Gene Review:
SLCO1B1 - solute carrier organic anion transporter...
Homo sapiens
Synonyms:
HBLRR, LST-1, LST1, Liver-specific organic anion transporter 1, OATP-2, ...
Abe,
Unno,
Onogawa,
Tokui,
Kondo,
Nakagomi,
Adachi,
Fujiwara,
Okabe,
Suzuki,
Nunoki,
Sato,
Kakyo,
Nishio,
Sugita,
Asano,
Tanemoto,
Seki,
Date,
Ono,
Kondo,
Shiiba,
Suzuki,
Ohtani,
Shimosegawa,
Iinuma,
Nagura,
Ito,
Matsuno,
Hermann,
Bogsrud,
Molden,
Asberg,
Mohebi,
Ose,
Retterstøl,
Lennernäs,
Kivistö,
Niemi,
König,
Cui,
Nies,
Keppler,
Cui,
König,
Leier,
Buchholz,
Keppler,
- Hepatic uptake of bilirubin and its conjugates by the human organic anion transporter SLC21A6. Cui, Y., König, J., Leier, I., Buchholz, U., Keppler, D. J. Biol. Chem. (2001)
- Detection of the human organic anion transporters SLC21A6 (OATP2) and SLC21A8 (OATP8) in liver and hepatocellular carcinoma. Cui, Y., König, J., Nies, A.T., Pfannschmidt, M., Hergt, M., Franke, W.W., Alt, W., Moll, R., Keppler, D. Lab. Invest. (2003)
- A novel variant allele of OATP-C (SLCO1B1) found in a Japanese patient with pravastatin-induced myopathy. Morimoto, K., Oishi, T., Ueda, S., Ueda, M., Hosokawa, M., Chiba, K. Drug Metab. Pharmacokinet. (2004)
- Molecular characterization and functional regulation of a novel rat liver-specific organic anion transporter rlst-1. Kakyo, M., Unno, M., Tokui, T., Nakagomi, R., Nishio, T., Iwasashi, H., Nakai, D., Seki, M., Suzuki, M., Naitoh, T., Matsuno, S., Yawo, H., Abe, T. Gastroenterology (1999)
- LST-2, a human liver-specific organic anion transporter, determines methotrexate sensitivity in gastrointestinal cancers. Abe, T., Unno, M., Onogawa, T., Tokui, T., Kondo, T.N., Nakagomi, R., Adachi, H., Fujiwara, K., Okabe, M., Suzuki, T., Nunoki, K., Sato, E., Kakyo, M., Nishio, T., Sugita, J., Asano, N., Tanemoto, M., Seki, M., Date, F., Ono, K., Kondo, Y., Shiiba, K., Suzuki, M., Ohtani, H., Shimosegawa, T., Iinuma, K., Nagura, H., Ito, S., Matsuno, S. Gastroenterology (2001)
- Drug and bile acid transporters in rosuvastatin hepatic uptake: function, expression, and pharmacogenetics. Ho, R.H., Tirona, R.G., Leake, B.F., Glaeser, H., Lee, W., Lemke, C.J., Wang, Y., Kim, R.B. Gastroenterology (2006)
- Enterohepatic bile salt transporters in normal physiology and liver disease. Kullak-Ublick, G.A., Stieger, B., Meier, P.J. Gastroenterology (2004)
- Isolation of a multispecific organic anion and cardiac glycoside transporter from rat brain. Noé, B., Hagenbuch, B., Stieger, B., Meier, P.J. Proc. Natl. Acad. Sci. U.S.A. (1997)
- Involvement of organic anion transporting polypeptides in the transport of troglitazone sulfate: implications for understanding troglitazone hepatotoxicity. Nozawa, T., Sugiura, S., Nakajima, M., Goto, A., Yokoi, T., Nezu, J., Tsuji, A., Tamai, I. Drug Metab. Dispos. (2004)
- Uptake of enalapril and expression of organic anion transporting polypeptide 1 in zonal, isolated rat hepatocytes. Abu-Zahra, T.N., Wolkoff, A.W., Kim, R.B., Pang, K.S. Drug Metab. Dispos. (2000)
- Organic anion transporting polypeptide-C mediates arsenic uptake in HEK-293 cells. Lu, W.J., Tamai, I., Nezu, J., Lai, M.L., Huang, J.D. J. Biomed. Sci. (2006)
- Influence of drug transporter polymorphisms on pravastatin pharmacokinetics in humans. Kivist??, K.T., Niemi, M. Pharm. Res. (2007)
- Effect of SLCO1B1 polymorphism on induction of CYP3A4 by rifampicin. Niemi, M., Kivistö, K.T., Diczfalusy, U., Bodin, K., Bertilsson, L., Fromm, M.F., Eichelbaum, M. Pharmacogenet. Genomics (2006)
- Localization and genomic organization of a new hepatocellular organic anion transporting polypeptide. König, J., Cui, Y., Nies, A.T., Keppler, D. J. Biol. Chem. (2000)
- Transcellular transport of organic anions across a double-transfected Madin-Darby canine kidney II cell monolayer expressing both human organic anion-transporting polypeptide (OATP2/SLC21A6) and Multidrug resistance-associated protein 2 (MRP2/ABCC2). Sasaki, M., Suzuki, H., Ito, K., Abe, T., Sugiyama, Y. J. Biol. Chem. (2002)
- The human organic anion transport protein SLC21A6 is not sufficient for bilirubin transport. Wang, P., Kim, R.B., Chowdhury, J.R., Wolkoff, A.W. J. Biol. Chem. (2003)
- Characterization of the human OATP-C (SLC21A6) gene promoter and regulation of liver-specific OATP genes by hepatocyte nuclear factor 1 alpha. Jung, D., Hagenbuch, B., Gresh, L., Pontoglio, M., Meier, P.J., Kullak-Ublick, G.A. J. Biol. Chem. (2001)
- Active influx transport is mediated by members of the organic anion transporting polypeptide family in human epidermal keratinocytes. Schiffer, R., Neis, M., Höller, D., Rodríguez, F., Geier, A., Gartung, C., Lammert, F., Dreuw, A., Zwadlo-Klarwasser, G., Merk, H., Jugert, F., Baron, J.M. J. Invest. Dermatol. (2003)
- Organic anion-transporting polypeptides mediate transport of opioid peptides across blood-brain barrier. Gao, B., Hagenbuch, B., Kullak-Ublick, G.A., Benke, D., Aguzzi, A., Meier, P.J. J. Pharmacol. Exp. Ther. (2000)
- Characterization of the transport of the bicyclic peptide phalloidin by human hepatic transport proteins. Fehrenbach, T., Cui, Y., Faulstich, H., Keppler, D. Naunyn Schmiedebergs Arch. Pharmacol. (2003)
- Clinical pharmacokinetics of atorvastatin. Lennernäs, H. Clinical pharmacokinetics. (2003)
- Interactions of rifamycin SV and rifampicin with organic anion uptake systems of human liver. Vavricka, S.R., Van Montfoort, J., Ha, H.R., Meier, P.J., Fattinger, K. Hepatology (2002)
- Exposure of atorvastatin is unchanged but lactone and acid metabolites are increased several-fold in patients with atorvastatin-induced myopathy. Hermann, M., Bogsrud, M.P., Molden, E., Asberg, A., Mohebi, B.U., Ose, L., Retterstøl, K. Clin. Pharmacol. Ther. (2006)
- The human organic anion transporting polypeptide 8 (SLCO1B3) gene is transcriptionally repressed by hepatocyte nuclear factor 3beta in hepatocellular carcinoma. Vavricka, S.R., Jung, D., Fried, M., Grützner, U., Meier, P.J., Kullak-Ublick, G.A. J. Hepatol. (2004)
- Disposition and sterol-lowering effect of ezetimibe are influenced by single-dose coadministration of rifampin, an inhibitor of multidrug transport proteins. Oswald, S., Giessmann, T., Luetjohann, D., Wegner, D., Rosskopf, D., Weitschies, W., Siegmund, W. Clin. Pharmacol. Ther. (2006)
- Pharmacokinetics and response to pravastatin in paediatric patients with familial hypercholesterolaemia and in paediatric cardiac transplant recipients in relation to polymorphisms of the SLCO1B1 and ABCB1 genes. Hedman, M., Antikainen, M., Holmberg, C., Neuvonen, M., Eichelbaum, M., Kivistö, K.T., Neuvonen, P.J., Niemi, M. British journal of clinical pharmacology. (2006)
- Simvastatin does not influence the intestinal P-glycoprotein and MPR2, and the disposition of talinolol after chronic medication in healthy subjects genotyped for the ABCB1, ABCC2 and SLCO1B1 polymorphisms. Bernsdorf, A., Giessmann, T., Modess, C., Wegner, D., Igelbrink, S., Hecker, U., Haenisch, S., Cascorbi, I., Terhaag, B., Siegmund, W. British journal of clinical pharmacology. (2006)