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Dgkq  -  diacylglycerol kinase, theta

Mus musculus

Synonyms: 110kDa, DAG kinase theta, DAGK, DAGK7, DGK-theta, ...
 
 
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High impact information on Dgkq

  • These results suggest that nuclear DAG kinase plays a key role in regulating the levels of DAG present in the nucleus and that DAG is a key molecule for the mitogenic effect that IGF-I exerts on Swiss 3T3 cells [1].
  • Treatment of cells with two DAG kinase inhibitors, R59022 and R59949, blocked the IGF-I-dependent rise in nuclear DAG kinase activity and maintained elevated intranuclear levels of DAG [1].
  • Previous evidence has shown that the nucleus also contains DAG kinase, i.e., the enzyme that yields phosphatidic acid from DAG, thus terminating PKC-mediated signaling events [1].
  • This was confirmed by the stimulation of PA (without ATP) by GTP[S], effectively excluding phosphorylation of DAG by DAG kinase in the formation of PA [2].
  • A similar loss of InsP production upon stimulation of keratinocytes with 1.4 mM Ca2+ was seen after pretreatment with R59022, a DAG kinase inhibitor [3].
 

Anatomical context of Dgkq

 

Associations of Dgkq with chemical compounds

  • One gene in the interval, Dagk4 at 57 cM, is polymorphic for C3 and B6 mice [4].
  • Levels of PA which were lower than would be predicted by DAG kinase activation are explained by increased phosphatidate phosphohydrolase activity [5].
  • In protein kinase C-depleted cells, addition of a cell-permeable synthetic diacylglycerol, dioctanoylglycerol, results in a partial redistribution of cytosolic diacylglycerol kinase to the membrane, also suggesting that the translocation of DAG kinase is regulated primarily by substrate concentration [6].
  • First, we found that thiazolidinedione compounds could inhibit PKC activation by activating DAG kinase [7].
 

Other interactions of Dgkq

  • In the present study, DAG kinase with 80 kDa mass (80K DGK) has been successfully transfected in DT cells, which exhibited enhanced cellular DAG kinase activities, decreased cellular DAG contents, and increased PKC activities compared to the control vector-transfected cells [8].
  • Specific inhibitors of EGFR kinase and DAG kinase suppressed DAG kinase activation and PA production by EGFRvIII [5].
  • After IGF-I treatment, maximal enhancement of DAG kinase activity was measured in the internal matrix domain of the nucleus [1].

References

  1. Enhanced nuclear diacylglycerol kinase activity in response to a mitogenic stimulation of quiescent Swiss 3T3 cells with insulin-like growth factor I. Martelli, A.M., Tabellini, G., Bortul, R., Manzoli, L., Bareggi, R., Baldini, G., Grill, V., Zweyer, M., Narducci, P., Cocco, L. Cancer Res. (2000) [Pubmed]
  2. Erythropoietin stimulates G-protein-coupled phospholipase D in haematopoietic target cells. Clejan, S., Mallia, C., Vinson, D., Dotson, R., Beckman, B.S. Biochem. J. (1996) [Pubmed]
  3. Effects of prolonged EGF treatment on phospholipid turnover and DAG formation in murine keratinocytes. Punnonen, K., Isoherranen, K., Laihia, J., Leino, L. Cell. Signal. (1996) [Pubmed]
  4. Hypercapnic duty cycle is an intermediate physiological phenotype linked to mouse chromosome 5. Schneider, H., Patil, S.P., Canisius, S., Gladmon, E.A., Schwartz, A.R., O'Donnell, C.P., Smith, P.L., Tankersley, C.G. J. Appl. Physiol. (2003) [Pubmed]
  5. Epidermal growth factor receptor stimulation of diacylglycerol kinase. Montgomery, R.B., Moscatello, D.K., Wong, A.J., Stahl, W.L. Biochem. Biophys. Res. Commun. (1997) [Pubmed]
  6. Translocation of diacylglycerol kinase from the cytosol to the membrane in phorbol ester-treated Swiss 3T3 fibroblasts. Maroney, A.C., Macara, I.G. J. Cell. Biochem. (1989) [Pubmed]
  7. Cellular mechanisms in the development and progression of diabetic nephropathy: activation of the DAG-PKC-ERK pathway. Haneda, M., Koya, D., Kikkawa, R. Am. J. Kidney Dis. (2001) [Pubmed]
  8. Abolishment of bradykinin-induced calcium oscillations in ras-transformed fibroblasts by the expression of 80 kDa diacylglycerol kinase. Fu, T., Sugimoto, Y., Okano, Y., Kanoh, H., Nozawa, Y. FEBS Lett. (1992) [Pubmed]
 
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