Gene Review:
CHEK2 - checkpoint kinase 2
Homo sapiens
Synonyms:
CDS1, CHK2, CHK2 checkpoint homolog, Cds1 homolog, Checkpoint kinase 2, ...
Takeuchi,
Klijn,
Vegesna,
De Ruyck,
Casagrande,
Ducommun,
Krol-Warmerdam,
Willems,
Hofmann,
Huiping,
Vral,
Tollenaar,
Schutte,
Sigbjornsdottir,
Hafsteinsdottir,
Ikezoe,
Thierens,
Tsukasaki,
Bergthorsson,
Ragnarsson,
Blom,
Escalas,
Egilsson,
de Bock,
Meijers-Heijboer,
Krug,
Cornelisse,
Seynaeve,
Koeffler,
Brekelmans,
van Asperen,
Penary,
Baeyens,
Tavor,
Ingvarsson,
Arason,
Baudouin,
Goubin-Gramatica,
Claes,
Barkardottir,
Devilee,
Darbon,
Miller,
- Low-penetrance susceptibility to breast cancer due to CHEK2(*)1100delC in noncarriers of BRCA1 or BRCA2 mutations. Meijers-Heijboer, H., van den Ouweland, A., Klijn, J., Wasielewski, M., de Snoo, A., Oldenburg, R., Hollestelle, A., Houben, M., Crepin, E., van Veghel-Plandsoen, M., Elstrodt, F., van Duijn, C., Bartels, C., Meijers, C., Schutte, M., McGuffog, L., Thompson, D., Easton, D., Sodha, N., Seal, S., Barfoot, R., Mangion, J., Chang-Claude, J., Eccles, D., Eeles, R., Evans, D.G., Houlston, R., Murday, V., Narod, S., Peretz, T., Peto, J., Phelan, C., Zhang, H.X., Szabo, C., Devilee, P., Goldgar, D., Futreal, P.A., Nathanson, K.L., Weber, B., Rahman, N., Stratton, M.R. Nat. Genet. (2002)
- Mutations in CHEK2 associated with prostate cancer risk. Dong, X., Wang, L., Taniguchi, K., Wang, X., Cunningham, J.M., McDonnell, S.K., Qian, C., Marks, A.F., Slager, S.L., Peterson, B.J., Smith, D.I., Cheville, J.C., Blute, M.L., Jacobsen, S.J., Schaid, D.J., Tindall, D.J., Thibodeau, S.N., Liu, W. Am. J. Hum. Genet. (2003)
- A CHEK2 genetic variant contributing to a substantial fraction of familial breast cancer. Vahteristo, P., Bartkova, J., Eerola, H., Syrjäkoski, K., Ojala, S., Kilpivaara, O., Tamminen, A., Kononen, J., Aittomäki, K., Heikkilä, P., Holli, K., Blomqvist, C., Bartek, J., Kallioniemi, O.P., Nevanlinna, H. Am. J. Hum. Genet. (2002)
- The CHEK2 1100delC mutation identifies families with a hereditary breast and colorectal cancer phenotype. Meijers-Heijboer, H., Wijnen, J., Vasen, H., Wasielewski, M., Wagner, A., Hollestelle, A., Elstrodt, F., van den Bos, R., de Snoo, A., Fat, G.T., Brekelmans, C., Jagmohan, S., Franken, P., Verkuijlen, P., van den Ouweland, A., Chapman, P., Tops, C., Möslein, G., Burn, J., Lynch, H., Klijn, J., Fodde, R., Schutte, M. Am. J. Hum. Genet. (2003)
- Variants in the ATM-BRCA2-CHEK2 axis predispose to chronic lymphocytic leukemia. Rudd, M.F., Sellick, G.S., Webb, E.L., Catovsky, D., Houlston, R.S. Blood (2006)
- CHEK2 1100delC is a susceptibility allele for HNPCC-related colorectal cancer. Wasielewski, M., Vasen, H., Wijnen, J., Hooning, M., Dooijes, D., Tops, C., Klijn, J.G., Meijers-Heijboer, H., Schutte, M. Clin. Cancer Res. (2008)
- A role for the deubiquitinating enzyme USP28 in control of the DNA-damage response. Zhang, D., Zaugg, K., Mak, T.W., Elledge, S.J. Cell (2006)
- The mismatch repair system is required for S-phase checkpoint activation. Brown, K.D., Rathi, A., Kamath, R., Beardsley, D.I., Zhan, Q., Mannino, J.L., Baskaran, R. Nat. Genet. (2003)
- The DNA damage-dependent intra-S phase checkpoint is regulated by parallel pathways. Falck, J., Petrini, J.H., Williams, B.R., Lukas, J., Bartek, J. Nat. Genet. (2002)
- MDC1 is coupled to activated CHK2 in mammalian DNA damage response pathways. Lou, Z., Minter-Dykhouse, K., Wu, X., Chen, J. Nature (2003)
- DNA damage-induced cell cycle regulation and function of novel chk2 phosphoresidues. Buscemi, G., Carlessi, L., Zannini, L., Lisanti, S., Fontanella, E., Canevari, S., Delia, D. Mol. Cell. Biol. (2006)
- Inducible degradation of checkpoint kinase 2 links to cisplatin-induced resistance in ovarian cancer cells. Zhang, P., Gao, W., Li, H., Reed, E., Chen, F. Biochem. Biophys. Res. Commun. (2005)
- Distinct Chk2 activation pathways are triggered by genistein and DNA-damaging agents in human melanoma cells. Darbon, J.M., Penary, M., Escalas, N., Casagrande, F., Goubin-Gramatica, F., Baudouin, C., Ducommun, B. J. Biol. Chem. (2000)
- Aberrations of the CHK2 gene are rare in pediatric solid tumors. Chen, Y.Y., Takita, J., Tanaka, K., Ida, K., Koh, K., Igarashi, T., Hanada, R., Kikuchi, A., Tanaka, Y., Toyoda, Y., Hayashi, Y. Int. J. Mol. Med. (2005)
- Ccr4 contributes to tolerance of replication stress through control of CRT1 mRNA poly(A) tail length. Woolstencroft, R.N., Beilharz, T.H., Cook, M.A., Preiss, T., Durocher, D., Tyers, M. J. Cell. Sci. (2006)
- CHEK2 is a multiorgan cancer susceptibility gene. Cybulski, C., Górski, B., Huzarski, T., Masojć, B., Mierzejewski, M., Debniak, T., Teodorczyk, U., Byrski, T., Gronwald, J., Matyjasik, J., Zlowocka, E., Lenner, M., Grabowska, E., Nej, K., Castaneda, J., Medrek, K., Szymańska, A., Szymańska, J., Kurzawski, G., Suchy, J., Oszurek, O., Witek, A., Narod, S.A., Lubiński, J. Am. J. Hum. Genet. (2004)
- Functional and genomic approaches reveal an ancient CHEK2 allele associated with breast cancer in the Ashkenazi Jewish population. Shaag, A., Walsh, T., Renbaum, P., Kirchhoff, T., Nafa, K., Shiovitz, S., Mandell, J.B., Welcsh, P., Lee, M.K., Ellis, N., Offit, K., Levy-Lahad, E., King, M.C. Hum. Mol. Genet. (2005)
- Alternative splicing and mutation status of CHEK2 in stage III breast cancer. Staalesen, V., Falck, J., Geisler, S., Bartkova, J., Børresen-Dale, A.L., Lukas, J., Lillehaug, J.R., Bartek, J., Lønning, P.E. Oncogene (2004)
- Correlation of CHEK2 protein expression and c.1100delC mutation status with tumor characteristics among unselected breast cancer patients. Kilpivaara, O., Bartkova, J., Eerola, H., Syrjäkoski, K., Vahteristo, P., Lukas, J., Blomqvist, C., Holli, K., Heikkilä, P., Sauter, G., Kallioniemi, O.P., Bartek, J., Nevanlinna, H. Int. J. Cancer (2005)
- Regulation of CHK2 by DNA-dependent protein kinase. Li, J., Stern, D.F. J. Biol. Chem. (2005)
- Homozygosity for a CHEK2*1100delC mutation identified in familial colorectal cancer does not lead to a severe clinical phenotype. van Puijenbroek, M., van Asperen, C.J., van Mil, A., Devilee, P., van Wezel, T., Morreau, H. J. Pathol. (2005)
- hCds1-mediated phosphorylation of BRCA1 regulates the DNA damage response. Lee, J.S., Collins, K.M., Brown, A.L., Lee, C.H., Chung, J.H. Nature (2000)
- Ataxia telangiectasia-mutated phosphorylates Chk2 in vivo and in vitro. Matsuoka, S., Rotman, G., Ogawa, A., Shiloh, Y., Tamai, K., Elledge, S.J. Proc. Natl. Acad. Sci. U.S.A. (2000)
- Mutations of the CHK2 gene are found in some osteosarcomas, but are rare in breast, lung, and ovarian tumors. Miller, C.W., Ikezoe, T., Krug, U., Hofmann, W.K., Tavor, S., Vegesna, V., Tsukasaki, K., Takeuchi, S., Koeffler, H.P. Genes Chromosomes Cancer (2002)
- Methylator-induced, mismatch repair-dependent G2 arrest is activated through Chk1 and Chk2. Adamson, A.W., Beardsley, D.I., Kim, W.J., Gao, Y., Baskaran, R., Brown, K.D. Mol. Biol. Cell (2005)
- Genotoxic stress-induced activation of Plk3 is partly mediated by Chk2. Xie, S., Wu, H., Wang, Q., Kunicki, J., Thomas, R.O., Hollingsworth, R.E., Cogswell, J., Dai, W. Cell Cycle (2002)
- Structural and functional versatility of the FHA domain in DNA-damage signaling by the tumor suppressor kinase Chk2. Li, J., Williams, B.L., Haire, L.F., Goldberg, M., Wilker, E., Durocher, D., Yaffe, M.B., Jackson, S.P., Smerdon, S.J. Mol. Cell (2002)
- Role of human Cds1 (Chk2) kinase in DNA damage checkpoint and its regulation by p53. Tominaga, K., Morisaki, H., Kaneko, Y., Fujimoto, A., Tanaka, T., Ohtsubo, M., Hirai, M., Okayama, H., Ikeda, K., Nakanishi, M. J. Biol. Chem. (1999)
- TTK/hMps1 participates in the regulation of DNA damage checkpoint response by phosphorylating CHK2 on threonine 68. Wei, J.H., Chou, Y.F., Ou, Y.H., Yeh, Y.H., Tyan, S.W., Sun, T.P., Shen, C.Y., Shieh, S.Y. J. Biol. Chem. (2005)
- HDM2 negatively affects the Chk2-mediated phosphorylation of p53. Bjørling-Poulsen, M., Meek, D., Issinger, O.G. FEBS Lett. (2005)
- Chk2 activates E2F-1 in response to DNA damage. Stevens, C., Smith, L., La Thangue, N.B. Nat. Cell Biol. (2003)
- The hCds1 (Chk2)-FHA domain is essential for a chain of phosphorylation events on hCds1 that is induced by ionizing radiation. Lee, C.H., Chung, J.H. J. Biol. Chem. (2001)
- PML-dependent apoptosis after DNA damage is regulated by the checkpoint kinase hCds1/Chk2. Yang, S., Kuo, C., Bisi, J.E., Kim, M.K. Nat. Cell Biol. (2002)
- Mutation analysis of the CHK2 gene in breast carcinoma and other cancers. Ingvarsson, S., Sigbjornsdottir, B.I., Huiping, C., Hafsteinsdottir, S.H., Ragnarsson, G., Barkardottir, R.B., Arason, A., Egilsson, V., Bergthorsson, J.T. Breast Cancer Res. (2002)
- Differential mode of regulation of the checkpoint kinases CHK1 and CHK2 by their regulatory domains. Ng, C.P., Lee, H.C., Ho, C.W., Arooz, T., Siu, W.Y., Lau, A., Poon, R.Y. J. Biol. Chem. (2004)
- The cell cycle checkpoint kinase Chk2 is a negative regulator of mitotic catastrophe. Castedo, M., Perfettini, J.L., Roumier, T., Yakushijin, K., Horne, D., Medema, R., Kroemer, G. Oncogene (2004)
- The Wip1 phosphatase (PPM1D) antagonizes activation of the Chk2 tumour suppressor kinase. Oliva-Trastoy, M., Berthonaud, V., Chevalier, A., Ducrot, C., Marsolier-Kergoat, M.C., Mann, C., Leteurtre, F. Oncogene (2007)
- Tachpyridine, a metal chelator, induces G2 cell-cycle arrest, activates checkpoint kinases, and sensitizes cells to ionizing radiation. Turner, J., Koumenis, C., Kute, T.E., Planalp, R.P., Brechbiel, M.W., Beardsley, D., Cody, B., Brown, K.D., Torti, F.M., Torti, S.V. Blood (2005)
- Chk2 activation dependence on Nbs1 after DNA damage. Buscemi, G., Savio, C., Zannini, L., Miccichè, F., Masnada, D., Nakanishi, M., Tauchi, H., Komatsu, K., Mizutani, S., Khanna, K., Chen, P., Concannon, P., Chessa, L., Delia, D. Mol. Cell. Biol. (2001)
- Immunohistochemical expression of DNA repair proteins in familial breast cancer differentiate BRCA2-associated tumors. Honrado, E., Osorio, A., Palacios, J., Milne, R.L., Sánchez, L., Díez, O., Cazorla, A., Syrjakoski, K., Huntsman, D., Heikkilä, P., Lerma, E., Kallioniemi, A., Rivas, C., Foulkes, W.D., Nevanlinna, H., Benítez, J. J. Clin. Oncol. (2005)
- Low frequency of CHEK2 1100delC allele in Australian multiple-case breast cancer families: functional analysis in heterozygous individuals. Jekimovs, C.R., Chen, X., Arnold, J., Gatei, M., Richard, D.J., Spurdle, A.B., Khanna, K.K., Chenevix-Trench, G. Br. J. Cancer (2005)
- Colorectal cancer and the CHEK2 1100delC mutation. de Jong, M.M., Nolte, I.M., Te Meerman, G.J., van der Graaf, W.T., Mulder, M.J., van der Steege, G., Bruinenberg, M., Schaapveld, M., Niessen, R.C., Berends, M.J., Sijmons, R.H., Hofstra, R.M., de Vries, E.G., Kleibeuker, J.H. Genes Chromosomes Cancer (2005)
- Chromosomal radiosensitivity of breast cancer with a CHEK2 mutation. Baeyens, A., Claes, K., Willems, P., De Ruyck, K., Thierens, H., Vral, A. Cancer Genet. Cytogenet. (2005)
- Tumour characteristics and prognosis of breast cancer patients carrying the germline CHEK2*1100delC variant. de Bock, G.H., Schutte, M., Krol-Warmerdam, E.M., Seynaeve, C., Blom, J., Brekelmans, C.T., Meijers-Heijboer, H., van Asperen, C.J., Cornelisse, C.J., Devilee, P., Tollenaar, R.A., Klijn, J.G. J. Med. Genet. (2004)