Gene Review:
Serpinc1 - serine (or cysteine) peptidase inhibitor,...
Mus musculus
Synonyms:
AI114908, ATIII, Antithrombin-III, At-3, At3, ...
- Complete antithrombin deficiency in mice results in embryonic lethality. Ishiguro, K., Kojima, T., Kadomatsu, K., Nakayama, Y., Takagi, A., Suzuki, M., Takeda, N., Ito, M., Yamamoto, K., Matsushita, T., Kusugami, K., Muramatsu, T., Saito, H. J. Clin. Invest. (2000)
- Impact of antithrombin deficiency in thrombogenesis: lipopolysaccharide and stress-induced thrombus formation in heterozygous antithrombin-deficient mice. Yanada, M., Kojima, T., Ishiguro, K., Nakayama, Y., Yamamoto, K., Matsushita, T., Kadomatsu, K., Nishimura, M., Muramatsu, T., Saito, H. Blood (2002)
- Effects of recombinant human soluble thrombomodulin (rhs-TM) on a rat model of disseminated intravascular coagulation with decreased levels of plasma antithrombin III. Aoki, Y., Ohishi, R., Takei, R., Matsuzaki, O., Mohri, M., Saitoh, K., Gomi, K., Sugihara, T., Kiyota, T., Yamamoto, S. Thromb. Haemost. (1994)
- Antithrombin reduces reperfusion-induced hepatic metastasis of colon cancer cells. Kurata, M., Okajima, K., Kawamoto, T., Uchiba, M., Ohkohchi, N. World J. Gastroenterol. (2006)
- Generation of C5a in the absence of C3: a new complement activation pathway. Huber-Lang, M., Sarma, J.V., Zetoune, F.S., Rittirsch, D., Neff, T.A., McGuire, S.R., Lambris, J.D., Warner, R.L., Flierl, M.A., Hoesel, L.M., Gebhard, F., Younger, J.G., Drouin, S.M., Wetsel, R.A., Ward, P.A. Nat. Med. (2006)
- Selectin-mucin interactions as a probable molecular explanation for the association of Trousseau syndrome with mucinous adenocarcinomas. Wahrenbrock, M., Borsig, L., Le, D., Varki, N., Varki, A. J. Clin. Invest. (2003)
- Life-threatening thrombosis in mice with targeted Arg48-to-Cys mutation of the heparin-binding domain of antithrombin. Dewerchin, M., Hérault, J.P., Wallays, G., Petitou, M., Schaeffer, P., Millet, L., Weitz, J.I., Moons, L., Collen, D., Carmeliet, P., Herbert, J.M. Circ. Res. (2003)
- Heparan sulfate 3-O-sulfotransferase isoform 5 generates both an antithrombin-binding site and an entry receptor for herpes simplex virus, type 1. Xia, G., Chen, J., Tiwari, V., Ju, W., Li, J.P., Malmstrom, A., Shukla, D., Liu, J. J. Biol. Chem. (2002)
- Antiphospholipid antibodies: origin, specificity, and mechanism of action. Brey, R.L., Coull, B.M. Stroke (1992)
- Coagulation disorders in experimentally induced acute mouse malaria. Reiner, G., Clemens, R., Bock, H.L., Enders, B. Acta Trop. (1991)
- Low molecular weight protamine: a potential nontoxic heparin antagonist. Byun, Y., Singh, V.K., Yang, V.C. Thromb. Res. (1999)
- Mapping of Abll within a conserved linkage group on distal mouse chromosome 1 syntenic with human chromosome 1 using an interspecific cross. Seldin, M.F., Kruh, G.D. Genomics (1989)
- Rapid and efficient construction of yeast artificial chromosome contigs in the mouse genome with interspersed repetitive sequence PCR (IRS-PCR): generation of a 5-cM, > 5 megabase contig on mouse chromosome 1. Hunter, K.W., Ontiveros, S.D., Watson, M.L., Stanton, V.P., Gutierrez, P., Bhat, D., Rochelle, J., Graw, S., Ton, C., Schalling, M. Mamm. Genome (1994)
- Antiangiogenic effects of latent antithrombin through perturbed cell-matrix interactions and apoptosis of endothelial cells. Larsson, H., Sjöblom, T., Dixelius, J., Ostman, A., Ylinenjärvi, K., Björk, I., Claesson-Welsh, L. Cancer Res. (2000)
- L-asparaginase-induced antithrombin type I deficiency: implications for conformational diseases. Hernández-Espinosa, D., Miñano, A., Martínez, C., Pérez-Ceballos, E., Heras, I., Fuster, J.L., Vicente, V., Corral, J. Am. J. Pathol. (2006)
- Structure and affinity for antithrombin of heparan sulfate chains derived from basement membrane proteoglycans. Pejler, G., Bäckström, G., Lindahl, U., Paulsson, M., Dziadek, M., Fujiwara, S., Timpl, R. J. Biol. Chem. (1987)
- Biosynthesis of heparin. Availability of glucosaminyl 3-O-sulfation sites. Kusche, M., Torri, G., Casu, B., Lindahl, U. J. Biol. Chem. (1990)
- Inhibition of the platelet-aggregating activity of two human adenocarcinomas of the colon and an anaplastic murine tumor with a specific thrombin inhibitor, dansylarginine N-(3-ethyl-1,5-pentanediyl)amide. Pearlstein, E., Ambrogio, C., Gasic, G., Karpatkin, S. Cancer Res. (1981)
- Cell-free synthesis of anticoagulant heparan sulfate reveals a limiting converting activity that modifies an excess precursor pool. Shworak, N.W., Fritze, L.M., Liu, J., Butler, L.D., Rosenberg, R.D. J. Biol. Chem. (1996)
- Biosynthesis of heparin. Effects of n-butyrate on cultured mast cells. Jacobsson, K.G., Riesenfeld, J., Lindahl, U. J. Biol. Chem. (1985)
- Thrombin stimulates syndecan-1 promotor activity and expression of a form of syndecan-1 that binds antithrombin III in vascular smooth muscle cells. Cizmeci-Smith, G., Carey, D.J. Arterioscler. Thromb. Vasc. Biol. (1997)
- Regulation of mouse T cell associated serine proteinase-1 (MTSP-1) by proteinase inhibitors and sulfated polysaccharides. Simon, M.M., Tran, T., Fruth, U., Gurwitz, D., Kramer, M.D. Biol. Chem. Hoppe-Seyler (1990)
- Age-related changes in blood coagulation and fibrinolysis in mice fed on a high-cholesterol diet. Okazaki, M., Morio, Y., Iwai, S., Miyamoto, K., Sakamoto, H., Imai, K., Oguchi, K. Exp. Anim. (1998)
- A retinoic acid-inducible mRNA from F9 teratocarcinoma cells encodes a novel protease inhibitor homologue. Wang, S.Y., Gudas, L.J. J. Biol. Chem. (1990)
- T cell-mediated neuroprotection involves antithrombin activity. Friedmann, I., Hauben, E., Yoles, E., Kardash, L., Schwartz, M. J. Neuroimmunol. (2001)
- Relationship between anticoagulant activities and polyanionic properties of rabbit thrombomodulin. Bourin, M.C., Ohlin, A.K., Lane, D.A., Stenflo, J., Lindahl, U. J. Biol. Chem. (1988)
- Thrombin induces nitric-oxide synthase via Galpha12/13-coupled protein kinase C-dependent I-kappaBalpha phosphorylation and JNK-mediated I-kappaBalpha degradation. Kang, K.W., Choi, S.Y., Cho, M.K., Lee, C.H., Kim, S.G. J. Biol. Chem. (2003)
- Anticoagulant and anti-inflammatory effects after peritoneal lavage with antithrombin in experimental polymicrobial peritonitis. VAN Veen, S.Q., Cheung, C.W., Meijers, J.C., VAN Gulik, T.M., Boermeester, M.A. J. Thromb. Haemost. (2006)
- Disruption of nuclear vitamin D receptor gene causes enhanced thrombogenicity in mice. Aihara, K., Azuma, H., Akaike, M., Ikeda, Y., Yamashita, M., Sudo, T., Hayashi, H., Yamada, Y., Endoh, F., Fujimura, M., Yoshida, T., Yamaguchi, H., Hashizume, S., Kato, M., Yoshimura, K., Yamamoto, Y., Kato, S., Matsumoto, T. J. Biol. Chem. (2004)
- Increased thrombin inhibition in experimental autoimmune encephalomyelitis. Beilin, O., Karussis, D.M., Korczyn, A.D., Gurwitz, D., Aronovich, R., Hantai, D., Grigoriadis, N., Mizrachi-Kol, R., Chapman, J. J. Neurosci. Res. (2005)
- Membrane chromatography for rapid purification of recombinant antithrombin III and monoclonal antibodies from cell culture supernatant. Lütkemeyer, D., Bretschneider, M., Büntemeyer, H., Lehmann, J. J. Chromatogr. (1993)
- Enzymatic modification of heparan sulfate on a biochip promotes its interaction with antithrombin III. Hernaiz, M., Liu, J., Rosenberg, R.D., Linhardt, R.J. Biochem. Biophys. Res. Commun. (2000)