Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Gene Review:

CAP2 - CAP, adenylate cyclase-associated protein,...

Homo sapiens

Tublitz, N.J., Yu, G., Loi, P.K., Oya, M., Hawkins, V.

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Disease relevance of CAP2

Based on data from cobalt backfills and anti-CAP immunohistochemical staining, we propose that CAP2 exerts its effect on the larval hindgut at wandering via a local release from CAP-containing neurones in the terminal ganglion that project directly to the hindgut [1].

High impact information on CAP2

Prostate ESTs are assembled into distinct species groups using the multiple alignment program CAP2 and are annotated with information from the GenBank, dbEST and Unigene public sequence databases [2].
Expression of either human CAP or CAP2 in S. cerevisiae cap- strains suppresses phenotypes associated with deletion of the C-terminal domain of CAP, but does not restore hyper-activation of adenylyl cyclase by RAS2val19 [3].
We provide several lines of evidence that this CAP2 drop is regulated by the insect steroid hormone 20-hydroxyecdysone (20-HE) [4].
In larvae, the LNCs express high levels of a myoregulatory peptide, cardioacceleratory peptide 2 (CAP2) [4].
Measurements of the amount of CAP2 in the central nervous system (CNS) of fifth-instar caterpillars revealed that CAP2 storage levels declined sharply on the day of gut emptying [1].

Biological context of CAP2

Similarly, expression of either human CAP or CAP2 in S. pombe cap- strains suppresses the morphological and temperature-sensitive phenotypes associated with deletion of the C-terminal domain of CAP in this yeast [3].
These two CAP bands of lysosomal origin appeared in sera of pregnant women at different times during the course of gestation; CAP1 band in the 3rd month and CAP2 band in the 6th month [5].

Anatomical context of CAP2

The other two cystine aminopeptidase bands (CAP1 and CAP2), characteristic of pregnancy, were demonstrated in lysosomal extracts and hence suggested to be derived from the lysosomes of the placenta [5].

Associations of CAP2 with chemical compounds

The CAP2 decline in the LNCs could be directly induced by exogenous steroid application, but only under conditions where the LNCs remained connected to the brain [4].

Analytical, diagnostic and therapeutic context of CAP2

CAP2, when applied at physiological concentrations to an in vitro larval hindgut bioassay, caused changes in several parameters, including contraction frequency and amplitude, and basal tension [1].

References

Insect cardioactive peptides: regulation of hindgut activity by cardioacceleratory peptide 2 (CAP2) during wandering behaviour in Manduca sexta larvae. Tublitz, N.J., Allen, A.T., Cheung, C.C., Edwards, K.K., Kimble, D.P., Loi, P.K., Sylwester, A.W. J. Exp. Biol. (1992)
PEDB: the Prostate Expression Database. Hawkins, V., Doll, D., Bumgarner, R., Smith, T., Abajian, C., Hood, L., Nelson, P.S. Nucleic Acids Res. (1999)
Comparison of human CAP and CAP2, homologs of the yeast adenylyl cyclase-associated proteins. Yu, G., Swiston, J., Young, D. J. Cell. Sci. (1994)
Hormonal control of transmitter plasticity in insect peptidergic neurons. I. Steroid regulation of the decline in cardioacceleratory peptide 2 (CAP2) expression. Loi, P.K., Tublitz, N.J. J. Exp. Biol. (1993)
Demonstration of placental aminopeptidase isozymes by disc electrophoresis and its application to the forensic pregnancy test from blood stains. Oya, M., Yoshino, M., Mizutani, S. Forensic science. (1975)