Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Gene: CDX4 - caudal type homeobox 4

Homo sapiens

Synonyms: Caudal-type homeobox protein 4, caudal type homeobox transcription factor 4, Homeobox protein CDX-4

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Bansal, D., Simmler, M.C., Keenan, I.D.

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Disease relevance of CDX4

We report here that CDX4 is expressed normally in early hematopoietic progenitors and is expressed aberrantly in approximately 25% of acute myeloid leukemia (AML) patient samples [1].
Inasmuch as many human leukemias show dysregulated expression of a spectrum of HOX family members, these collective findings also suggest a central role for CDX4 expression in the genesis of acute leukemia [1].

High impact information on CDX4

Cdx4 regulates Hox gene expression in the adult murine hematopoietic system and dysregulates Hox genes that are implicated in leukemogenesis [1].
Cdx4 dysregulates Hox gene expression and generates acute myeloid leukemia alone and in cooperation with Meis1a in a murine model [1].
Coexpression of the Hox cofactor Meis1a accelerates the Cdx4 AML phenotype and renders it fully penetrant [1].
Together, these data indicate that Cdx4 regulates Hox gene expression in adult hematopoiesis and may serve as an upstream regulator of Hox gene expression in the induction of acute leukemia [1].
Furthermore, bone marrow progenitors that are retrovirally engineered to express Cdx4 serially replate in methylcellulose cultures, grow in liquid culture, and generate a partially penetrant, long-latency AML in bone marrow transplant recipients [1].

Biological context of CDX4

Structure-function analysis demonstrates that leukemic transformation requires intact Cdx4 transactivation and DNA-binding domains but not the putative Pbx cofactor interaction motif [1].

Anatomical context of CDX4

In the amphibian Xenopus laevis the earliest expression of Cdx1, Cdx2 and Cdx4 is within the developing mesoderm [2].

Other interactions of CDX4

Localisation of BRX, its human homolog has shown the gene to be located within the orthologous but inverted human CDX4-XIST segment [3].

References

Cdx4 dysregulates Hox gene expression and generates acute myeloid leukemia alone and in cooperation with Meis1a in a murine model. Bansal, D., Scholl, C., Fr??hling, S., McDowell, E., Lee, B.H., D??hner, K., Ernst, P., Davidson, A.J., Daley, G.Q., Zon, L.I., Gilliland, D.G., Huntly, B.J. Proc. Natl. Acad. Sci. U.S.A. (2006)
FGF signal transduction and the regulation of Cdx gene expression. Keenan, I.D., Sharrard, R.M., Isaacs, H.V. Dev. Biol. (2006)
Localization and expression analysis of a novel conserved brain expressed transcript, Brx/BRX, lying within the Xic/XIC candidate region. Simmler, M.C., Heard, E., Rougeulle, C., Cruaud, C., Weissenbach, J., Avner, P. Mamm. Genome (1997)