Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Gene: Sardh - sarcosine dehydrogenase

Rattus norvegicus

Synonyms: Sarcosine dehydrogenase, mitochondrial precursor, SarDH

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Cook, R.J., Wittwer, A.J., Cook, R.J., Foster, M.W., Dombrowski, J.J.

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High impact information on Sardh

S-Nitrosylation of SarDH by NO is best rationalized by a novel mechanism involving the covalently bound flavin of the enzyme [1].
The amino acid sequences of the flavin-peptides of dimethylglycine dehydrogenase and sarcosine dehydrogenase from rat liver mitochondria [2].
The flavoenzymes dimethylglycine dehydrogenase (EC 1.5.99.2) and sarcosine dehydrogenase (EC 1.5.99.1) contain covalently bound FAD linked via the 8 alpha-position of the isoalloxazine ring to the imidazole N(3) of a histidine residue (Cook, R. J., Misono, K. S., and Wagner, C. (1984) J. Biol. Chem. 259, 12475-12480) [2].
Identification of the folate-binding proteins of rat liver mitochondria as dimethylglycine dehydrogenase and sarcosine dehydrogenase. Purification and folate-binding characteristics [3].
Sarcosine dehydrogenase and the vital economy of hepatic mitochondria utilizing riboflavin homologs [4].

Associations of Sardh with chemical compounds

The sequence determined for the flavin-peptide from sarcosine dehydrogenase contained 14 amino acid residues Leu-Thr-Ser-Gly-Thr-Thr-Trp-His(flavin)-Thr-Ala-Gly-Leu-Gly-Arg [2].
Dimethylglycine dehydrogenase (EC 1.5.99.2) and sarcosine dehydrogenase (EC 1.5.99.1) are the folate binding proteins of rat liver mitochondria [5].

References

New insights into protein S-nitrosylation. Mitochondria as a model system. Foster, M.W., Stamler, J.S. J. Biol. Chem. (2004)
The amino acid sequences of the flavin-peptides of dimethylglycine dehydrogenase and sarcosine dehydrogenase from rat liver mitochondria. Cook, R.J., Misono, K.S., Wagner, C. J. Biol. Chem. (1985)
Identification of the folate-binding proteins of rat liver mitochondria as dimethylglycine dehydrogenase and sarcosine dehydrogenase. Purification and folate-binding characteristics. Wittwer, A.J., Wagner, C. J. Biol. Chem. (1981)
Sarcosine dehydrogenase and the vital economy of hepatic mitochondria utilizing riboflavin homologs. Dombrowski, J.J., Lambooy, J.P. Int. J. Biochem. (1981)
Identification of the covalently bound flavin of dimethylglycine dehydrogenase and sarcosine dehydrogenase from rat liver mitochondria. Cook, R.J., Misono, K.S., Wagner, C. J. Biol. Chem. (1984)

Gene: Sardh - sarcosine dehydrogenase

Rattus norvegicus

High impact information on Sardh

Associations of Sardh with chemical compounds

References

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