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Gene Review: 

RAB35  -  RAB35, member RAS oncogene family

Homo sapiens

Synonyms: GTP-binding protein RAY, H-ray, RAB1C, RAY, Ras-related protein Rab-1C, ...
 
 
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High impact information on RAB35

  • Rab35 regulates an endocytic recycling pathway essential for the terminal steps of cytokinesis [1].
  • We propose that the Rab35-regulated pathway plays an essential role during the terminal steps of cytokinesis by controlling septin and PIP2 subcellular distribution during cell division [1].
  • We find that Rab35, whose function in membrane traffic was unknown, is localized to the plasma membrane and endocytic compartments and controls a fast endocytic recycling pathway [1].
  • Consistent with a key requirement for Rab35-regulated recycling during cell division, inhibition of Rab35 function leads to the accumulation of endocytic markers on numerous cytoplasmic vacuoles in cells that failed cytokinesis [1].
  • Rab1B, rab4B, rab5C, rab7, rab9, rab11B, and rab35 were identified from rat osteoclasts in this study [2].
 

Associations of RAB35 with chemical compounds

  • Moreover, Rab35 is involved in the intercellular bridge localization of two molecules essential for the postfurrowing steps of cytokinesis: the phosphatidylinositol 4,5-bis phosphate (PIP2) lipid and the septin SEPT2 [1].

References

  1. Rab35 regulates an endocytic recycling pathway essential for the terminal steps of cytokinesis. Kouranti, I., Sachse, M., Arouche, N., Goud, B., Echard, A. Curr. Biol. (2006) [Pubmed]
  2. Intracellular membrane trafficking pathways in bone-resorbing osteoclasts revealed by cloning and subcellular localization studies of small GTP-binding rab proteins. Zhao, H., Ettala, O., Väänänen, H.K. Biochem. Biophys. Res. Commun. (2002) [Pubmed]
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