Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Gene: Foxp2 - forkhead box P2

Mus musculus

Synonyms: 2810043D05Rik, AI449000, CAG-16, D0Kist7, Forkhead box protein P2

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Ferland, R.J., White, S.A., Yang, H., Shu, W., Lu, M.M.

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Disease relevance of Foxp2

In 2001, a point mutation in the forkhead box P2 (FOXP2) coding sequence was identified as the basis of an inherited speech and language disorder suffered by members of the family known as "KE." This mini-symposium review focuses on recent findings and research-in-progress, primarily from five laboratories [1].

High impact information on Foxp2

Cerebellar abnormalities were observed in mice with disruptions in Foxp2, with Purkinje cells particularly affected [2].
These embryos also exhibited increased Foxp2 gene expression, suggesting a disruption in late alveolar epithelial differentiation [3].
Since Foxp2 appears to be important in language, we wanted to explore the expression of this gene and a homologous gene, Foxp1, in the developing brain [4].
Expression of Foxp2 was also observed in the cerebral cortex (layer 6), cerebellum (Purkinje neurons), and thalamus [4].
Foxp2 and Foxp1 were most highly expressed in the developing and mature basal ganglia [4].

Other interactions of Foxp2

At embryonic day 12.5, Foxp1 and Foxp2 are expressed in both the mucosal and epithelial layers of the intestine [5].

Analytical, diagnostic and therapeutic context of Foxp2

In the present study, we investigated the time course and localization of Foxp2 and Foxp1 mRNA and protein expression in the developing and adult mouse using in situ hybridization and immunohistochemistry [4].

References

Singing mice, songbirds, and more: models for FOXP2 function and dysfunction in human speech and language. White, S.A., Fisher, S.E., Geschwind, D.H., Scharff, C., Holy, T.E. J. Neurosci. (2006)
Altered ultrasonic vocalization in mice with a disruption in the Foxp2 gene. Shu, W., Cho, J.Y., Jiang, Y., Zhang, M., Weisz, D., Elder, G.A., Schmeidler, J., De Gasperi, R., Sosa, M.A., Rabidou, D., Santucci, A.C., Perl, D., Morrisey, E., Buxbaum, J.D. Proc. Natl. Acad. Sci. U.S.A. (2005)
GATA6 regulates differentiation of distal lung epithelium. Yang, H., Lu, M.M., Zhang, L., Whitsett, J.A., Morrisey, E.E. Development (2002)
Characterization of Foxp2 and Foxp1 mRNA and protein in the developing and mature brain. Ferland, R.J., Cherry, T.J., Preware, P.O., Morrisey, E.E., Walsh, C.A. J. Comp. Neurol. (2003)
Foxp4: a novel member of the Foxp subfamily of winged-helix genes co-expressed with Foxp1 and Foxp2 in pulmonary and gut tissues. Lu, M.M., Li, S., Yang, H., Morrisey, E.E. Gene Expr. Patterns (2002)