correlates with enlargement of the extracellular space, which occurs as a result of axonal loss or oedema [19].
  • The thiolase activities and T2/T1 proteins in immunoblotting were detectable in peripheral lymphocytes, rectal mucosa, amniocytes, and liver [13].
  • Our results show that exposure to a whole-body average specific absorption rate (SAR) of 2 W/kg, 2 h/day for 4 consecutive weeks does not affect the frequencies of differentiating transitional 1 (T1) and T2 B cells or those of mature follicular B and marginal zone B cells in the spleen [20].
  • CONCLUSION: T1 and T2 in the basal ganglia of premature infants do not differ much from previously published data from basal ganglia of older children and adults [21].
 

Associations of ACAA2 with chemical compounds

  • After correcting for T1 and T2 losses, creatine content was significantly lower in white matter than gray (P < 0.01, t-test), with a white/gray content ratio of 0.8, in agreement with biopsy and in vivo measurements at 1.5 and 2.0T [22].
  • T1 relaxation time correlated significantly with both tNAA (r=-0.8, p < 0.001) and Ins (r=0.5, p=0. 012) [2].
  • Strain T1 is a facultative bacterium that is capable of anaerobic toluene degradation under denitrifying conditions [23].
  • We present evidence that beta-ketothiolase deficiency is not simply a defect of isoleucine degradation; the deficient enzyme is the K+ dependent short-chain mitochondrial thiolase, which also plays a major catalytic role in ketone body and fatty acid oxidation [24].
  • Three complexing agents and a thiolated resin were tested for their ability to reduce the T 1/2 of methylmercury in blood during an outbreak of human poisoning [25].
 

Other interactions of ACAA2

 

Analytical, diagnostic and therapeutic context of ACAA2

References

  1. 3-hydroxy-3-methylglutaryl-coenzyme A synthase reaction intermediates: detection of a covalent tetrahedral adduct by differential isotope shift 13C nuclear magnetic resonance spectroscopy. Vinarov, D.A., Miziorko, H.M. Biochemistry (2000) [Pubmed]
  2. Lesion heterogeneity in multiple sclerosis: a study of the relations between appearances on T1 weighted images, T1 relaxation times, and metabolite concentrations. Brex, P.A., Parker, G.J., Leary, S.M., Molyneux, P.D., Barker, G.J., Davie, C.A., Thompson, A.J., Miller, D.H. J. Neurol. Neurosurg. Psychiatr. (2000) [Pubmed]
  3. Beta-ketothiolase genes in Azotobacter vinelandii. Segura, D., Vargas, E., Espín, G. Gene (2000) [Pubmed]
  4. Effect of glutathione S-transferase M1 polymorphisms on biomarkers of exposure and effects. Srám, R.J. Environ. Health Perspect. (1998) [Pubmed]
  5. Competition between beta-ketothiolase and citrate synthase during poly(beta-hydroxybutyrate) synthesis in Methylobacterium rhodesianum. Mothes, G., Rivera, I.S., Babel, W. Arch. Microbiol. (1996) [Pubmed]
  6. Predictors of Parenting Behavior Trajectories Among Families of Young Adolescents with and without Spina Bifida. Greenley, R.N., Holmbeck, G.N., Rose, B.M. Journal of pediatric psychology (2006) [Pubmed]
  7. An affective and cognitive model of marijuana and alcohol problems. Simons, J.S., Carey, K.B. Addictive behaviors. (2006) [Pubmed]
  8. 2H NMR investigation of the organization and dynamics of polyisoprenols in membranes. de Ropp, J.S., Troy, F.A. J. Biol. Chem. (1985) [Pubmed]
  9. Metabolism of plasma mevalonate in rats and humans. Kopito, R.R., Weinstock, S.B., Freed, L.E., Murray, D.M., Brunengraber, H. J. Lipid Res. (1982) [Pubmed]
  10. Testis-specific expression and genomic multiplicity of the rat Rtdpoz genes that encode bipartite TRAF- and POZ/BTB-domain proteins. Choo, K.B., Hsu, M.C., Chong, K.Y., Huang, C.J. Gene (2007) [Pubmed]
  11. 1H chemical shift imaging characterization of human brain tumor and edema. Sijens, P.E., Oudkerk, M. European radiology. (2002) [Pubmed]
  12. Magnetic resonance imaging and spectroscopy in hepatic encephalopathy. Gupta, R.K., Dhiman, R.K. Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology. (2003) [Pubmed]
  13. Biochemical and immunochemical study of seven families with 3-ketothiolase deficiency: diagnosis of heterozygotes using immunochemical determination of the ratio of mitochondrial acetoacetyl-CoA thiolase and 3-ketoacyl-CoA thiolase proteins. Yamaguchi, S., Sakai, A., Fukao, T., Wakazono, A., Kuwahara, T., Orii, T., Hashimoto, T. Pediatr. Res. (1993) [Pubmed]
  14. Insulin and phorbol ester stimulate phosphorylation of acetyl-CoA carboxylase at similar sites in isolated adipocytes. Lack of correspondence with sites phosphorylated on the purified enzyme by protein kinase C. Haystead, T.A., Hardie, D.G. Eur. J. Biochem. (1988) [Pubmed]
  15. Glutathione S-transferase M1 and GST T1 genetic polymorphisms and Raynaud's phenomenon in French vinyl chloride monomer-exposed workers. Fontana, L., Marion, M.J., Ughetto, S., Catilina, P. J. Hum. Genet. (2006) [Pubmed]
  16. A rapid and efficient transformation protocol for the grass Brachypodium distachyon. Christiansen, P., Andersen, C.H., Didion, T., Folling, M., Nielsen, K.K. Plant Cell Rep. (2005) [Pubmed]
  17. Decreased sodium influx and abnormal red cell membrane lipids in a patient with familial plasma lecithin: cholesterol acyltransferase deficiency. Murayama, N., Asano, Y., Hosoda, S., Maesawa, M., Saito, M., Takaku, F., Sugihara, T., Miyashima, K., Yawata, Y. Am. J. Hematol. (1984) [Pubmed]
  18. Immunotitration analysis of cytosolic acetoacetyl-coenzyme A thiolase activity in human fibroblasts. Fukao, T., Song, X.Q., Yamaguchi, S., Hashimoto, T., Orii, T., Kondo, N. Pediatr. Res. (1996) [Pubmed]
  19. Characterization of tissue damage in multiple sclerosis by nuclear magnetic resonance. Barkhof, F., van Walderveen, M. Philos. Trans. R. Soc. Lond., B, Biol. Sci. (1999) [Pubmed]
  20. Effects of GSM-modulated radiofrequency electromagnetic fields on B-cell peripheral differentiation and antibody production. Nasta, F., Prisco, M.G., Pinto, R., Lovisolo, G.A., Marino, C., Pioli, C. Radiat. Res. (2006) [Pubmed]
  21. Proton spectroscopic metabolite signal relaxation times in preterm infants: a prerequisite for quantitative spectroscopy in infant brain. Kugel, H., Roth, B., Pillekamp, F., Krüger, K., Schulte, O., von Gontard, A., Benz-Bohm, G. Journal of magnetic resonance imaging : JMRI. (2003) [Pubmed]
  22. Evaluation of cerebral gray and white matter metabolite differences by spectroscopic imaging at 4.1T. Hetherington, H.P., Mason, G.F., Pan, J.W., Ponder, S.L., Vaughan, J.T., Twieg, D.B., Pohost, G.M. Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine. (1994) [Pubmed]
  23. Metabolites formed during anaerobic transformation of toluene and o-xylene and their proposed relationship to the initial steps of toluene mineralization. Evans, P.J., Ling, W., Goldschmidt, B., Ritter, E.R., Young, L.Y. Appl. Environ. Microbiol. (1992) [Pubmed]
  24. Acetoacetyl CoA thiolase deficiency: a cause of severe ketoacidosis in infancy simulating salicylism. Robinson, B.H., Sherwood, W.G., Taylor, J., Balfe, J.W., Mamer, O.A. J. Pediatr. (1979) [Pubmed]
  25. Tests of efficacy of antidotes for removal of methylmercury in human poisoning during the Iraq outbreak. Clarkson, T.W., Magos, L., Cox, C., Greenwood, M.R., Amin-Zaki, L., Majeed, M.A., Al-Damluji, S.F. J. Pharmacol. Exp. Ther. (1981) [Pubmed]
  26. Inborn errors of isoleucine degradation: A review. Korman, S.H. Mol. Genet. Metab. (2006) [Pubmed]
  27. Comparative frequency and severity of hypoglycemia in selected organic acidemias, branched chain amino acidemia, and disorders of fructose metabolism. Worthen, H.G., al Ashwal, A., Ozand, P.T., Garawi, S., Rahbeeni, Z., al Odaib, A., Subramanyam, S.B., Rashed, M. Brain Dev. (1994) [Pubmed]
  28. Characterization of new diagnostic acylcarnitines in patients with beta-ketothiolase deficiency and glutaric aciduria type I using mass spectrometry. Millington, D.S., Roe, C.R., Maltby, D.A. Biomed. Environ. Mass Spectrom. (1987) [Pubmed]
  29. Cloning and sequence analysis of a full length cDNA encoding human mitochondrial 3-oxoacyl-CoA thiolase. Abe, H., Ohtake, A., Yamamoto, S., Satoh, Y., Takayanagi, M., Amaya, Y., Takiguchi, M., Sakuraba, H., Suzuki, Y., Mori, M. Biochim. Biophys. Acta (1993) [Pubmed]
  30. Purification and properties of beta-ketothiolase from Zoogloea ramigera. Nishimura, T., Saito, T., Tomita, K. Arch. Microbiol. (1978) [Pubmed]
  31. Androgen regulation of prostate cancer cell FGF-1, FGF-2, and FGF-8: preferential down-regulation of FGF-2 transcripts. Sarić, T., Shain, S.A. Growth Factors (1998) [Pubmed]
  32. Variations of the melanocortin-1 receptor and the glutathione-S transferase T1 and M1 genes in cutaneous malignant melanoma. M??ssner, R., Anders, N., K??nig, I.R., Kr??ger, U., Schmidt, D., Berking, C., Ziegler, A., Brockm??ller, J., Kaiser, R., Volkenandt, M., Westphal, G.A., Reich, K. Arch. Dermatol. Res. (2007) [Pubmed]
 
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