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Gene Review

SERINC3  -  serine incorporator 3

Homo sapiens

Synonyms: AIGP1, DIFF33, SBBI99, Serine incorporator 3, TDE, ...
 
 
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Disease relevance of SERINC3

  • ASC/TMS1 protein levels are reduced in all lung cancer types (30 of 40; 75%) but not in 10 preinvasive lesions [1].
  • In this study, we examined methylation and expression of TMS1/ASC in glioblastoma multiforme (GBM) [2].
  • Previous studies have shown that TMS1/ASC is silenced by epigenetic means in human breast tumors [2].
  • METHODS.: A retrospective analysis was performed on 21 eyes of 14 previously diagnosed keratoconus patients from a single practice using a Tomey TMS-1, an Alcon EyeMap, and a Keratron Topographer [3].
  • CONCLUSION: Our study demonstrates that methylation-mediated silencing of TMS1/ASC is a frequent event in prostate cancer, thus identifying a new potential diagnostic and prognostic marker for the treatment of the disease [4].
 

High impact information on SERINC3

  • We studied this for the proapoptotic gene ASC/TMS1 in lung cancer and used the findings to develop a sputum marker [1].
  • Hypermethylation of ASC/TMS1 is a sputum marker for late-stage lung cancer [1].
  • The incidence of ASC/TMS1 hypermethylation in sputum DNA fully mimics the tissue findings being present in only 2% (2 of 85) of high-risk, cancer-free smokers, 15% (3 of 18) of patients with stage I non-small-cell lung cancer (NSCLC), but 41% of patients with stage III NSCLC (18 of 44), including 56% (10 of 18) of those with adenocarcinoma [1].
  • Each mutant contained cysteine 768 and an introduced cysteine in TMS 1 or 2 [5].
  • TMS1/ASC is an intracellular signaling molecule with proposed roles in the regulation of apoptosis, nuclear factor-kappaB activation, and cytokine maturation [2].
 

Biological context of SERINC3

  • Using fluoresence in situ hybridization analysis, we localized the human TDE gene to the q13.1-13.3 region of chromosome 20, a region known to be amplified in several types of human cancers [6].
  • To determine whether the TDE gene has a role in the development of human cancers, we used the mouse TDE cDNA sequence to screen a human placental cDNA library [6].
  • The human TDE cDNA homologue coded for a protein that was 78% homologous to the mouse TDE amino acid sequence [6].
  • Expression of hTDE1 in Rat-1 transfectants had a significant effect on cell contact inhibition in vitro as judged by a focus formation assay [7].
  • TDE2, a gene with sequence similarity to the mouse testicular tumor-differentially-expressed (Tde1/MUSTETU) gene, was identified by serial analysis of gene expression (SAGE) in nonsmall cell lung cancers (NSCLC) [8].
 

Anatomical context of SERINC3

  • The human TDE gene was expressed in all cell lines and tissues examined [6].
  • The human TDE gene homologue: localization to 20q13.1-13.3 and variable expression in human tumor cell lines and tissue [6].
  • To define whether hTDE1 may directly impact on neoplastic transformation, we derived and characterized stable Rat-1 transfectants that constitutively express hTDE1 at the plasma membrane [7].
 

Associations of SERINC3 with chemical compounds

  • The first transmembrane segment (TMS1) of UapA contains determinants necessary for expression in the plasma membrane and purine transport [9].
  • TMS1 (Target of Methylation induced Silencing), also known as ASC (Apoptosis Speck like protein containing a CARD) is a tumor suppressor gene which encodes for a CARD (caspase recruitment domain) containing regulatory protein and has been shown to promote apoptosis directly and by activation of downstream caspases [4].
 

Analytical, diagnostic and therapeutic context of SERINC3

References

  1. Hypermethylation of ASC/TMS1 is a sputum marker for late-stage lung cancer. Machida, E.O., Brock, M.V., Hooker, C.M., Nakayama, J., Ishida, A., Amano, J., Picchi, M.A., Belinsky, S.A., Herman, J.G., Taniguchi, S., Baylin, S.B. Cancer Res. (2006) [Pubmed]
  2. Aberrant methylation and down-regulation of TMS1/ASC in human glioblastoma. Stone, A.R., Bobo, W., Brat, D.J., Devi, N.S., Van Meir, E.G., Vertino, P.M. Am. J. Pathol. (2004) [Pubmed]
  3. Simulation of machine-specific topographic indices for use across platforms. Mahmoud, A.M., Roberts, C., Lembach, R., Herderick, E.E., McMahon, T.T. Optometry and vision science : official publication of the American Academy of Optometry. (2006) [Pubmed]
  4. Methylation mediated silencing of TMS1/ASC gene in prostate cancer. Das, P.M., Ramachandran, K., Vanwert, J., Ferdinand, L., Gopisetty, G., Reis, I.M., Singal, R. Mol. Cancer (2006) [Pubmed]
  5. Helix packing of the cardiac Na+-Ca2+ exchanger: proximity of transmembrane segments 1, 2, and 6. Ren, X., Nicoll, D.A., Philipson, K.D. J. Biol. Chem. (2006) [Pubmed]
  6. The human TDE gene homologue: localization to 20q13.1-13.3 and variable expression in human tumor cell lines and tissue. Bossolasco, M., Lebel, M., Lemieux, N., Mes-Masson, A.M. Mol. Carcinog. (1999) [Pubmed]
  7. Human TDE1, a TDE1/TMS family member, inhibits apoptosis in vitro and stimulates in vivo tumorigenesis. Bossolasco, M., Veillette, F., Bertrand, R., Mes-Masson, A.M. Oncogene (2006) [Pubmed]
  8. Identification of TDE2 gene and its expression in non-small cell lung cancer. Player, A., Gillespie, J., Fujii, T., Fukuoka, J., Dracheva, T., Meerzaman, D., Hong, K.M., Curran, J., Attoh, G., Travis, W., Jen, J. Int. J. Cancer (2003) [Pubmed]
  9. The first transmembrane segment (TMS1) of UapA contains determinants necessary for expression in the plasma membrane and purine transport. Pantazopoulou, A., Diallinas, G. Mol. Membr. Biol. (2006) [Pubmed]
  10. The relationship between anterior corneal aberrations and contrast sensitivity in conventional LASIK. Wang, I.J., Sun, Y.C., Lee, Y.C., Hou, Y.C., Hu, F.R. Curr. Eye Res. (2006) [Pubmed]
  11. Methylation of apoptosis related genes in the pathogenesis and prognosis of prostate cancer. Suzuki, M., Shigematsu, H., Shivapurkar, N., Reddy, J., Miyajima, K., Takahashi, T., Gazdar, A.F., Frenkel, E.P. Cancer Lett. (2006) [Pubmed]
 
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