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Gene Review: 

ADCY8  -  adenylate cyclase 8 (brain)

Homo sapiens

Synonyms: AC8, ADCY3, ATP pyrophosphate-lyase 8, Adenylate cyclase type 8, Adenylate cyclase type VIII, ...
 
 
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High impact information on ADCY8

  • Biologically, plausible candidate genes in this region include thyroglobulin, KCNQ3 coding for a voltage-gated potassium channel and the gene for brain adenyl-cyclase (ADCY8) [1].
  • Given that human HBAC maps to the short arm of chromosome 16, the mapping of rabbit HBAC to 6q12 confirms the assignment of homology between OCU6q and HSA16p based on similarities of chromosomal banding patterns [2].
  • The rabbit (Oryctolagus cuniculus) alpha-like globin gene cluster (HBAC) contains several block duplications of zeta-, alpha and theta-globin genes [2].

References

  1. Linkage of bipolar affective disorder on chromosome 8q24: follow-up and parametric analysis. Avramopoulos, D., Willour, V.L., Zandi, P.P., Huo, Y., MacKinnon, D.F., Potash, J.B., DePaulo, J.R., McInnis, M.G. Mol. Psychiatry (2004) [Pubmed]
  2. Localization of the alpha-like globin gene cluster to region q12 of rabbit chromosome 6 by in situ hybridization. Xu, J., Hardison, R.C. Genomics (1991) [Pubmed]
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