Gene Review:
PSIP1 - PC4 and SFRS1 interacting protein 1
Homo sapiens
Synonyms:
CLL-associated antigen KW-7, DFS 70, DFS70, Dense fine speckles 70 kDa protein, LEDGF, ...
- Identification of an evolutionarily conserved domain in human lens epithelium-derived growth factor/transcriptional co-activator p75 (LEDGF/p75) that binds HIV-1 integrase. Cherepanov, P., Devroe, E., Silver, P.A., Engelman, A. J. Biol. Chem. (2004)
- Disruption of ledgf/psip1 results in perinatal mortality and homeotic skeletal transformations. Sutherland, H.G., Newton, K., Brownstein, D.G., Holmes, M.C., Kress, C., Semple, C.A., Bickmore, W.A. Mol. Cell. Biol. (2006)
- Identification and characterization of a functional nuclear localization signal in the HIV-1 integrase interactor LEDGF/p75. Maertens, G., Cherepanov, P., Debyser, Z., Engelborghs, Y., Engelman, A. J. Biol. Chem. (2004)
- Lens epithelium-derived growth factor/p75 prevents proteasomal degradation of HIV-1 integrase. Llano, M., Delgado, S., Vanegas, M., Poeschla, E.M. J. Biol. Chem. (2004)
- The interaction of LEDGF/p75 with integrase is lentivirus-specific and promotes DNA binding. Busschots, K., Vercammen, J., Emiliani, S., Benarous, R., Engelborghs, Y., Christ, F., Debyser, Z. J. Biol. Chem. (2005)
- Regulation of p53 tumour suppressor target gene expression by the p52 NF-kappaB subunit. Schumm, K., Rocha, S., Caamano, J., Perkins, N.D. EMBO J. (2006)
- Disruption of mitochondrial function during apoptosis is mediated by caspase cleavage of the p75 subunit of complex I of the electron transport chain. Ricci, J.E., Muñoz-Pinedo, C., Fitzgerald, P., Bailly-Maitre, B., Perkins, G.A., Yadava, N., Scheffler, I.E., Ellisman, M.H., Green, D.R. Cell (2004)
- The protean actions of neurotrophins and their receptors on the life and death of neurons. Kalb, R. Trends Neurosci. (2005)
- Modulation of NF-kappaB activity by exchange of dimers. Saccani, S., Pantano, S., Natoli, G. Mol. Cell (2003)
- Purification of a polypeptide complex (p52) belonging to the D-subspecificites of Epstein-Barr virus-induced early antigens. Dölken, G., Hecht, T., Weitzmann, U., Wagner, M., Löhr, G.W., Hirsch, F.W. Virology (1986)
- Constitutively tyrosine phosphorylated p52 Shc in breast cancer cells: correlation with ErbB2 and p66 Shc expression. Stevenson, L.E., Frackelton, A.R. Breast Cancer Res. Treat. (1998)
- Phenotype-dependent susceptibility of cholinergic neuroblastoma cells to neurotoxic inputs. Szutowicz, A., Bielarczyk, H., Gul, S., Ronowska, A., Pawe??czyk, T., Jankowska-Kulawy, A. Metabolic brain disease (2006)
- Sodium-n-butyrate induces secretion and substrate accumulation of p52 in Kirsten sarcoma virus-transformed rat kidney fibroblasts. Ryan, M.P., Higgins, P.J. Int. J. Biochem. (1989)
- IgM serum antibodies to Epstein-Barr virus are uniquely present in a subset of patients with the chronic fatigue syndrome. Lerner, A.M., Beqaj, S.H., Deeter, R.G., Fitzgerald, J.T. In Vivo (2004)
- A novel transcriptional coactivator, p52, functionally interacts with the essential splicing factor ASF/SF2. Ge, H., Si, Y., Wolffe, A.P. Mol. Cell (1998)
- Transactivation of involucrin, a marker of differentiation in keratinocytes, by lens epithelium-derived growth factor (LEDGF). Kubo, E., Fatma, N., Sharma, P., Shinohara, T., Chylack, L.T., Akagi, Y., Singh, D.P. J. Mol. Biol. (2002)
- Caspase cleavage of the nuclear autoantigen LEDGF/p75 abrogates its pro-survival function: implications for autoimmunity in atopic disorders. Wu, X., Daniels, T., Molinaro, C., Lilly, M.B., Casiano, C.A. Cell Death Differ. (2002)
- Transient and stable knockdown of the integrase cofactor LEDGF/p75 reveals its role in the replication cycle of human immunodeficiency virus. Vandekerckhove, L., Christ, F., Van Maele, B., De Rijck, J., Gijsbers, R., Van den Haute, C., Witvrouw, M., Debyser, Z. J. Virol. (2006)
- Identification of the LEDGF/p75 HIV-1 integrase-interaction domain and NLS reveals NLS-independent chromatin tethering. Vanegas, M., Llano, M., Delgado, S., Thompson, D., Peretz, M., Poeschla, E. J. Cell. Sci. (2005)
- Differential regulation of NF-kappaB2(p100) processing and control by amino-terminal sequences. Betts, J.C., Nabel, G.J. Mol. Cell. Biol. (1996)
- Identification and characterization of the chromatin-binding domains of the HIV-1 integrase interactor LEDGF/p75. Llano, M., Vanegas, M., Hutchins, N., Thompson, D., Delgado, S., Poeschla, E.M. J. Mol. Biol. (2006)
- Transcriptional regulation of the antioxidant protein 2 gene, a thiol-specific antioxidant, by lens epithelium-derived growth factor to protect cells from oxidative stress. Fatma, N., Singh, D.P., Shinohara, T., Chylack, L.T. J. Biol. Chem. (2001)
- Lens epithelium-derived growth factor relieves transforming growth factor-beta1-induced transcription repression of heat shock proteins in human lens epithelial cells. Sharma, P., Fatma, N., Kubo, E., Shinohara, T., Chylack, L.T., Singh, D.P. J. Biol. Chem. (2003)
- Biochemical and genetic analyses of integrase-interacting proteins lens epithelium-derived growth factor (LEDGF)/p75 and hepatoma-derived growth factor related protein 2 (HRP2) in preintegration complex function and HIV-1 replication. Vandegraaff, N., Devroe, E., Turlure, F., Silver, P.A., Engelman, A. Virology (2006)
- NUP98-LEDGF fusion and t(9;11) in transformed chronic myeloid leukemia. Grand, F.H., Koduru, P., Cross, N.C., Allen, S.L. Leuk. Res. (2005)
- Autoantibodies to DFS 70 kd/transcription coactivator p75 in atopic dermatitis and other conditions. Ochs, R.L., Muro, Y., Si, Y., Ge, H., Chan, E.K., Tan, E.M. J. Allergy Clin. Immunol. (2000)
- Autoantibodies to DFS70/LEDGF are increased in alopecia areata patients. Okamoto, M., Ogawa, Y., Watanabe, A., Sugiura, K., Shimomura, Y., Aoki, N., Nagasaka, T., Tomita, Y., Muro, Y. J. Autoimmun. (2004)
- Autoantigenicity of DFS70 is restricted to the conformational epitope of C-terminal alpha-helical domain. Ogawa, Y., Sugiura, K., Watanabe, A., Kunimatsu, M., Mishima, M., Tomita, Y., Muro, Y. J. Autoimmun. (2004)
- Lens epithelium-derived growth factor (LEDGF/p75) expression in fetal and adult human brain. Chylack, L.T., Fu, L., Mancini, R., Martin-Rehrmann, M.D., Saunders, A.J., Konopka, G., Tian, D., Hedley-Whyte, E.T., Folkerth, R.D., Goldstein, L.E. Exp. Eye Res. (2004)