The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

Links

 

Gene Review

PRKCDBP  -  protein kinase C, delta binding protein

Homo sapiens

Synonyms: CAVIN3, Cavin-3, HSRBC, MGC20400, Protein kinase C delta-binding protein, ...
 
 
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.
 

Disease relevance of PRKCDBP

 

High impact information on PRKCDBP

  • A cDNA clone encoding human SRBC [serum deprivation response factor (sdr)-related gene product that binds to c-kinase] was isolated in a yeast two-hybrid screening, with amino acids 1-304 of BRCA1 as the probe [1].
  • Our results suggest that epigenetic or mutational inactivation of hSRBC may contribute to the pathogenesis of several types of human cancers, marking hSRBC as a candidate tumor suppressor gene [1].
  • In COS1 cells, the phosphorylation of over-expressed SRBC is stimulated by 12-O-tetradecanoylphorbol-13-acetate and further enhanced by the over-expression of PKCdelta [2].
  • Furthermore, SRBC mRNA is induced during retinoic acid-induced differentiation of P19 cells [2].
  • The mRNA for SRBC is detected in a wide variety of cultured cell lines and tissues and is strongly induced by serum starvation [2].
 

Chemical compound and disease context of PRKCDBP

 

Biological context of PRKCDBP

  • These results suggest that SRBC serves as a substrate and/or receptor for PKC and might be involved in the control of cell growth mediated by PKC [2].
  • Both hSRBC immunostaining and methylation results did not correlate with clinicopathological characteristics of these patients [3].
  • Use of SRBC antibody responses for immunotoxicity testing [4].
 

Anatomical context of PRKCDBP

  • To determine the methylation status of hSRBC in a large collection of primary lung cancer samples, corresponding nonmalignant lung tissues and lung cancer cell lines (N=52), we designed primers for a methylation-specific PCR assay [3].
  • Data suggest that the primary antibody response to SRBC may be one of the most sensitive endpoints available to assess chemical-induced alterations to the immune system [4].
  • The increase observed in the percentage of erythrophagocytosis with SeRBC and sensitised RBC (SRBC) confirmed the involvement of autologous IgG in the selective removal of erythrocytes [5].

References

  1. Inactivation of human SRBC, located within the 11p15.5-p15.4 tumor suppressor region, in breast and lung cancers. Xu, X.L., Wu, L.C., Du, F., Davis, A., Peyton, M., Tomizawa, Y., Maitra, A., Tomlinson, G., Gazdar, A.F., Weissman, B.E., Bowcock, A.M., Baer, R., Minna, J.D. Cancer Res. (2001) [Pubmed]
  2. A protein kinase Cdelta-binding protein SRBC whose expression is induced by serum starvation. Izumi, Y., Hirai, S., Tamai, Y., Fujise-Matsuoka, A., Nishimura, Y., Ohno, S. J. Biol. Chem. (1997) [Pubmed]
  3. Expression of the candidate tumor suppressor gene hSRBC is frequently lost in primary lung cancers with and without DNA methylation. Zöchbauer-Müller, S., Fong, K.M., Geradts, J., Xu, X., Seidl, S., End-Pfützenreuter, A., Lang, G., Heller, G., Zielinski, C.C., Gazdar, A.F., Minna, J.D. Oncogene (2005) [Pubmed]
  4. Use of SRBC antibody responses for immunotoxicity testing. Ladics, G.S. Methods (2007) [Pubmed]
  5. Effect of membrane-bound IgG and desialysation in the interaction of monocytes with senescent erythrocytes. Ensinck, A., Biondi, C.S., Marini, A., Garc??a Borr??s, S., Racca, L.L., Cotorruelo, C.M., Racca, A.L. Clin. Exp. Med. (2006) [Pubmed]
 
WikiGenes - Universities