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Gene Review

LILRA3  -  leukocyte immunoglobulin-like receptor,...

Homo sapiens

Synonyms: CD85 antigen-like family member E, CD85E, CD85e, HM31, HM43, ...
 
 
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Disease relevance of LILRA3

  • No differences in frequencies of the LILRA3 deletion were found between controls and patients or between HLA-Cw6(+) and HLA-Cw6(-) controls or patients, suggesting that LILRA3 has no role in psoriasis [1].
  • Association of multiple sclerosis with ILT6 deficiency [2].
  • These antigens were easily detected by SDS-PAGE of specific immunoprecipitates on a melanoma cell (HM31) which failed to reveal antigens reactive with the panel of murine monoclonal antibodies studied [3].
 

High impact information on LILRA3

  • The ILT genes were more stable in number except for ILT6, which was present only in one haplotype [4].
  • Downstream of exon 8 are three pseudo exons that are not included in any of the known ILT6 transcripts, but share high homology to the equivalent region in activating ILT loci, suggesting that these genes have evolved from a common ancestral sequence [5].
  • Arrangement of the ILT gene cluster: a common null allele of the ILT6 gene results from a 6.7-kbp deletion [5].
  • Long-term persistence of both functional and non-functional alleles at the leukocyte immunoglobulin-like receptor A3 (LILRA3) locus suggests balancing selection [6].
  • In this study, variation screening of the LILRA3 gene revealed high allele frequency of the 6.7-kb LILRA3 deletion (71%) in Japanese, in contrast to the frequency reported for the other populations [6].
 

Biological context of LILRA3

 

Anatomical context of LILRA3

  • If LILRA3 binds human leukocyte antigen (HLA) class I molecules like other LILRs whose ligands are known, then it might block recognition of HLA by these receptors, influencing immune response and susceptibility to HLA class I associated disease [1].
  • The allergenic potential of Lyc e 3-deficient tomato fruits was tested by measuring histamine release from sensitized human basophils stimulated with transgenic and parental lines [9].
 

Associations of LILRA3 with chemical compounds

 

Analytical, diagnostic and therapeutic context of LILRA3

  • Using PCR typing, deficiency of ILT6 was examined in 607 blood donors and in 751 Caucasian German, as well as 89 French MS patients [2].
  • Northern-blot and Western-blot analyses of poly(A)+ RNA and protein extracts, respectively, obtained from a variety of olive-tree-related and nonrelated mature pollens demonstrated the presence of Ole e 3 homologous proteins [10].
  • Molecular cloning and expression of active Ole e 3, a major allergen from olive-tree pollen and member of a novel family of Ca2+-binding proteins (polcalcins) involved in allergy [10].

References

  1. Distribution of LILRA3 (ILT6/LIR4) deletion in psoriatic patients and healthy controls. Wiśniewski, A., Łuszczek, W., Mańczak, M., Jasek, M., Kubicka, W., Cislo, M., Kuśnierczyk, P. Hum. Immunol. (2003) [Pubmed]
  2. Association of multiple sclerosis with ILT6 deficiency. Koch, S., Goedde, R., Nigmatova, V., Epplen, J.T., Müller, N., de Seze, J., Vermersch, P., Momot, T., Schmidt, R.E., Witte, T. Genes Immun. (2005) [Pubmed]
  3. Comparison of cell-surface human melanoma-associated antigens identified by rabbit and murine antibodies. Bystryn, J.C., Jacobsen, J.S., Liu, P., Heaney-Kieras, J. Hybridoma (1982) [Pubmed]
  4. Plasticity in the organization and sequences of human KIR/ILT gene families. Wilson, M.J., Torkar, M., Haude, A., Milne, S., Jones, T., Sheer, D., Beck, S., Trowsdale, J. Proc. Natl. Acad. Sci. U.S.A. (2000) [Pubmed]
  5. Arrangement of the ILT gene cluster: a common null allele of the ILT6 gene results from a 6.7-kbp deletion. Torkar, M., Haude, A., Milne, S., Beck, S., Trowsdale, J., Wilson, M.J. Eur. J. Immunol. (2000) [Pubmed]
  6. Long-term persistence of both functional and non-functional alleles at the leukocyte immunoglobulin-like receptor A3 (LILRA3) locus suggests balancing selection. Hirayasu, K., Ohashi, J., Kashiwase, K., Takanashi, M., Satake, M., Tokunaga, K., Yabe, T. Hum. Genet. (2006) [Pubmed]
  7. Analysis of candidate genes on chromosome 19 in coeliac disease: an association study of the KIR and LILR gene clusters. Moodie, S.J., Norman, P.J., King, A.L., Fraser, J.S., Curtis, D., Ellis, H.J., Vaughan, R.W., Ciclitira, P.J. Eur. J. Immunogenet. (2002) [Pubmed]
  8. DNA sequence variation and molecular genotyping of natural killer leukocyte immunoglobulin-like receptor, LILRA3. Norman, P.J., Carey, B.S., Stephens, H.A., Vaughan, R.W. Immunogenetics (2003) [Pubmed]
  9. Design of tomato fruits with reduced allergenicity by dsRNAi-mediated inhibition of ns-LTP (Lyc e 3) expression. Le, L.Q., Lorenz, Y., Scheurer, S., F??tisch, K., Enrique, E., Bartra, J., Biemelt, S., Vieths, S., Sonnewald, U. Plant Biotechnol. J. (2006) [Pubmed]
  10. Molecular cloning and expression of active Ole e 3, a major allergen from olive-tree pollen and member of a novel family of Ca2+-binding proteins (polcalcins) involved in allergy. Ledesma, A., Villalba, M., Batanero, E., Rodríguez, R. Eur. J. Biochem. (1998) [Pubmed]
 
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