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Gene Review

Lmo1  -  LIM domain only 1

Mus musculus

Synonyms: Cysteine-rich protein TTG-1, LIM domain only protein 1, LMO-1, Rbtn-1, Rbtn1, ...
 
 
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Disease relevance of Lmo1

 

High impact information on Lmo1

 

Biological context of Lmo1

 

Anatomical context of Lmo1

 

Associations of Lmo1 with chemical compounds

  • The LIM-only protein DRAL/FHL2 binds to the cytoplasmic domain of several alpha and beta integrin chains and is recruited to adhesion complexes [19].
 

Physical interactions of Lmo1

 

Other interactions of Lmo1

 

Analytical, diagnostic and therapeutic context of Lmo1

  • Our results complete the gene targeting of the LIM-only family in mice and suggest that all four members of this family are important in regulators of distinct developmental pathways [11].
  • Here, we assess this possibility by analysing rhombotin gene expression in mouse development by in situ hybridization of whole embryos, Northern filter hybridization, and a sensitive semiquantitative PCR method [16].
  • Based on protein sequence alignment, TLP is most closely related to the cysteine-rich proteins, a subclass of the family of LIM-only proteins [27].

References

  1. The LIM domain gene LMO4 inhibits differentiation of mammary epithelial cells in vitro and is overexpressed in breast cancer. Visvader, J.E., Venter, D., Hahm, K., Santamaria, M., Sum, E.Y., O'Reilly, L., White, D., Williams, R., Armes, J., Lindeman, G.J. Proc. Natl. Acad. Sci. U.S.A. (2001) [Pubmed]
  2. The t(11;14)(p15;q11) in a T-cell acute lymphoblastic leukemia cell line activates multiple transcripts, including Ttg-1, a gene encoding a potential zinc finger protein. McGuire, E.A., Hockett, R.D., Pollock, K.M., Bartholdi, M.F., O'Brien, S.J., Korsmeyer, S.J. Mol. Cell. Biol. (1989) [Pubmed]
  3. T-cell translocation gene 1 (Ttg-1) encodes a nuclear protein normally expressed in neural lineage cells. McGuire, E.A., Davis, A.R., Korsmeyer, S.J. Blood (1991) [Pubmed]
  4. Thymic overexpression of Ttg-1 in transgenic mice results in T-cell acute lymphoblastic leukemia/lymphoma. McGuire, E.A., Rintoul, C.E., Sclar, G.M., Korsmeyer, S.J. Mol. Cell. Biol. (1992) [Pubmed]
  5. Targeting expression of hsp70i to discrete neuronal populations using the Lmo-1 promoter: assessment of the neuroprotective effects of hsp70i in vivo and in vitro. Kelly, S., Bieneman, A., Horsburgh, K., Hughes, D., Sofroniew, M.V., McCulloch, J., Uney, J.B. J. Cereb. Blood Flow Metab. (2001) [Pubmed]
  6. MLP-deficient mice exhibit a disruption of cardiac cytoarchitectural organization, dilated cardiomyopathy, and heart failure. Arber, S., Hunter, J.J., Ross, J., Hongo, M., Sansig, G., Borg, J., Perriard, J.C., Chien, K.R., Caroni, P. Cell (1997) [Pubmed]
  7. Muscle LIM protein, a novel essential regulator of myogenesis, promotes myogenic differentiation. Arber, S., Halder, G., Caroni, P. Cell (1994) [Pubmed]
  8. The LIM-only protein FHL2 interacts with beta-catenin and promotes differentiation of mouse myoblasts. Martin, B., Schneider, R., Janetzky, S., Waibler, Z., Pandur, P., Kühl, M., Behrens, J., von der Mark, K., Starzinski-Powitz, A., Wixler, V. J. Cell Biol. (2002) [Pubmed]
  9. The oncogenic T cell LIM-protein Lmo2 forms part of a DNA-binding complex specifically in immature T cells. Grütz, G.G., Bucher, K., Lavenir, I., Larson, T., Larson, R., Rabbitts, T.H. EMBO J. (1998) [Pubmed]
  10. LIM-only protein, CRP2, switched on smooth muscle gene activity in adult cardiac myocytes. Chang, D.F., Belaguli, N.S., Chang, J., Schwartz, R.J. Proc. Natl. Acad. Sci. U.S.A. (2007) [Pubmed]
  11. Null mutation of the Lmo4 gene or a combined null mutation of the Lmo1/Lmo3 genes causes perinatal lethality, and Lmo4 controls neural tube development in mice. Tse, E., Smith, A.J., Hunt, S., Lavenir, I., Forster, A., Warren, A.J., Grutz, G., Foroni, L., Carlton, M.B., Colledge, W.H., Boehm, T., Rabbitts, T.H. Mol. Cell. Biol. (2004) [Pubmed]
  12. Characterization of the Lmo4 gene encoding a LIM-only protein: genomic organization and comparative chromosomal mapping. Tse, E., Grutz, G., Garner, A.A., Ramsey, Y., Carter, N.P., Copeland, N., Gilbert, D.J., Jenkins, N.A., Agulnick, A., Forster, A., Rabbitts, T.H. Mamm. Genome (1999) [Pubmed]
  13. The rhombotin family of cysteine-rich LIM-domain oncogenes: distinct members are involved in T-cell translocations to human chromosomes 11p15 and 11p13. Boehm, T., Foroni, L., Kaneko, Y., Perutz, M.F., Rabbitts, T.H. Proc. Natl. Acad. Sci. U.S.A. (1991) [Pubmed]
  14. The mouse homolog of the rhombotin (Ttg-1) gene maps on chromosome 7 distal to the beta-globin (Hbb) locus. Angel, J.M., Moore, J.L., Pelphrey, A., Richie, E.R. Mamm. Genome (1993) [Pubmed]
  15. Differential expression of LIM domain-only (LMO) genes in the developing mouse inner ear. Deng, M., Pan, L., Xie, X., Gan, L. Gene Expr. Patterns (2006) [Pubmed]
  16. Developmentally regulated and tissue specific expression of mRNAs encoding the two alternative forms of the LIM domain oncogene rhombotin: evidence for thymus expression. Boehm, T., Spillantini, M.G., Sofroniew, M.V., Surani, M.A., Rabbitts, T.H. Oncogene (1991) [Pubmed]
  17. Identification and characterization of Grainyhead-like epithelial transactivator (GET-1), a novel mammalian Grainyhead-like factor. Kudryavtseva, E.I., Sugihara, T.M., Wang, N., Lasso, R.J., Gudnason, J.F., Lipkin, S.M., Andersen, B. Dev. Dyn. (2003) [Pubmed]
  18. LIM genes parcellate the embryonic amygdala and regulate its development. Remedios, R., Subramanian, L., Tole, S. J. Neurosci. (2004) [Pubmed]
  19. The LIM-only protein DRAL/FHL2 binds to the cytoplasmic domain of several alpha and beta integrin chains and is recruited to adhesion complexes. Wixler, V., Geerts, D., Laplantine, E., Westhoff, D., Smyth, N., Aumailley, M., Sonnenberg, A., Paulsson, M. J. Biol. Chem. (2000) [Pubmed]
  20. Cloning and characterization of mCRIP2, a mouse LIM-only protein that interacts with PDZ domain IV of PTP-BL. van Ham, M., Croes, H., Schepens, J., Fransen, J., Wieringa, B., Hendriks, W. Genes Cells (2003) [Pubmed]
  21. Involvement of mitogen-activated protein kinase in the cytokine-regulated phosphorylation of transcription factor GATA-1. Towatari, M., Ciro, M., Ottolenghi, S., Tsuzuki, S., Enver, T. Hematol. J. (2004) [Pubmed]
  22. Design, production and characterization of FLIN2 and FLIN4: the engineering of intramolecular ldb1:LMO complexes. Deane, J.E., Sum, E., Mackay, J.P., Lindeman, G.J., Visvader, J.E., Matthews, J.M. Protein Eng. (2001) [Pubmed]
  23. The heart LIM protein gene (Hlp), expressed in the developing and adult heart, defines a new tissue-specific LIM-only protein family. Yu, T.S., Moctezuma-Anaya, M., Kubo, A., Keller, G., Robertson, S. Mech. Dev. (2002) [Pubmed]
  24. Expression patterns of FHL/SLIM family members suggest important functional roles in skeletal muscle and cardiovascular system. Chu, P.H., Ruiz-Lozano, P., Zhou, Q., Cai, C., Chen, J. Mech. Dev. (2000) [Pubmed]
  25. A family of LIM-only transcriptional coactivators: tissue-specific expression and selective activation of CREB and CREM. Fimia, G.M., De Cesare, D., Sassone-Corsi, P. Mol. Cell. Biol. (2000) [Pubmed]
  26. Identification and analysis of Hic-5/ARA55 isoforms: Implications for integrin signaling and steroid hormone action. Gao, Z., Schwartz, L.M. FEBS Lett. (2005) [Pubmed]
  27. Identification and characterization of thymus LIM protein: targeted disruption reduces thymus cellularity. Kirchner, J., Forbush, K.A., Bevan, M.J. Mol. Cell. Biol. (2001) [Pubmed]
 
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