Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Gene: Sfrs10 - splicing factor, arginine/serine-rich 10...

Rattus norvegicus

Synonyms: Arginine/serine-rich splicing factor 10, HTRA2-beta, RA301, Splicing factor, arginine/serine-rich 10, Tra2b, Transformer-2-beta, Transformer 2 protein homolog

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Tsukamoto, Y., Matsuo, N., Imai, Y.

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Disease relevance of Sfrs10

Cloning of a novel RNA binding polypeptide (RA301) induced by hypoxia/reoxygenation [1].
To elucidate the role of astrocytes in the stress response of the central nervous system to ischemia, early gene expression was examined in rat cultured astrocytes after the exposure to hypoxia/reoxygenation, and we have previously cloned a novel RNA binding protein, RA301, from the reoxygenated astrocytes [2].

High impact information on Sfrs10

RA301/Tra2beta, a sequence-specific RNA-binding protein, was first cloned as a stress molecule in re-oxygenated astrocytes [3].
Consistent with a link between RA301/Tra2beta and cell proliferation, platelet-derived growth factor also induced expression of RA301/Tra2beta in cultured VSMCS: These data suggest a possible role for RA301/Tra2beta in the regulation of VSMC proliferation, especially in the setting of hypoxia/re-oxygenation-induced cell stress [3].
Balloon injury to the rat carotid artery induced RA301/Tra2beta transcripts followed by expression of the antigen, which was detected in medial and neointimal vascular smooth muscle cells (VSMCs) [3].
In human vascular tissues, we have found enhanced RA301/Tra2beta expression in coronary artery with intimal thickening, and atherosclerotic aorta [3].
Expression of a novel RNA-splicing factor, RA301/Tra2beta, in vascular lesions and its role in smooth muscle cell proliferation [3].

Biological context of Sfrs10

Using a differential display method, a novel putative RNA binding protein, RA301, was cloned from reoxygenated astrocytes [1].

Associations of Sfrs10 with chemical compounds

Induction of RA301 mRNA was mediated, in large part, by endogenously generated reactive oxygen species, as shown by diphenyl iodonium, an inhibitor of neutrophil-type nicotinamide adenine dinucleotide phosphate oxidase which blocks oxygen-free radical formation by astrocytes [1].

Other interactions of Sfrs10

Similarly, increased expression of RA301 in supporting a neurotrophic function of astrocytes was suggested by inhibition of interleukin-6 elaboration, a neuroprotective cytokine, in the presence of antisense oligonucleotide for RA301 [1].

References

Cloning of a novel RNA binding polypeptide (RA301) induced by hypoxia/reoxygenation. Matsuo, N., Ogawa, S., Imai, Y., Takagi, T., Tohyama, M., Stern, D., Wanaka, A. J. Biol. Chem. (1995)
Cloning of a gene, YT521, for a novel RNA splicing-related protein induced by hypoxia/reoxygenation. Imai, Y., Matsuo, N., Ogawa, S., Tohyama, M., Takagi, T. Brain Res. Mol. Brain Res. (1998)
Expression of a novel RNA-splicing factor, RA301/Tra2beta, in vascular lesions and its role in smooth muscle cell proliferation. Tsukamoto, Y., Matsuo, N., Ozawa, K., Hori, O., Higashi, T., Nishizaki, J., Tohnai, N., Nagata, I., Kawano, K., Yutani, C., Hirota, S., Kitamura, Y., Stern, D.M., Ogawa, S. Am. J. Pathol. (2001)