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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
Gene: Ank3     ankyrin 3, epithelialMus musculus
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Disease relevance of Ank3

 

High impact information on Ank3

  • We have recently cloned and characterized ankyrin-3 (also called ankyrin(G)), a new ankyrin that is widely distributed, especially in epithelial tissues, muscle, and neuronal axons (Peters, L.L., K.M. John, F.M. Lu, E.M. Eicher, A. Higgins, M. Yialamas, L.C. Turtzo, A.J. Otsuka, and S.E. Lux. 1995. J. Cell Biol. 130: 313-330) [2].
  • Isoforms of ankyrin-3 that lack the NH2-terminal repeats associate with mouse macrophage lysosomes [2].
  • Second, the ankyrin-3-positive vesicles contain lysosomal-associated membrane glycoprotein (LAMP-1), a recognized lysosomal marker [2].
  • Also, epitope-tagged mouse macrophage ankyrin-3, transiently expressed in COS cells, associates with intracellular, not plasma, membranes [2].
  • Here we show that in mouse macrophages, ankyrin-3 is expressed exclusively as two small isoforms (120 and 100 kD) that lack the NH2-terminal repeats [2].
 

Biological context of Ank3

  • The jcpk intercross allowed the orientation of the Ank3 gene relative to the centromere to be determined [1].
 

Anatomical context of Ank3

 

Other interactions of Ank3

  • The Ank3 gene maps to mouse Chromosome 10, approximately 36 cM from the centromere, a locus distinct from Ank1 and Ank2 [3].
  • In immunoprecipitates, the alpha1 and alpha2 subunits of the Na,K-ATPase as well as ankyrin 3 associate with beta-spectrin/alpha- fodrin heteromers and with a pool of beta-spectrin at the sarcolemma that does not contain alpha-fodrin [6].
 

Analytical, diagnostic and therapeutic context of Ank3

References

  1. Fine genetic map of mouse chromosome 10 around the polycystic kidney disease gene, jcpk, and ankyrin 3. Bryda, E.C., Ling, H., Rathbun, D.E., Burmeister, M., Flaherty, L. Genomics (1996)
  2. Isoforms of ankyrin-3 that lack the NH2-terminal repeats associate with mouse macrophage lysosomes. Hoock, T.C., Peters, L.L., Lux, S.E. J. Cell Biol. (1997)
  3. Ank3 (epithelial ankyrin), a widely distributed new member of the ankyrin gene family and the major ankyrin in kidney, is expressed in alternatively spliced forms, including forms that lack the repeat domain. Peters, L.L., John, K.M., Lu, F.M., Eicher, E.M., Higgins, A., Yialamas, M., Turtzo, L.C., Otsuka, A.J., Lux, S.E. J. Cell Biol. (1995)
  4. Distribution of epithelial ankyrin (Ank3) spliceoforms in renal proximal and distal tubules. Doctor, R.B., Chen, J., Peters, L.L., Lux, S.E., Mandel, L.J. Am. J. Physiol. (1998)
  5. Biogenesis of polarized epithelial cells during kidney development in situ: roles of E-cadherin-mediated cell-cell adhesion and membrane cytoskeleton organization. Piepenhagen, P.A., Nelson, W.J. Mol. Biol. Cell (1998)
  6. Na,K-ATPase in skeletal muscle: two populations of beta-spectrin control localization in the sarcolemma but not partitioning between the sarcolemma and the transverse tubules. Williams, M.W., Resneck, W.G., Kaysser, T., Ursitti, J.A., Birkenmeier, C.S., Barker, J.E., Bloch, R.J. J. Cell. Sci. (2001)