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DNAJB4  -  DnaJ (Hsp40) homolog, subfamily B, member 4

Homo sapiens

Synonyms: DNAJW, DjB4, DnaJ homolog subfamily B member 4, HLJ1, HSP40 homolog, ...
 
 
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Disease relevance of DNAJB4

  • A serial deletion of the 1.2 kb at the 5'-flanking region of the human HLJ1 gene was subcloned into a vector containing reporter gene and transfected into human lung adenocarcinoma cell line CL1-0, followed by luciferase activity assay [1].
  • By using microarray and an invasion/metastasis lung cell line model, we identified the DnaJ-like heat shock protein 40, HLJ1, and found that the expression of HLJ1 correlates negatively with cancer cell invasion ability [1].
  • Here, we investigated the clinical significance of HLJ1 expression in non-small-cell lung cancer (NSCLC) patients and its role in cancer progression [2].
  • A new tumor suppressor DnaJ-like heat shock protein, HLJ1, and survival of patients with non-small-cell lung carcinoma [2].
 

High impact information on DNAJB4

  • In addition, fungi possess a specialized Hsp70 system attached to ribosomes, which in Saccharomyces cerevisiae consists of the Hsp70 homologs Ssb1/2p, Ssz1p, and the Hsp40 homolog zuotin [3].
  • Our results, together with the current structural information of the Hsp40 C-terminal and J-domains, were used to generate models of the internal structural organization of DjA1 and DjB4 [4].
  • The transcriptional factor YY1 upregulates the novel invasion suppressor HLJ1 expression and inhibits cancer cell invasion [1].
  • We further characterize the putative promoter region and investigate the transcriptional regulations of human HLJ1 [1].
  • The increase in HLJ1 and E-cadherin expression, as well as the suppression of invasion ability, can be reversed specifically by HLJ1 siRNA [1].
 

Biological context of DNAJB4

 

Anatomical context of DNAJB4

  • Northern analysis showed that expression of the HLJ1 gene is heat-inducible and its transcription shows some degree of preference in heart, skeletal muscle, and pancreas [5].
 

Other interactions of DNAJB4

  • Furthermore, we also demonstrated that overexpression of YY1 in CL1-0 cells can increase HLJ1 expression and reduce cell invasive capability [1].
 

Analytical, diagnostic and therapeutic context of DNAJB4

References

  1. The transcriptional factor YY1 upregulates the novel invasion suppressor HLJ1 expression and inhibits cancer cell invasion. Wang, C.C., Tsai, M.F., Hong, T.M., Chang, G.C., Chen, C.Y., Yang, W.M., Chen, J.J., Yang, P.C. Oncogene (2005) [Pubmed]
  2. A new tumor suppressor DnaJ-like heat shock protein, HLJ1, and survival of patients with non-small-cell lung carcinoma. Tsai, M.F., Wang, C.C., Chang, G.C., Chen, C.Y., Chen, H.Y., Cheng, C.L., Yang, Y.P., Wu, C.Y., Shih, F.Y., Liu, C.C., Lin, H.P., Jou, Y.S., Lin, S.C., Lin, C.W., Chen, W.J., Chan, W.K., Chen, J.J., Yang, P.C. J. Natl. Cancer Inst. (2006) [Pubmed]
  3. The chaperones MPP11 and Hsp70L1 form the mammalian ribosome-associated complex. Otto, H., Conz, C., Maier, P., Wölfle, T., Suzuki, C.K., Jenö, P., Rücknagel, P., Stahl, J., Rospert, S. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  4. Low resolution structural study of two human HSP40 chaperones in solution. DJA1 from subfamily A and DJB4 from subfamily B have different quaternary structures. Borges, J.C., Fischer, H., Craievich, A.F., Ramos, C.H. J. Biol. Chem. (2005) [Pubmed]
  5. Isolation of a new member of DnaJ-like heat shock protein 40 (Hsp40) from human liver. Hoe, K.L., Won, M., Chung, K.S., Jang, Y.J., Lee, S.B., Kim, D.U., Lee, J.W., Yun, J.H., Yoo, H.S. Biochim. Biophys. Acta (1998) [Pubmed]
 
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