Gene Review:
PROCR - protein C receptor, endothelial
Homo sapiens
Synonyms:
APC receptor, Activated protein C receptor, CCCA, CCD41, CD201, ...
- Expression and anticoagulant function of the endothelial cell protein C receptor (EPCR) in cancer cell lines. Tsuneyoshi, N., Fukudome, K., Horiguchi, S., Ye, X., Matsuzaki, M., Toi, M., Suzuki, K., Kimoto, M. Thromb. Haemost. (2001)
- Inherited abnormalities in the protein C activation pathway. España, F., Medina, P., Navarro, S., Estellés, A., Aznar, J. Pathophysiol. Haemost. Thromb. (2002)
- Activated protein C mediates novel lung endothelial barrier enhancement: role of sphingosine 1-phosphate receptor transactivation. Finigan, J.H., Dudek, S.M., Singleton, P.A., Chiang, E.T., Jacobson, J.R., Camp, S.M., Ye, S.Q., Garcia, J.G. J. Biol. Chem. (2005)
- Influence of the 4600A/G and 4678G/C polymorphisms in the endothelial protein C receptor (EPCR) gene on the risk of venous thromboembolism in carriers of factor V Leiden. Medina, P., Navarro, S., Estellés, A., Vayá, A., Bertina, R.M., España, F. Thromb. Haemost. (2005)
- Prevalence of a 23bp insertion in exon 3 of the endothelial cell protein C receptor gene in venous thrombophilia. von Depka, M., Czwalinna, A., Eisert, R., Wermes, C., Scharrer, I., Ganser, A., Ehrenforth, S. Thromb. Haemost. (2001)
- Activated protein C blocks p53-mediated apoptosis in ischemic human brain endothelium and is neuroprotective. Cheng, T., Liu, D., Griffin, J.H., Fernández, J.A., Castellino, F., Rosen, E.D., Fukudome, K., Zlokovic, B.V. Nat. Med. (2003)
- Activation mechanism of anticoagulant protein C in large blood vessels involving the endothelial cell protein C receptor. Fukudome, K., Ye, X., Tsuneyoshi, N., Tokunaga, O., Sugawara, K., Mizokami, H., Kimoto, M. J. Exp. Med. (1998)
- Identification of functional endothelial protein C receptor in human plasma. Kurosawa, S., Stearns-Kurosawa, D.J., Hidari, N., Esmon, C.T. J. Clin. Invest. (1997)
- Human protein C receptor is present primarily on endothelium of large blood vessels: implications for the control of the protein C pathway. Laszik, Z., Mitro, A., Taylor, F.B., Ferrell, G., Esmon, C.T. Circulation (1997)
- Identification of the protein C/activated protein C binding sites on the endothelial cell protein C receptor. Implications for a novel mode of ligand recognition by a major histocompatibility complex class 1-type receptor. Liaw, P.C., Mather, T., Oganesyan, N., Ferrell, G.L., Esmon, C.T. J. Biol. Chem. (2001)
- Identification, cloning, and regulation of a novel endothelial cell protein C/activated protein C receptor. Fukudome, K., Esmon, C.T. J. Biol. Chem. (1994)
- C-reactive protein decreases expression of thrombomodulin and endothelial protein C receptor in human endothelial cells. Nan, B., Yang, H., Yan, S., Lin, P.H., Lumsden, A.B., Yao, Q., Chen, C. Surgery (2005)
- Coagulation and inflammation. Esmon, C.T. J. Endotoxin Res. (2003)
- The endothelial cell protein C receptor (EPCR) functions as a primary receptor for protein C activation on endothelial cells in arteries, veins, and capillaries. Ye, X., Fukudome, K., Tsuneyoshi, N., Satoh, T., Tokunaga, O., Sugawara, K., Mizokami, H., Kimoto, M. Biochem. Biophys. Res. Commun. (1999)
- Human vascular smooth muscle cells express functionally active endothelial cell protein C receptor. Bretschneider, E., Uzonyi, B., Weber, A.A., Fischer, J.W., Pape, R., Lötzer, K., Schrör, K. Circ. Res. (2007)
- The endothelial cell protein C receptor augments protein C activation by the thrombin-thrombomodulin complex. Stearns-Kurosawa, D.J., Kurosawa, S., Mollica, J.S., Ferrell, G.L., Esmon, C.T. Proc. Natl. Acad. Sci. U.S.A. (1996)
- Reconstitution of the human endothelial cell protein C receptor with thrombomodulin in phosphatidylcholine vesicles enhances protein C activation. Xu, J., Esmon, N.L., Esmon, C.T. J. Biol. Chem. (1999)
- Metalloproteolytic release of endothelial cell protein C receptor. Xu, J., Qu, D., Esmon, N.L., Esmon, C.T. J. Biol. Chem. (2000)
- Recombinant human activated protein C upregulates cyclooxygenase-2 expression in endothelial cells via binding to endothelial cell protein C receptor and activation of protease-activated receptor-1. Brueckmann, M., Horn, S., Lang, S., Fukudome, K., Schulze Nahrup, A., Hoffmann, U., Kaden, J.J., Borggrefe, M., Haase, K.K., Huhle, G. Thromb. Haemost. (2005)
- Mechanisms by which soluble endothelial cell protein C receptor modulates protein C and activated protein C function. Liaw, P.C., Neuenschwander, P.F., Smirnov, M.D., Esmon, C.T. J. Biol. Chem. (2000)
- The anticoagulant protein C pathway. Dahlbäck, B., Villoutreix, B.O. FEBS Lett. (2005)
- The soluble endothelial protein C receptor binds to activated neutrophils: involvement of proteinase-3 and CD11b/CD18. Kurosawa, S., Esmon, C.T., Stearns-Kurosawa, D.J. J. Immunol. (2000)
- Anti-inflammatory effect of activated protein C in gastric epithelial cells. Nakamura, M., Gabazza, E.C., Imoto, I., Yano, Y., Taguchi, O., Horiki, N., Fukudome, K., Suzuki, K., Adachi, Y. J. Thromb. Haemost. (2005)
- The protein C pathway. Esmon, C.T. Chest (2003)
- Endothelial protein C receptor and protease-activated receptor-1 mediate induction of a wound-healing phenotype in human keratinocytes by activated protein C. Xue, M., Campbell, D., Sambrook, P.N., Fukudome, K., Jackson, C.J. J. Invest. Dermatol. (2005)
- The endothelial cell protein C receptor. Inhibition of activated protein C anticoagulant function without modulation of reaction with proteinase inhibitors. Regan, L.M., Stearns-Kurosawa, D.J., Kurosawa, S., Mollica, J., Fukudome, K., Esmon, C.T. J. Biol. Chem. (1996)