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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
Gene Review: 

Sept2  -  septin 2

Rattus norvegicus

Synonyms: Nedd5, Septin-2, Vascular endothelial cell specific protein 11, Vesp11
 
 
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High impact information on Sept2

  • Furthermore, MSF isoforms localize primarily with tubulin at the central spindle during mitosis, whereas Nedd5 is mainly associated with actin [1].
  • Interestingly, the over-expression of a GTPase-defective Nedd5 mutant promotes aberrant neurite sprouting in PC12 cells [2].
  • These results demonstrate that Nedd5 and other septin proteins are associated with both the exocyst complex and microtubules and uncover a putative role for the Nedd5 GTPase activity in neurite outgrowth [2].
  • The septin protein Nedd5 associates with both the exocyst complex and microtubules and disruption of its GTPase activity promotes aberrant neurite sprouting in PC12 cells [2].
  • The endogenous Nedd5 is enriched at the perinuclear region in undifferentiated PC12 cells and radiates outward, from the perinuclear region toward the growth cone, upon NGF-induced PC12 neuronal differentiation [2].
 

Anatomical context of Sept2

  • Taken together, these findings suggest that Nedd5 may be required for polarized neurite outgrowth, perhaps, by facilitating the exocyst complex function during neuronal differentiation [2].

References

  1. The mammalian septin MSF localizes with microtubules and is required for completion of cytokinesis. Surka, M.C., Tsang, C.W., Trimble, W.S. Mol. Biol. Cell (2002) [Pubmed]
  2. The septin protein Nedd5 associates with both the exocyst complex and microtubules and disruption of its GTPase activity promotes aberrant neurite sprouting in PC12 cells. Vega, I.E., Hsu, S.C. Neuroreport (2003) [Pubmed]
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