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Gene Review

MRPS30  -  mitochondrial ribosomal protein S30

Homo sapiens

Synonyms: 28S ribosomal protein S30, mitochondrial, BM-047, MRP-S30, PAP, PDCD9, ...
 
 
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Disease relevance of MRPS30

 

Psychiatry related information on MRPS30

  • The measurement of transmural values allowed a reliable assessment of PAP changes occurring during apneas, and different degrees of such changes shown by different patients may be related to a host of factors relevant to wakefulness and sleep, including individual responsivity to hypoxic stimulus [5].
  • This review presents the possible involvement of 3'(2')-phosphoadenosine-5'-phosphate (PAP) phosphatase in the etiology of bipolar disorder and the mechanism of action of Li [6].
  • Physiological data (VO2peak, height, and weight), psychological data (physical self-perception profile subscale scores), information about physical activity participation (PAP, d x wk(-1)) and qualitative impressions (QI) of the program were collected pre- and post-intervention [7].
 

High impact information on MRPS30

  • Monospecific rabbit antiserums to PAPP-A, PAPP-C and hCS all stained the trophoblast cytoplasm equivalently in a continuous layer, usggesting that the same trophoblast cells synthesize all three pregnancy proteins [8].
  • Enhanced expression of PAP upon VIIa binding to tumor cell TF may potentially play an important role in tumor metastasis [4].
  • We also measured activation of thrombin: thrombin-antithrombin III (TAT), prothrombin fragment 1 + 2 (F1 + 2), and fibrinopeptide A (FPA) as well as markers of fibrinolysis: plasmin-alpha 2-antiplasmin (PAP) and D-dimer [9].
  • We measured pulmonary arterial (PAP) and occlusive wedge pressures and cardiac output at rest (i.e., standing) and during progressive upright treadmill exercise in 51 patients [10].
  • Forty-two had chronic, stable, cardiac failure secondary to ischemic, myopathic or valvular heart disease and were grouped according to whether their mean PAP was less than (normotensive) or greater than (hypertensive) 19 mm Hg, and nine had pulmonary vascular disease of diverse etiology and were considered separately [10].
 

Chemical compound and disease context of MRPS30

  • We used this SCID mouse model of human pre-B ALL to evaluate and compare, in a total of 434 SCID mice, the antileukemic efficacy of B43 (anti-CD19)-pokeweed antiviral protein (PAP) immunotoxin and cyclophosphamide (CPA) as individual reagents and as combined immunochemotherapeutic regimens [11].
  • HIP/PAP transgenic mice were protected against acetaminophen-induced acute liver failure and were stimulated to regenerate post-hepatectomy [12].
  • While neither low nor high doses of DHAS and PAP exerted any significant influence on the incidence of ductal lesions including carcinomas, the high dose of DHAS (350 mg/kg body wt) and a both low (90 mg/kg) and high (180 mg/kg) doses of PAP reduced the mean numbers of pancreatic ductal adenocarcinomas [13].
  • Using the PAP method, localization of the calcineurin in formalin-fixed, paraffin-embedded tissues were studied in 65 human intracranial neoplasms, and in 11 human extracranial neoplasms [14].
  • In 3 patients with acute myeloblastic leukemia, APL and pancreatic cancer, respectively, the PAP level remained high during heparin therapy although the TAT level was decreased [15].
 

Biological context of MRPS30

 

Anatomical context of MRPS30

  • PDCD9 mRNA is expressed ubiquitously in adult tissues, displaying a stronger signal in heart, skeletal muscle, kidney, and liver [16].
  • Mucosal PAP smears show lack of epithelial maturation, cytoplasmic vacuoles and inclusions, and individual cell dyskeratosis [20].
  • Deficiency of granulocyte-macrophage colony-stimulating factor (GM-CSF) in mice results in pulmonary alveolar proteinosis (PAP) from impaired surfactant catabolism by alveolar macrophages (AMs) [21].
  • In contrast, correlations were noted between PS-positive erythrocytes and F1.2 (P <.0002), D-dimer (P <.000002), and PAP (P <.01) [22].
  • B43-PAP immunotoxin (1) showed strong and antigen-specific reactivity with BCL-1 cells, (2) promptly penetrated the spleens of leukemic mice, (3) rapidly reduced the BCL-1 leukemia burden of leukemic mice and, most importantly, (4) improved survival [18].
 

Associations of MRPS30 with chemical compounds

 

Other interactions of MRPS30

 

Analytical, diagnostic and therapeutic context of MRPS30

  • Frozen sections of human placenta were examined for the presence of four human pregnancy proteins, pregnancy-associated plasma proteins A and C (PAPP-A and PAPP-C), human chorionic somatomammotropin (hCS), and pregnancy zone protein (PZP), by the indirect immunofluorescence technique [8].
  • The complex formation was demonstrated by the binding of fluid-phase IgG from normal adults and the same TTP patient after recovery to adsorbed PAP by using an enzyme-linked immunosorbent assay [27].
  • Further, antibody-PAP conjugate was separated from PAP by differential precipitation using polyethyleneglycol, and the PAP content of the fractions were analyzed by radioimmunoassay [28].
  • In order to gain insight into the possible role of HIP/PAP in vivo, we have investigated the pattern of HIP/PAP expression in the developing postimplantation mouse embryo by in situ hybridization [29].
  • Using a PAP immunoperoxidase technique, we have demonstrated the plasma protein prealbumin in 92 (87 per cent) out of a series of 106 carcinoid tumours from various sites [30].

References

  1. Mutations in MKKS cause Bardet-Biedl syndrome. Slavotinek, A.M., Stone, E.M., Mykytyn, K., Heckenlively, J.R., Green, J.S., Heon, E., Musarella, M.A., Parfrey, P.S., Sheffield, V.C., Biesecker, L.G. Nat. Genet. (2000) [Pubmed]
  2. Idiopathic pulmonary alveolar proteinosis as an autoimmune disease with neutralizing antibody against granulocyte/macrophage colony-stimulating factor. Kitamura, T., Tanaka, N., Watanabe, J., Uchida, n.u.l.l., Kanegasaki, S., Yamada, Y., Nakata, K. J. Exp. Med. (1999) [Pubmed]
  3. Human pulmonary alveolar proteinosis associated with a defect in GM-CSF/IL-3/IL-5 receptor common beta chain expression. Dirksen, U., Nishinakamura, R., Groneck, P., Hattenhorst, U., Nogee, L., Murray, R., Burdach, S. J. Clin. Invest. (1997) [Pubmed]
  4. Binding of factor VIIa to tissue factor induces alterations in gene expression in human fibroblast cells: up-regulation of poly(A) polymerase. Pendurthi, U.R., Alok, D., Rao, L.V. Proc. Natl. Acad. Sci. U.S.A. (1997) [Pubmed]
  5. Transmural pressure measurements. Importance in the assessment of pulmonary hypertension in obstructive sleep apneas. Marrone, O., Bellia, V., Ferrara, G., Milone, F., Romano, L., Salvaggio, A., Stallone, A., Bonsignore, G. Chest (1989) [Pubmed]
  6. Possible role of 3'(2')-phosphoadenosine-5'-phosphate phosphatase in the etiology and therapy of bipolar disorder. Agam, G., Shaltiel, G. Prog. Neuropsychopharmacol. Biol. Psychiatry (2003) [Pubmed]
  7. Daughters and mothers exercising together (DAMET): a 12-week pilot project designed to improve physical self-perception and increase recreational physical activity. Ransdell, L.B., Dratt, J., Kennedy, C., O'Neill, S., DeVoe, D. Women & health. (2001) [Pubmed]
  8. Placental localization of human pregnancy--associated plasma proteins. Lin, T.M., Halbert, S.P. Science (1976) [Pubmed]
  9. Increased activation of the coagulation and fibrinolytic systems leads to hemorrhagic complications during left ventricular assist implantation. Livingston, E.R., Fisher, C.A., Bibidakis, E.J., Pathak, A.S., Todd, B.A., Furukawa, S., McClurken, J.B., Addonizio, V.P., Jeevanandam, V. Circulation (1996) [Pubmed]
  10. The pressure-flow response of the pulmonary circulation in patients with heart failure and pulmonary vascular disease. Janicki, J.S., Weber, K.T., Likoff, M.J., Fishman, A.P. Circulation (1985) [Pubmed]
  11. Effective immunochemotherapy of CALLA+C mu+ human pre-B acute lymphoblastic leukemia in mice with severe combined immunodeficiency using B43 (anti-CD19) pokeweed antiviral protein immunotoxin plus cyclophosphamide. Uckun, F.M., Chelstrom, L.M., Finnegan, D., Tuel-Ahlgren, L., Manivel, C., Irvin, J.D., Myers, D.E., Gunther, R. Blood (1992) [Pubmed]
  12. Reg2 inactivation increases sensitivity to Fas hepatotoxicity and delays liver regeneration post-hepatectomy in mice. Lieu, H.T., Simon, M.T., Nguyen-Khoa, T., Kebede, M., Cortes, A., Tebar, L., Smith, A.J., Bayne, R., Hunt, S.P., Br??chot, C., Christa, L. Hepatology (2006) [Pubmed]
  13. Inhibitory effects of sulfation inhibitors on initiation of pancreatic ductal carcinogenesis by N-nitrosobis(2-oxopropyl)amine in hamsters. Tsutsumi, M., Noguchi, O., Okita, S., Horiguchi, K., Kobayashi, E., Tamura, K., Tsujiuchi, T., Denda, A., Konishi, Y., Iimura, K. Carcinogenesis (1995) [Pubmed]
  14. Calcineurin as a neuronal marker of human brain tumors. Goto, S., Matsukado, Y., Mihara, Y., Inoue, N., Miyamoto, E. Brain Res. (1986) [Pubmed]
  15. Imbalance between thrombin and plasmin activity in disseminated intravascular coagulation. Assessment by the thrombin-antithrombin-III complex/plasmin-alpha-2-antiplasmin complex ratio. Kario, K., Matsuo, T., Kodama, K., Matsuo, M., Yamamoto, K., Kobayashi, H. Haemostasis (1992) [Pubmed]
  16. Cloning, expression, and mapping of PDCD9, the human homolog of Gallus gallus pro-apoptotic protein p52. Carim, L., Sumoy, L., Nadal, M., Estivill, X., Escarceller, M. Cytogenet. Cell Genet. (1999) [Pubmed]
  17. Polynucleotide phosphorylase functions as both an exonuclease and a poly(A) polymerase in spinach chloroplasts. Yehudai-Resheff, S., Hirsh, M., Schuster, G. Mol. Cell. Biol. (2001) [Pubmed]
  18. In vivo efficacy of B43 (anti-CD19)-pokeweed antiviral protein immunotoxin against BCL-1 murine B-cell leukemia. Uckun, F.M., Chelstrom, L.M., Irvin, J.D., Finnegan, D., Gunther, R., Young, J., Kuebelbeck, V., Myers, D.E., Houston, L.L. Blood (1992) [Pubmed]
  19. Defective expression of granulocyte-macrophage colony-stimulating factor/interleukin-3/interleukin-5 receptor common beta chain in children with acute myeloid leukemia associated with respiratory failure. Dirksen, U., Hattenhorst, U., Schneider, P., Schroten, H., Göbel, U., Böcking, A., Müller, K.M., Murray, R., Burdach, S. Blood (1998) [Pubmed]
  20. Hereditary mucoepithelial dysplasia: a disease apparently of desmosome and gap junction formation. Witkop, C.J., White, J.G., King, R.A., Dahl, M.V., Young, W.G., Sauk, J.J. Am. J. Hum. Genet. (1979) [Pubmed]
  21. High-affinity autoantibodies specifically eliminate granulocyte-macrophage colony-stimulating factor activity in the lungs of patients with idiopathic pulmonary alveolar proteinosis. Uchida, K., Nakata, K., Trapnell, B.C., Terakawa, T., Hamano, E., Mikami, A., Matsushita, I., Seymour, J.F., Oh-Eda, M., Ishige, I., Eishi, Y., Kitamura, T., Yamada, Y., Hanaoka, K., Keicho, N. Blood (2004) [Pubmed]
  22. Thrombophilia in sickle cell disease: the red cell connection. Setty, B.N., Rao, A.K., Stuart, M.J. Blood (2001) [Pubmed]
  23. Crystal structure of the human estrogen sulfotransferase-PAPS complex: evidence for catalytic role of Ser137 in the sulfuryl transfer reaction. Pedersen, L.C., Petrotchenko, E., Shevtsov, S., Negishi, M. J. Biol. Chem. (2002) [Pubmed]
  24. A novel mammalian lithium-sensitive enzyme with a dual enzymatic activity, 3'-phosphoadenosine 5'-phosphate phosphatase and inositol-polyphosphate 1-phosphatase. López-Coronado, J.M., Bellés, J.M., Lesage, F., Serrano, R., Rodríguez, P.L. J. Biol. Chem. (1999) [Pubmed]
  25. Cell surface detachment of pregnancy-associated plasma protein-A requires the formation of intermolecular proteinase-inhibitor disulfide bonds and glycosaminoglycan covalently bound to the inhibitor. Glerup, S., Kløverpris, S., Laursen, L.S., Dagnaes-Hansen, F., Thiel, S., Conover, C.A., Oxvig, C. J. Biol. Chem. (2007) [Pubmed]
  26. A new face on apoptosis: death-associated protein 3 and PDCD9 are mitochondrial ribosomal proteins. Cavdar Koc, E., Ranasinghe, A., Burkhart, W., Blackburn, K., Koc, H., Moseley, A., Spremulli, L.L. FEBS Lett. (2001) [Pubmed]
  27. Platelet-agglutinating protein P37 from a thrombotic thrombocytopenic purpura plasma forms a complex with human immunoglobulin G. Siddiqui, F.A., Lian, E.C. Blood (1988) [Pubmed]
  28. Immunological and biological stability of immunotoxins in vivo as studied by the clearance of disulfide-linked pokeweed antiviral protein-antibody conjugates from blood. Ramakrishnan, S., Houston, L.L. Cancer Res. (1985) [Pubmed]
  29. HIP/PAP gene, encoding a C-type lectin overexpressed in primary liver cancer, is expressed in nervous system as well as in intestine and pancreas of the postimplantation mouse embryo. Lasserre, C., Colnot, C., Bréchot, C., Poirier, F. Am. J. Pathol. (1999) [Pubmed]
  30. Immunolocalization of prealbumin as a marker for carcinoid tumours. Miller, I.D., Reid, W.A., Liddle, C.N., Horne, C.H. J. Pathol. (1984) [Pubmed]
 
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