Gene Review:
COPS5 - COP9 signalosome subunit 5
Homo sapiens
Synonyms:
COP9 signalosome complex subunit 5, CSN5, JAB1, Jun activation domain-binding protein 1, MOV-34, ...
- Jun activation domain-binding protein 1 expression in malignant lymphoma of the thyroid: its linkage to degree of malignancy and p27 expression. Ito, Y., Yoshida, H., Matsuzuka, F., Matsuura, N., Nakamura, Y., Nakamine, H., Kakudo, K., Kuma, K., Miyauchi, A. Anticancer Res. (2003)
- The S100A7-c-Jun activation domain binding protein 1 pathway enhances prosurvival pathways in breast cancer. Emberley, E.D., Niu, Y., Curtis, L., Troup, S., Mandal, S.K., Myers, J.N., Gibson, S.B., Murphy, L.C., Watson, P.H. Cancer Res. (2005)
- Interaction and colocalization of PGP9.5 with JAB1 and p27(Kip1). Caballero, O.L., Resto, V., Patturajan, M., Meerzaman, D., Guo, M.Z., Engles, J., Yochem, R., Ratovitski, E., Sidransky, D., Jen, J. Oncogene (2002)
- Skp2 and Jab1 expression are associated with inverse expression of p27(KIP1) and poor prognosis in oral squamous cell carcinomas. Shintani, S., Li, C., Mihara, M., Hino, S., Nakashiro, K., Hamakawa, H. Oncology (2003)
- Integrin LFA-1 interacts with the transcriptional co-activator JAB1 to modulate AP-1 activity. Bianchi, E., Denti, S., Granata, A., Bossi, G., Geginat, J., Villa, A., Rogge, L., Pardi, R. Nature (2000)
- Intracellular action of the cytokine MIF to modulate AP-1 activity and the cell cycle through Jab1. Kleemann, R., Hausser, A., Geiger, G., Mischke, R., Burger-Kentischer, A., Flieger, O., Johannes, F.J., Roger, T., Calandra, T., Kapurniotu, A., Grell, M., Finkelmeier, D., Brunner, H., Bernhagen, J. Nature (2000)
- p27kip1 functions as an anergy factor inhibiting interleukin 2 transcription and clonal expansion of alloreactive human and mouse helper T lymphocytes. Boussiotis, V.A., Freeman, G.J., Taylor, P.A., Berezovskaya, A., Grass, I., Blazar, B.R., Nadler, L.M. Nat. Med. (2000)
- Thioredoxin modulates activator protein 1 (AP-1) activity and p27Kip1 degradation through direct interaction with Jab1. Hwang, C.Y., Ryu, Y.S., Chung, M.S., Kim, K.D., Park, S.S., Chae, S.K., Chae, H.Z., Kwon, K.S. Oncogene (2004)
- Expression of cyclin-dependent kinase inhibitor p27/Kip1 and AP-1 coactivator p38/Jab1 correlates with differentiation of embryonal rhabdomyosarcoma. Tsuchida, R., Miyauchi, J., Shen, L., Takagi, M., Tsunematsu, Y., Saeki, M., Honna, T., Yamada, S., Teraoka, H., Kato, J.Y., Mizutani, S. Jpn. J. Cancer Res. (2002)
- Jun activation domain-binding protein 1 is required for mitotic checkpoint activation via its involvement in hyperphosphorylation of 53BP1. Kwak, H.J., Kim, S.H., Yoo, H.G., Park, S.H., Lee, C.H. J. Cancer Res. Clin. Oncol. (2005)
- The Jab1/COP9 signalosome subcomplex is a downstream mediator of Bcr-Abl kinase activity and facilitates cell-cycle progression. Tomoda, K., Kato, J.Y., Tatsumi, E., Takahashi, T., Matsuo, Y., Yoneda-Kato, N. Blood (2005)
- Interaction between glucose-regulated destruction domain of DNA topoisomerase IIalpha and MPN domain of Jab1/CSN5. Yun, J., Tomida, A., Andoh, T., Tsuruo, T. J. Biol. Chem. (2004)
- COP9 signalosome-specific phosphorylation targets p53 to degradation by the ubiquitin system. Bech-Otschir, D., Kraft, R., Huang, X., Henklein, P., Kapelari, B., Pollmann, C., Dubiel, W. EMBO J. (2001)
- Jab1 antagonizes TGF-beta signaling by inducing Smad4 degradation. Wan, M., Cao, X., Wu, Y., Bai, S., Wu, L., Shi, X., Wang, N., Cao, X. EMBO Rep. (2002)
- A new group of conserved coactivators that increase the specificity of AP-1 transcription factors. Claret, F.X., Hibi, M., Dhut, S., Toda, T., Karin, M. Nature (1996)
- Adapter protein NRBP associates with Jab1 and negatively regulates AP-1 activity. Wang, H., Sun, X., Luo, Y., Lin, Z., Wu, J. FEBS Lett. (2006)
- A novel protein complex involved in signal transduction possessing similarities to 26S proteasome subunits. Seeger, M., Kraft, R., Ferrell, K., Bech-Otschir, D., Dumdey, R., Schade, R., Gordon, C., Naumann, M., Dubiel, W. FASEB J. (1998)
- Jab1/CSN5, a component of the COP9 signalosome, regulates transforming growth factor beta signaling by binding to Smad7 and promoting its degradation. Kim, B.C., Lee, H.J., Park, S.H., Lee, S.R., Karpova, T.S., McNally, J.G., Felici, A., Lee, D.K., Kim, S.J. Mol. Cell. Biol. (2004)
- HER-2/neu transcriptionally activates Jab1 expression via the AKT/beta-catenin pathway in breast cancer cells. Hsu, M.C., Chang, H.C., Hung, W.C. Endocr. Relat. Cancer (2007)
- Overexpression of Jab1 in hepatocellular carcinoma and its inhibition by peroxisome proliferator-activated receptor{gamma} ligands in vitro and in vivo. Hsu, M.C., Huang, C.C., Chang, H.C., Hu, T.H., Hung, W.C. Clin. Cancer Res. (2008)
- JAB1 interacts with both the progesterone receptor and SRC-1. Chauchereau, A., Georgiakaki, M., Perrin-Wolff, M., Milgrom, E., Loosfelt, H. J. Biol. Chem. (2000)
- Jun activation domain-binding protein 1 expression in breast cancer inversely correlates with the cell cycle inhibitor p27(Kip1). Kouvaraki, M.A., Rassidakis, G.Z., Tian, L., Kumar, R., Kittas, C., Claret, F.X. Cancer Res. (2003)
- Jab1, a novel protease-activated receptor-2 (PAR-2)-interacting protein, is involved in PAR-2-induced activation of activator protein-1. Luo, W., Wang, Y., Hanck, T., Stricker, R., Reiser, G. J. Biol. Chem. (2006)