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Gene Review

Emo1  -  emotionality 1

Mus musculus

 
 
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Disease relevance of Emo1

  • Emotionality and shelf level predicted IDDM in females only [1].
  • The difference was independent of emotionality (as measured by defaecation) and general body health (as measured by body weight and a subjectively assessed health rating) [2].
  • Thus, prenatal brief hyperthermia in mice was shown to suppress the body and brain growth during the postnatal period and adversely affect their emotionality and learning capacity [3].
  • The response to high levels of shock may also be an indication of enhanced emotionality, an interpretation consistent with reports in other lupus-prone strains and affective disorders in humans with lupus [4].
 

Psychiatry related information on Emo1

  • In tests of spontaneous social behavior (allogrooming, anogenital licking, mounting, fighting), as well as in tests for emotionality (open field: crossed fields and defecation), these behavioral patterns occurred less frequently in MZT than in DZT; the NBA were mostly intermediate [5].
  • Moreover, these animals show a decreased locomotor activity and an increased level of emotionality/anxiety in three standard behavioral tests (the holeboard, the open field and the plus-maze) when compared to fast mice [6].
  • As housing represents a fundamental external factor, which is controversially debated to affect the animals' emotionality, this study aimed to investigate the impact of different social and structural housing conditions on the development of a depressive-like syndrome in the learned helplessness paradigm [7].
  • A number of loci mapped in this study share overlapping candidate regions with previously identified emotionality QTL in mice as well as with susceptibility loci recognized by linkage or genome scan analyses for major depression or bipolar disorder in humans [8].
  • The basal behavioral profile of the HZ genotype reveals important differences, consistent with decreased behavioral inhibition and emotionality, which can be revealed as early as in adolescence, together with slight increment of impulsive behavior and altered pain threshold and at the adult age [9].
 

High impact information on Emo1

 

Chemical compound and disease context of Emo1

  • Cognitive behaviour, emotionality, and locomotor activity were also determined at 10 and 18 months of age in treated since weaning and untreated control rats to elucidate the participation of angiotensin II in memory disfunction [14].
 

Biological context of Emo1

 

Anatomical context of Emo1

 

Associations of Emo1 with chemical compounds

 

Regulatory relationships of Emo1

  • Therefore, IL-6(-/-) mice seem to be more emotional than their appropriate controls, suggesting that the major cytokine IL-6 is involved in the control of emotionality [29].
 

Other interactions of Emo1

  • Considerable evidence suggests that arginine vasopressin (AVP) is critically involved in the regulation of many social and nonsocial behaviors, including emotionality [30].
  • Neuropeptide Y (NPY) is involved in the regulation of emotionality including fear and anxiety, which modulate autonomic control of cardiovascular function [31].
  • However, consistent with the notion that central CRH alterations induced by SEB may affect emotionality (e.g., fear), SEB challenge augmented appetitive neophobia in a context-dependent manner, being marked in a novel and stressful environment [32].
  • IL-6 deficiency leads to increased emotionality in mice: evidence in transgenic mice carrying a null mutation for IL-6 [29].
  • In contrast, the general level of emotionality of both IFNgamma (+/+) and (-/-) BALB/c (C) mice was substantially greater than that of either of the B6 mouse groups [33].
 

Analytical, diagnostic and therapeutic context of Emo1

References

  1. Group size, cage shelf level, and emotionality in non-obese diabetic mice: impact on onset and incidence of IDDM. Ader, D.N., Johnson, S.B., Huang, S.W., Riley, W.J. Psychosomatic medicine. (1991) [Pubmed]
  2. The effect of congenital and adult-acquired Toxoplasma infections on the motor performance of mice. Hay, J., Aitken, P.P., Hutchison, W.M., Graham, D.I. Ann. Trop. Med. Parasitol. (1983) [Pubmed]
  3. Effects of prenatal heat stress on postnatal growth, behavior and learning capacity in mice. Shiota, K., Kayamura, T. Biol. Neonate (1989) [Pubmed]
  4. Sensitivity to foot shock in autoimmune NZB x NZW F1 hybrid mice. Schrott, L.M., Crnic, L.S. Physiol. Behav. (1994) [Pubmed]
  5. Monozygotic vs. dizygotic twin behavior in artificial mouse twins. Baunack, E., Falk, U., Gärtner, K. Genetics (1984) [Pubmed]
  6. Behavioral characterization of a mouse model of premature immunosenescence. Viveros, M.P., Fernández, B., Guayerbas, N., De la Fuente, M. J. Neuroimmunol. (2001) [Pubmed]
  7. Social and structural housing conditions influence the development of a depressive-like phenotype in the learned helplessness paradigm in male mice. Chourbaji, S., Zacher, C., Sanchis-Segura, C., Spanagel, R., Gass, P. Behav. Brain Res. (2005) [Pubmed]
  8. Sex- and lineage-specific inheritance of depression-like behavior in the rat. Solberg, L.C., Baum, A.E., Ahmadiyeh, N., Shimomura, K., Li, R., Turek, F.W., Churchill, G.A., Takahashi, J.S., Redei, E.E. Mamm. Genome (2004) [Pubmed]
  9. Impulsivity-anxiety-related behavior and profiles of morphine-induced analgesia in heterozygous reeler mice. Ognibene, E., Adriani, W., Granstrem, O., Pieretti, S., Laviola, G. Brain Res. (2007) [Pubmed]
  10. A simple genetic basis for a complex psychological trait in laboratory mice. Flint, J., Corley, R., DeFries, J.C., Fulker, D.W., Gray, J.A., Miller, S., Collins, A.C. Science (1995) [Pubmed]
  11. The V1a vasopressin receptor is necessary and sufficient for normal social recognition: a gene replacement study. Bielsky, I.F., Hu, S.B., Ren, X., Terwilliger, E.F., Young, L.J. Neuron (2005) [Pubmed]
  12. Parkin-deficient mice are not a robust model of parkinsonism. Perez, F.A., Palmiter, R.D. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  13. Glucocorticoid receptor overexpression in forebrain: a mouse model of increased emotional lability. Wei, Q., Lu, X.Y., Liu, L., Schafer, G., Shieh, K.R., Burke, S., Robinson, T.E., Watson, S.J., Seasholtz, A.F., Akil, H. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
  14. Protective effect of the inhibition of the renin-angiotensin system on aging. Basso, N., Paglia, N., Stella, I., de Cavanagh, E.M., Ferder, L., del Rosario Lores Arnaiz, M., Inserra, F. Regul. Pept. (2005) [Pubmed]
  15. High-resolution mapping of quantitative trait loci for emotionality in selected strains of mice. Turri, M.G., Talbot, C.J., Radcliffe, R.A., Wehner, J.M., Flint, J. Mamm. Genome (1999) [Pubmed]
  16. Multivariate neurocognitive and emotional profile of a mannosidosis murine model for therapy assessment. Caeyenberghs, K., Balschun, D., Roces, D.P., Schwake, M., Saftig, P., D'Hooge, R. Neurobiol. Dis. (2006) [Pubmed]
  17. Examination of behavioral deficits triggered by targeting BDNF in fetal or postnatal brains of mice. Chan, J.P., Unger, T.J., Byrnes, J., Rios, M. Neuroscience (2006) [Pubmed]
  18. Mice with astrocyte-directed inactivation of connexin43 exhibit increased exploratory behaviour, impaired motor capacities, and changes in brain acetylcholine levels. Frisch, C., Theis, M., De Souza Silva, M.A., Dere, E., Söhl, G., Teubner, B., Namestkova, K., Willecke, K., Huston, J.P. Eur. J. Neurosci. (2003) [Pubmed]
  19. Exploration, emotionality, and hippocampal mossy fibers in nonaggressive AB/Gat and congenic highly aggressive mice. Prior, H., Schwegler, H., Marashi, V., Sachser, N. Hippocampus. (2004) [Pubmed]
  20. Do animal models have a place in the genetic analysis of quantitative human behavioural traits? Flint, J., Corley, R. J. Mol. Med. (1996) [Pubmed]
  21. Long-term effects of postovulatory aging of mouse oocytes on offspring: a two-generational study. Tarín, J.J., Pérez-Albalá, S., Aguilar, A., Miñarro, J., Hermenegildo, C., Cano, A. Biol. Reprod. (1999) [Pubmed]
  22. Relation of behaviour and macrophage function to life span in a murine model of premature immunosenescence. Guayerbas, N., Catalán, M., Víctor, V.M., Miquel, J., De la Fuente, M. Behav. Brain Res. (2002) [Pubmed]
  23. Maternal influences on adult stress and anxiety-like behavior in C57BL/6J and BALB/CJ mice: A cross-fostering study. Priebe, K., Brake, W.G., Romeo, R.D., Sisti, H.M., Mueller, A., McEwen, B.S., Francis, D.D. Developmental psychobiology. (2006) [Pubmed]
  24. Changes in motoric, exploratory and emotional behaviours and neuronal acetylcholine content and 5-HT turnover in histidine decarboxylase-KO mice. Dere, E., De Souza-Silva, M.A., Spieler, R.E., Lin, J.S., Ohtsu, H., Haas, H.L., Huston, J.P. Eur. J. Neurosci. (2004) [Pubmed]
  25. Abolition of sex-dependent effects of prenatal exposure to diethylstilbestrol on emotional behavior in estrogen receptor-alpha knockout mice. Tomihara, K., Kaitsuka, T., Soga, T., Korach, K.S., Pfaff, D.W., Takahama, K., Ogawa, S. Neuroreport (2006) [Pubmed]
  26. Effects of sedatives on GABA-mediated chloride flux into cerebral cortical microsacs prepared from emotional and non-emotional mice. Mihic, S.J., Van Berckel, B.N., O'Dowd, B.F., Nguyen, T., Wu, P.H. Eur. J. Pharmacol. (1992) [Pubmed]
  27. Activity, non-selective attention and emotionality in dopamine D2/D3 receptor knock-out mice. Vallone, D., Pignatelli, M., Grammatikopoulos, G., Ruocco, L., Bozzi, Y., Westphal, H., Borrelli, E., Sadile, A.G. Behav. Brain Res. (2002) [Pubmed]
  28. Effect of ethanol on memory consolidation in mice: antagonism by the imidazobenzodiazepine Ro 15-4513 and decrement by familiarization with the environment. Castellano, C., Populin, R. Behav. Brain Res. (1990) [Pubmed]
  29. IL-6 deficiency leads to increased emotionality in mice: evidence in transgenic mice carrying a null mutation for IL-6. Armario, A., Hernández, J., Bluethmann, H., Hidalgo, J. J. Neuroimmunol. (1998) [Pubmed]
  30. Profound impairment in social recognition and reduction in anxiety-like behavior in vasopressin V1a receptor knockout mice. Bielsky, I.F., Hu, S.B., Szegda, K.L., Westphal, H., Young, L.J. Neuropsychopharmacology (2004) [Pubmed]
  31. Central NPY receptor-mediated alteration of heart rate dynamics in mice during expression of fear conditioned to an auditory cue. Tovote, P., Meyer, M., Beck-Sickinger, A.G., von Hörsten, S., Ove Ogren, S., Spiess, J., Stiedl, O. Regul. Pept. (2004) [Pubmed]
  32. T-lymphocyte activation increases hypothalamic and amygdaloid expression of CRH mRNA and emotional reactivity to novelty. Kusnecov, A.W., Liang, R., Shurin, G. J. Neurosci. (1999) [Pubmed]
  33. The influence of a targeted deletion of the IFNgamma gene on emotional behaviors. Kustova, Y., Sei, Y., Morse, H.C., Basile, A.S. Brain Behav. Immun. (1998) [Pubmed]
  34. Differences in the liability to self-administer intravenous cocaine between C57BL/6 x SJL and BALB/cByJ mice. Deroche, V., Caine, S.B., Heyser, C.J., Polis, I., Koob, G.F., Gold, L.H. Pharmacol. Biochem. Behav. (1997) [Pubmed]
 
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