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FUT9  -  fucosyltransferase 9 (alpha (1,3)...

Homo sapiens

Synonyms: Alpha-(1,3)-fucosyltransferase 9, Fuc-TIX, FucT-IX, Fucosyltransferase 9, Fucosyltransferase IX, ...
 
 
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High impact information on FUT9

 

Biological context of FUT9

  • FUT4 and FUT9 genes are expressed early in human embryogenesis [2].
  • Like FUT4, this embryonic FUT9 is N-ethylmaleimide and heat resistant and the corresponding gene was confirmed to be localized in the chromosome band 6q16 [2].
  • Using mRNA from 40- to 65-day-old embryos, we have prepared different hexamer and oligo-dT cDNA libraries and cloned, by rapid amplification cDNA ends-PCR, FUT4 and FUT9 alpha3-fucosyltransferase transcripts [2].
  • The acceptor specificity and the kinetics of the alpha3-fucosyltransferase encoded by this FUT9 transcript are similar to the FUT4 enzyme, except for the utilization of the lac-di-NAc acceptor which is not efficiently transformed by the FUT9 enzyme [2].
 

Anatomical context of FUT9

  • From RT-PCR studies, enzyme specificity of cellular extracts towards a panel of synthetic carbohydrate acceptors and Western blot analysis we concluded that Lea, sLea and Leb were synthesised by FUT3, whereas Lex and Ley were synthesized by FUT4 and FUT9 in both cell lines [3].
 

Associations of FUT9 with chemical compounds

 

Other interactions of FUT9

  • This indicated that FUT9 exhibits more efficient activity for the synthesis of Lewis x carbohydrate epitope (Le(x); CD15; stage-specific embryonal antigen-1 (SSEA-1)) [4].
  • After the emergence of tetrapods, the mutation rate of FUT9 decreased dramatically, suggesting the early acquisition of a crucial fucosyltransferase activity in the first stages of development [5].
 

Analytical, diagnostic and therapeutic context of FUT9

References

  1. CD15 expression in mature granulocytes is determined by alpha 1,3-fucosyltransferase IX, but in promyelocytes and monocytes by alpha 1,3-fucosyltransferase IV. Nakayama, F., Nishihara, S., Iwasaki, H., Kudo, T., Okubo, R., Kaneko, M., Nakamura, M., Karube, M., Sasaki, K., Narimatsu, H. J. Biol. Chem. (2001) [Pubmed]
  2. FUT4 and FUT9 genes are expressed early in human embryogenesis. Cailleau-Thomas, A., Coullin, P., Candelier, J.J., Balanzino, L., Mennesson, B., Oriol, R., Mollicone, R. Glycobiology (2000) [Pubmed]
  3. Different expression levels of alpha3/4 fucosyltransferases and Lewis determinants in ovarian carcinoma tissues and cell lines. Escrevente, C., Machado, E., Brito, C., Reis, C.A., Stoeck, A., Runz, S., Marmé, A., Altevogt, P., Costa, J. Int. J. Oncol. (2006) [Pubmed]
  4. Alpha1,3-fucosyltransferase 9 (FUT9; Fuc-TIX) preferentially fucosylates the distal GlcNAc residue of polylactosamine chain while the other four alpha1,3FUT members preferentially fucosylate the inner GlcNAc residue. Nishihara, S., Iwasaki, H., Kaneko, M., Tawada, A., Ito, M., Narimatsu, H. FEBS Lett. (1999) [Pubmed]
  5. En Bloc Duplications, Mutation Rates, and Densities of Amino Acid Changes Clarify the Evolution of Vertebrate alpha-1,3/4-Fucosyltransferases. Petit, D., Maftah, A., Julien, R., Petit, J.M. J. Mol. Evol. (2006) [Pubmed]
  6. Assignment of the human alpha 1,3-fucosyltransferase IX gene (FUT9) to chromosome band 6q16 by in situ hybridization. Kaneko, M., Kudo, T., Iwasaki, H., Shiina, T., Inoko, H., Kozaki, T., Saitou, N., Narimatsu, H. Cytogenet. Cell Genet. (1999) [Pubmed]
 
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