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Gene Review: 

KDELR2  -  KDEL (Lys-Asp-Glu-Leu) endoplasmic...

Homo sapiens

Synonyms: ELP-1, ER lumen protein retaining receptor 2, ERD2-like protein 1, ERD2.2, KDEL endoplasmic reticulum protein retention receptor 2, ...
 
 
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High impact information on KDELR2

  • When either human ERD-2 or a novel human homolog (referred to as ELP-1) is overexpressed in a variety of cell types, the effects are phenotypically indistinguishable from the addition of BFA [1].
  • A brefeldin A-like phenotype is induced by the overexpression of a human ERD-2-like protein, ELP-1 [1].
  • In the human testis, two rare transcripts were characterized, hELP1 and hELP2, the products of independent duplicated genes [2].
 

Biological context of KDELR2

  • 2. Inhibition of N-linked glycosylation of proteins by tunicamycin had no effect upon the levels of the single mRNA species recognized by the erd2.1 probe, or the multiple transcripts detected with the erd2.2 cDNA probe [3].
 

Analytical, diagnostic and therapeutic context of KDELR2

  • Genomic PCR analysis of three anthropoid species, chimpanzee, gorilla and orangutan, showed the presence of a similarly mutated hELP1 gene [2].

References

  1. A brefeldin A-like phenotype is induced by the overexpression of a human ERD-2-like protein, ELP-1. Hsu, V.W., Shah, N., Klausner, R.D. Cell (1992) [Pubmed]
  2. Progressive inactivation of the haploid expressed gene for the sperm-specific endozepine-like peptide (ELP) through primate evolution. Ivell, R., Pusch, W., Balvers, M., Valentin, M., Walther, N., Weinbauer, G. Gene (2000) [Pubmed]
  3. KDEL receptor expression is not coordinatedly up-regulated with ER stress-induced reticuloplasmin expression in HeLa cells. Llewellyn, D.H., Roderick, H.L., Rose, S. Biochem. Biophys. Res. Commun. (1997) [Pubmed]
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