Gene Review:
Nrg1 - neuregulin 1
Rattus norvegicus
Synonyms:
Ndf, Pro-NRG1, Pro-neuregulin-1, membrane-bound isoform
- Neuregulin-1 reduces ischemia-induced brain damage in rats. Shyu, W.C., Lin, S.Z., Chiang, M.F., Yang, H.I., Thajeb, P., Li, H. Neurobiol. Aging (2004)
- Constitutive activation of the neuregulin-1/ErbB receptor signaling pathway is essential for the proliferation of a neoplastic Schwann cell line. Frohnert, P.W., Stonecypher, M.S., Carroll, S.L. Glia (2003)
- Neuregulin1 downregulates postsynaptic GABAA receptors at the hippocampal inhibitory synapse. Okada, M., Corfas, G. Hippocampus. (2004)
- Axonal neuregulin signals cells of the oligodendrocyte lineage through activation of HER4 and Schwann cells through HER2 and HER3. Vartanian, T., Goodearl, A., Viehöver, A., Fischbach, G. J. Cell Biol. (1997)
- Alternative neural crest cell fates are instructively promoted by TGFbeta superfamily members. Shah, N.M., Groves, A.K., Anderson, D.J. Cell (1996)
- Cdk5 is involved in neuregulin-induced AChR expression at the neuromuscular junction. Fu, A.K., Fu, W.Y., Cheung, J., Tsim, K.W., Ip, F.C., Wang, J.H., Ip, N.Y. Nat. Neurosci. (2001)
- Evidence that axon-derived neuregulin promotes oligodendrocyte survival in the developing rat optic nerve. Fernandez, P.A., Tang, D.G., Cheng, L., Prochiantz, A., Mudge, A.W., Raff, M.C. Neuron (2000)
- GGF/neuregulin is a neuronal signal that promotes the proliferation and survival and inhibits the differentiation of oligodendrocyte progenitors. Canoll, P.D., Musacchio, J.M., Hardy, R., Reynolds, R., Marchionni, M.A., Salzer, J.L. Neuron (1996)
- Glial growth factor/neuregulin inhibits Schwann cell myelination and induces demyelination. Zanazzi, G., Einheber, S., Westreich, R., Hannocks, M.J., Bedell-Hogan, D., Marchionni, M.A., Salzer, J.L. J. Cell Biol. (2001)
- Activity-dependent regulation of Neu differentiation factor/neuregulin expression in rat brain. Eilam, R., Pinkas-Kramarski, R., Ratzkin, B.J., Segal, M., Yarden, Y. Proc. Natl. Acad. Sci. U.S.A. (1998)
- Neu differentiation factor stimulates phosphorylation and activation of the Sp1 transcription factor. Alroy, I., Soussan, L., Seger, R., Yarden, Y. Mol. Cell. Biol. (1999)
- Neuregulin signaling on glucose transport in muscle cells. Cantó, C., Suárez, E., Lizcano, J.M., Griñó, E., Shepherd, P.R., Fryer, L.G., Carling, D., Bertran, J., Palacín, M., Zorzano, A., Gumà, A. J. Biol. Chem. (2004)
- Release of the neuregulin functional polypeptide requires its cytoplasmic tail. Liu, X., Hwang, H., Cao, L., Wen, D., Liu, N., Graham, R.M., Zhou, M. J. Biol. Chem. (1998)
- beta-Neuregulin and autocrine mediated survival of Schwann cells requires activity of Ets family transcription factors. Parkinson, D.B., Langner, K., Namini, S.S., Jessen, K.R., Mirsky, R. Mol. Cell. Neurosci. (2002)
- Identification of a neuregulin and protein-tyrosine phosphatase response element in the nicotinic acetylcholine receptor epsilon subunit gene: regulatory role of an Rts transcription factor. Sapru, M.K., Florance, S.K., Kirk, C., Goldman, D. Proc. Natl. Acad. Sci. U.S.A. (1998)
- The neuron-glia signal beta neuregulin induces sustained CREB phosphorylation on Ser-133 in cultured rat Schwann cells. Tabernero, A., Stewart, H.J., Jessen, K.R., Mirsky, R. Mol. Cell. Neurosci. (1998)
- Neuregulin stimulates myogenic differentiation in an autocrine manner. Kim, D., Chi, S., Lee, K.H., Rhee, S., Kwon, Y.K., Chung, C.H., Kwon, H., Kang, M.S. J. Biol. Chem. (1999)
- Regulation of NMDA receptors by neuregulin signaling in prefrontal cortex. Gu, Z., Jiang, Q., Fu, A.K., Ip, N.Y., Yan, Z. J. Neurosci. (2005)
- Induction of Cdk5 activity in rat skeletal muscle after nerve injury. Fu, W.Y., Fu, A.K., Lok, K.C., Ip, F.C., Ip, N.Y. Neuroreport (2002)
- Reciprocal signaling between spiral ganglion neurons and Schwann cells involves neuregulin and neurotrophins. Hansen, M.R., Vijapurkar, U., Koland, J.G., Green, S.H. Hear. Res. (2001)
- Expression of alpha2a-2b neuregulin-1 is associated with early peripheral nerve repair along muscle-enriched tubes. Nicolino, S., Raimondo, S., Tos, P., Battiston, B., Fornaro, M., Geuna, S., Perroteau, I. Neuroreport (2003)
- A real-time quantitative PCR comparative study between rat optic and sciatic nerves: determination of neuregulin-1 mRNA levels. Martínez, J.C., Malavé, C., Bosch, I., Castillo, C., Núñez, J., Villegas, G.M., Villegas, R. Brain Res. Mol. Brain Res. (2004)
- Neuregulin receptors, erbB3 and erbB4, are localized at neuromuscular synapses. Zhu, X., Lai, C., Thomas, S., Burden, S.J. EMBO J. (1995)