Gene Review:
HEXIM1 - hexamethylene bis-acetamide inducible 1
Homo sapiens
Synonyms:
CLP-1, CLP1, Cardiac lineage protein 1, EDG1, Estrogen down-regulated gene 1 protein, ...
- Regulation of polymerase II transcription by 7SK snRNA: two distinct RNA elements direct P-TEFb and HEXIM1 binding. Egloff, S., Van Herreweghe, E., Kiss, T. Mol. Cell. Biol. (2006)
- Phosphorylated positive transcription elongation factor b (P-TEFb) is tagged for inhibition through association with 7SK snRNA. Chen, R., Yang, Z., Zhou, Q. J. Biol. Chem. (2004)
- Increased HEXIM1 expression during erythroleukemia and neuroblastoma cell differentiation. Turano, M., Napolitano, G., Dulac, C., Majello, B., Bensaude, O., Lania, L. J. Cell. Physiol. (2006)
- Identification of a novel inhibitor of breast cell growth that is down-regulated by estrogens and decreased in breast tumors. Wittmann, B.M., Wang, N., Montano, M.M. Cancer Res. (2003)
- Identification of a cyclin T-binding domain in Hexim1 and biochemical analysis of its binding competition with HIV-1 Tat. Schulte, A., Czudnochowski, N., Barboric, M., Schönichen, A., Blazek, D., Peterlin, B.M., Geyer, M. J. Biol. Chem. (2005)
- Efficient thymic immigration of B220+ lymphoid-restricted bone marrow cells with T precursor potential. Martin, C.H., Aifantis, I., Scimone, M.L., von Andrian, U.H., Reizis, B., von Boehmer, H., Gounari, F. Nat. Immunol. (2003)
- Recruitment of P-TEFb for stimulation of transcriptional elongation by the bromodomain protein Brd4. Yang, Z., Yik, J.H., Chen, R., He, N., Jang, M.K., Ozato, K., Zhou, Q. Mol. Cell (2005)
- Inhibition of P-TEFb (CDK9/Cyclin T) kinase and RNA polymerase II transcription by the coordinated actions of HEXIM1 and 7SK snRNA. Yik, J.H., Chen, R., Nishimura, R., Jennings, J.L., Link, A.J., Zhou, Q. Mol. Cell (2003)
- Interplay between 7SK snRNA and oppositely charged regions in HEXIM1 direct the inhibition of P-TEFb. Barboric, M., Kohoutek, J., Price, J.P., Blazek, D., Price, D.H., Peterlin, B.M. EMBO J. (2005)
- The novel sphingosine 1-phosphate receptor AGR16 is coupled via pertussis toxin-sensitive and -insensitive G-proteins to multiple signalling pathways. Gonda, K., Okamoto, H., Takuwa, N., Yatomi, Y., Okazaki, H., Sakurai, T., Kimura, S., Sillard, R., Harii, K., Takuwa, Y. Biochem. J. (1999)
- HEXIM1 forms a transcriptionally abortive complex with glucocorticoid receptor without involving 7SK RNA and positive transcription elongation factor b. Shimizu, N., Ouchida, R., Yoshikawa, N., Hisada, T., Watanabe, H., Okamoto, K., Kusuhara, M., Handa, H., Morimoto, C., Tanaka, H. Proc. Natl. Acad. Sci. U.S.A. (2005)
- Compensatory contributions of HEXIM1 and HEXIM2 in maintaining the balance of active and inactive positive transcription elongation factor b complexes for control of transcription. Yik, J.H., Chen, R., Pezda, A.C., Zhou, Q. J. Biol. Chem. (2005)
- HEXIM2, a HEXIM1-related protein, regulates positive transcription elongation factor b through association with 7SK. Byers, S.A., Price, J.P., Cooper, J.J., Li, Q., Price, D.H. J. Biol. Chem. (2005)
- siRNA depletion of 7SK snRNA induces apoptosis but does not affect expression of the HIV-1 LTR or P-TEFb-dependent cellular genes. Haaland, R.E., Herrmann, C.H., Rice, A.P. J. Cell. Physiol. (2005)
- Effects of prostratin on Cyclin T1/P-TEFb function and the gene expression profile in primary resting CD4+ T cells. Sung, T.L., Rice, A.P. Retrovirology (2006)
- Suppression of NF-kappaB-dependent gene expression by a hexamethylene bisacetamide-inducible protein HEXIM1 in human vascular smooth muscle cells. Ouchida, R., Kusuhara, M., Shimizu, N., Hisada, T., Makino, Y., Morimoto, C., Handa, H., Ohsuzu, F., Tanaka, H. Genes Cells (2003)
- Transcription-dependent association of multiple positive transcription elongation factor units to a HEXIM multimer. Dulac, C., Michels, A.A., Fraldi, A., Bonnet, F., Nguyen, V.T., Napolitano, G., Lania, L., Bensaude, O. J. Biol. Chem. (2005)
- Analysis of the large inactive P-TEFb complex indicates that it contains one 7SK molecule, a dimer of HEXIM1 or HEXIM2, and two P-TEFb molecules containing Cdk9 phosphorylated at threonine 186. Li, Q., Price, J.P., Byers, S.A., Cheng, D., Peng, J., Price, D.H. J. Biol. Chem. (2005)
- Ligand-induced trafficking of the sphingosine-1-phosphate receptor EDG-1. Liu, C.H., Thangada, S., Lee, M.J., Van Brocklyn, J.R., Spiegel, S., Hla, T. Mol. Biol. Cell (1999)
- MAQ1 and 7SK RNA interact with CDK9/cyclin T complexes in a transcription-dependent manner. Michels, A.A., Nguyen, V.T., Fraldi, A., Labas, V., Edwards, M., Bonnet, F., Lania, L., Bensaude, O. Mol. Cell. Biol. (2003)
- Hexim1 sequesters positive transcription elongation factor b from the class II transactivator on MHC class II promoters. Kohoutek, J., Blazek, D., Peterlin, B.M. Proc. Natl. Acad. Sci. U.S.A. (2006)
- Binding of the 7SK snRNA turns the HEXIM1 protein into a P-TEFb (CDK9/cyclin T) inhibitor. Michels, A.A., Fraldi, A., Li, Q., Adamson, T.E., Bonnet, F., Nguyen, V.T., Sedore, S.C., Price, J.P., Price, D.H., Lania, L., Bensaude, O. EMBO J. (2004)
- Structure, expression, and functional characterization of the mouse CLP-1 gene. Huang, F., Wagner, M., Siddiqui, M.A. Gene (2002)