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Slc15a1  -  solute carrier family 15 (oligopeptide...

Rattus norvegicus

Synonyms: Intestinal H(+)/peptide cotransporter, Oligopeptide transporter, small intestine isoform, Pept1, Peptide transporter 1, Proton-coupled dipeptide cotransporter, ...
 
 
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High impact information on Slc15a1

  • Transport characteristics of a novel peptide transporter 1 substrate, antihypotensive drug midodrine, and its amino acid derivatives [1].
  • The intestinal H+-coupled peptide transporter 1 (PEPT1) transports various peptide-like drugs and has been used as a target molecule for improving the intestinal absorption of poorly absorbed drugs through amino acid modifications [1].
  • Lastly, studies of the specificity of the above effect showed that uncontrolled diabetes similarly affected the protein and gene expressions of Pept-1 located in the kidney [2].
  • Uncontrolled diabetes for 96 h increased the activity of Pept-1 in the brush-border membrane of intestinal mucosa [2].
  • Abnormal Expression of the Peptide Transporter PepT1 in the Colon of Massive Bowel Resection Rat: A Potential Route for Colonic Mucosa Damage by Transport of fMLP [3].
 

Biological context of Slc15a1

  • Interrelationships between energy homeostasis and regulation of cardiovascular functions have been suggested by previous observations [Am. J. Physiol. 278 (2000) R692; Regul. Pept. 104 (2002) 75; Am. J. Physiol. 277 (1999) R1780] [4].
 

Anatomical context of Slc15a1

 

Associations of Slc15a1 with chemical compounds

 

Other interactions of Slc15a1

 

Analytical, diagnostic and therapeutic context of Slc15a1

  • Western blot analysis of lysosomal membrane proteins with Pept-1 (an oligopeptide transporter) antibody as the probe showed the presence of an immunoreactive protein [11].

References

  1. Transport characteristics of a novel peptide transporter 1 substrate, antihypotensive drug midodrine, and its amino acid derivatives. Tsuda, M., Terada, T., Irie, M., Katsura, T., Niida, A., Tomita, K., Fujii, N., Inui, K. J. Pharmacol. Exp. Ther. (2006) [Pubmed]
  2. Regulation of oligopeptide transporter (Pept-1) in experimental diabetes. Gangopadhyay, A., Thamotharan, M., Adibi, S.A. Am. J. Physiol. Gastrointest. Liver Physiol. (2002) [Pubmed]
  3. Abnormal Expression of the Peptide Transporter PepT1 in the Colon of Massive Bowel Resection Rat: A Potential Route for Colonic Mucosa Damage by Transport of fMLP. Shi, B., Song, D., Xue, H., Li, J., Li, N., Li, J. Dig. Dis. Sci. (2006) [Pubmed]
  4. Central pressor effects of CART peptides in anesthetized rats. Hwang, L.L., Chen, C.T., Li, T.L., Chiu, C.Z., Chi, S.F. Neuropeptides (2004) [Pubmed]
  5. Peptide transporter in the rat small intestine: ultrastructural localization and the effect of starvation and administration of amino acids. Ogihara, H., Suzuki, T., Nagamachi, Y., Inui, K., Takata, K. Histochem. J. (1999) [Pubmed]
  6. Functional and molecular expression of intestinal oligopeptide transporter (Pept-1) after a brief fast. Thamotharan, M., Bawani, S.Z., Zhou, X., Adibi, S.A. Metab. Clin. Exp. (1999) [Pubmed]
  7. Angiopeptin, a somatostatin-14 analogue, decreases adhesiveness of rat leukocytes to unstimulated and IL-1 beta-activated rat heart endothelial cells. Leszczynski, D., Dunsky, K., Josephs, M.D., Zhao, Y., Foegh, M.L. Life Sci. (1995) [Pubmed]
  8. Effect of lipopolysaccharide on peptide transporter 1 expression in rat small intestine and its attenuation by dexamethasone. Shu, H.J., Takeda, H., Shinzawa, H., Takahashi, T., Kawata, S. Digestion (2002) [Pubmed]
  9. Role of disulfide bridges in the folding, structure and biological activity of omega-conotoxin GVIA. Flinn, J.P., Pallaghy, P.K., Lew, M.J., Murphy, R., Angus, J.A., Norton, R.S. Biochim. Biophys. Acta (1999) [Pubmed]
  10. Expression of peptide transporter following intestinal transplantation in the rat. Motohashi, H., Masuda, S., Katsura, T., Saito, H., Sakamoto, S., Uemoto, S., Tanaka, K., Inui, K.I. J. Surg. Res. (2001) [Pubmed]
  11. Characterization of an oligopeptide transporter in renal lysosomes. Zhou, X., Thamotharan, M., Gangopadhyay, A., Serdikoff, C., Adibi, S.A. Biochim. Biophys. Acta (2000) [Pubmed]
 
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