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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
Gene Review: 

CHRM3  -  cholinergic receptor, muscarinic 3

Homo sapiens

Synonyms: Muscarinic acetylcholine receptor M3
 
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Disease relevance of CHRM3

  • Our conclusion is that the presence of muscarinic acetylcholine receptor M3 by immunostaining distinguishes normal glandular epithelium and low-grade carcinomas from poorly differentiated tumors, which suggests that its demonstration in vivo could be a useful tool in distinguishing grade of tumor clinically [1].
 

High impact information on CHRM3

  • CHRM3 Gene Variation Is Associated With Decreased Acute Insulin Secretion and Increased Risk for Early-Onset Type 2 Diabetes in Pima Indians [2].
  • The muscarinic acetylcholine receptor subtype M3 (CHRM3) gene is expressed in islet beta-cells and has a role in stimulating insulin secretion; therefore, CHRM3 was analyzed as a candidate gene for type 2 diabetes in Pima Indians [2].

References

  1. Muscarinic M3 acetylcholine receptor immunostaining in paraffin-embedded normal and neoplastic prostatic gland tissue. Blanco, M., Robinson, M.J. Annals of diagnostic pathology. (2004)
  2. CHRM3 Gene Variation Is Associated With Decreased Acute Insulin Secretion and Increased Risk for Early-Onset Type 2 Diabetes in Pima Indians. Guo, Y., Traurig, M., Ma, L., Kobes, S., Harper, I., Infante, A.M., Bogardus, C., Baier, L.J., Prochazka, M. Diabetes (2006)
 

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Links

  • Homologues
  • NCBI Gene
  • NCBI SNP
  • iHOP resource
  • OMIM
  • SNPedia
  • UniProt
  • Ensembl
  • HGNC

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