Gene Review:
CLU - clusterin
Homo sapiens
Synonyms:
AAG4, APO-J, APOJ, Aging-associated gene 4 protein, Apo-J, ...
- Nuclear clusterin/XIP8, an x-ray-induced Ku70-binding protein that signals cell death. Yang, C.R., Leskov, K., Hosley-Eberlein, K., Criswell, T., Pink, J.J., Kinsella, T.J., Boothman, D.A. Proc. Natl. Acad. Sci. U.S.A. (2000)
- Clusterin-mediated apoptosis is regulated by adenomatous polyposis coli and is p21 dependent but p53 independent. Chen, T., Turner, J., McCarthy, S., Scaltriti, M., Bettuzzi, S., Yeatman, T.J. Cancer Res. (2004)
- Clusterin, the human apolipoprotein and complement inhibitor, binds to complement C7, C8 beta, and the b domain of C9. Tschopp, J., Chonn, A., Hertig, S., French, L.E. J. Immunol. (1993)
- Glomerular clusterin is associated with PKC-alpha/beta regulation and good outcome of membranous glomerulonephritis in humans. Rastaldi, M.P., Candiano, G., Musante, L., Bruschi, M., Armelloni, S., Rimoldi, L., Tardanico, R., Cherchi, S.S., Ferrario, F., Montinaro, V., Haupt, R., Parodi, S., Carnevali, M.L., Allegri, L., Camussi, G., Gesualdo, L., Scolari, F., Ghiggeri, G.M. Kidney Int. (2006)
- Clusterin (CLU) and prostate cancer. Rizzi, F., Bettuzzi, S. Adv. Cancer Res. (2009)
- Clusterin (CLU) and lung cancer. Panico, F., Rizzi, F., Fabbri, L.M., Bettuzzi, S., Luppi, F. Adv. Cancer Res. (2009)
- Association of apolipoprotein J-positive beta-amyloid plaques with dystrophic neurites in Alzheimer's disease brain. Martin-Rehrmann, M.D., Hoe, H.S., Capuani, E.M., Rebeck, G.W. Neurotoxicity research. (2005)
- Alcohol biomarkers: clinical significance and biochemical basis. Lakshman, R., Tsutsumi, M., Ghosh, P., Takase, S., Anni, H., Nikolaeva, O., Israel, Y., Anton, R.F., Lesch, O.M., Helender, A., Eriksson, G., Jeppson, J.O., Marmillot , P., Rao, M.N. Alcohol. Clin. Exp. Res. (2001)
- Clusterin/apolipoprotein J is associated with cortical Lewy bodies: immunohistochemical study in cases with alpha-synucleinopathies. Sasaki, K., Doh-ura, K., Wakisaka, Y., Iwaki, T. Acta Neuropathol. (2002)
- Molecular biology of the Sertoli cell. Griswold, M.D., Morales, C., Sylvester, S.R. Oxford reviews of reproductive biology. (1988)
- Clusterin solubility and aggregation in Creutzfeldt-Jakob disease. Freixes, M., Puig, B., Rodríguez, A., Torrejón-Escribano, B., Blanco, R., Ferrer, I. Acta Neuropathol. (2004)
- Sulfated glycoprotein 2: new relationships of this multifunctional protein to neurodegeneration. May, P.C., Finch, C.E. Trends Neurosci. (1992)
- Clusterin inhibits apoptosis by interacting with activated Bax. Zhang, H., Kim, J.K., Edwards, C.A., Xu, Z., Taichman, R., Wang, C.Y. Nat. Cell Biol. (2005)
- Functional analysis of clusterin/apolipoprotein J in cellular death induced by severe genotoxic stress. Trougakos, I.P., Gonos, E.S. Ann. N. Y. Acad. Sci. (2004)
- Depletion of clusterin in renal diseases causing nephrotic syndrome. Ghiggeri, G.M., Bruschi, M., Candiano, G., Rastaldi, M.P., Scolari, F., Passerini, P., Musante, L., Pertica, N., Caridi, G., Ferrario, F., Perfumo, F., Ponticelli, C. Kidney Int. (2002)
- Clusterin expression is significantly enhanced in prostate cancer cells following androgen withdrawal therapy. July, L.V., Akbari, M., Zellweger, T., Jones, E.C., Goldenberg, S.L., Gleave, M.E. Prostate (2002)
- Current status of carbohydrate deficient transferrin, total serum sialic acid, sialic acid index of apolipoprotein J and serum beta-hexosaminidase as markers for alcohol consumption. Javors, M.A., Johnson, B.A. Addiction (2003)
- Clusterin protects the lung from leukocyte-induced injury. Heller, A.R., Fiedler, F., Braun, P., Stehr, S.N., Bödeker, H., Koch, T. Shock (2003)
- The cerebrospinal-fluid soluble form of Alzheimer's amyloid beta is complexed to SP-40,40 (apolipoprotein J), an inhibitor of the complement membrane-attack complex. Ghiso, J., Matsubara, E., Koudinov, A., Choi-Miura, N.H., Tomita, M., Wisniewski, T., Frangione, B. Biochem. J. (1993)
- Interaction of apolipoprotein J-amyloid beta-peptide complex with low density lipoprotein receptor-related protein-2/megalin. A mechanism to prevent pathological accumulation of amyloid beta-peptide. Hammad, S.M., Ranganathan, S., Loukinova, E., Twal, W.O., Argraves, W.S. J. Biol. Chem. (1997)
- Clusterin, an abundant serum factor, is a possible negative regulator of MT6-MMP/MMP-25 produced by neutrophils. Matsuda, A., Itoh, Y., Koshikawa, N., Akizawa, T., Yana, I., Seiki, M. J. Biol. Chem. (2003)
- Identification of glycoprotein 330 as an endocytic receptor for apolipoprotein J/clusterin. Kounnas, M.Z., Loukinova, E.B., Stefansson, S., Harmony, J.A., Brewer, B.H., Strickland, D.K., Argraves, W.S. J. Biol. Chem. (1995)
- Regulation of clusterin secretion and mRNA expression in astrocytes by cytokines. Zwain, I.H., Grima, J., Cheng, C.Y. Mol. Cell. Neurosci. (1994)
- Protein tyrosine phosphatase regulation of endothelial cell apoptosis and differentiation. Yang, C., Chang, J., Gorospe, M., Passaniti, A. Cell Growth Differ. (1996)
- Testicular changes during infantile 'quiescence' in the marmoset and their gonadotrophin dependence: a model for investigating susceptibility of the prepubertal human testis to cancer therapy? Kelnar, C.J., McKinnell, C., Walker, M., Morris, K.D., Wallace, W.H., Saunders, P.T., Fraser, H.M., Sharpe, R.M. Hum. Reprod. (2002)
- Chapter 2: Clusterin (CLU): From one gene and two transcripts to many proteins. Rizzi, F., Coletta, M., Bettuzzi, S. Adv. Cancer Res. (2009)
- Isolation and characterization of a novel gene CLUAP1 whose expression is frequently upregulated in colon cancer. Takahashi, M., Lin, Y.M., Nakamura, Y., Furukawa, Y. Oncogene (2004)
- 150-kDa oxygen-regulated protein (ORP150) functions as a novel molecular chaperone in MDCK cells. Bando, Y., Ogawa, S., Yamauchi, A., Kuwabara, K., Ozawa, K., Hori, O., Yanagi, H., Tamatani, M., Tohyama, M. Am. J. Physiol., Cell Physiol. (2000)
- Clusterin (complement lysis inhibitor) forms a high density lipoprotein complex with apolipoprotein A-I in human plasma. Jenne, D.E., Lowin, B., Peitsch, M.C., Böttcher, A., Schmitz, G., Tschopp, J. J. Biol. Chem. (1991)
- Distinct sites of production and deposition of the putative cell death marker clusterin in the human thymus. French, L.E., Sappino, A.P., Tschopp, J., Schifferli, J.A. J. Clin. Invest. (1992)
- Influence of lipoproteins on microglial degradation of Alzheimer's amyloid beta-protein. Cole, G.M., Ard, M.D. Microsc. Res. Tech. (2000)
- Upregulation of glial clusterin in brains of patients with AIDs. Torres-Muñoz, J.E., Redondo, M., Czeisler, C., Roberts, B., Tacoronte, N., Petito, C.K. Brain Res. (2001)
- Enhanced radiosensitivity by inhibition of the anti-apoptotic gene clusterin using antisense oligodeoxynucleotide in a human bladder cancer model. Yamanaka, K., Gleave, M., Muramaki, M., Hara, I., Miyake, H. Oncol. Rep. (2005)
- Repression of IR-inducible clusterin expression by the p53 tumor suppressor protein. Criswell, T., Klokov, D., Beman, M., Lavik, J.P., Boothman, D.A. Cancer Biol. Ther. (2003)
- Human seminal clusterin (SP-40,40). Isolation and characterization. O'Bryan, M.K., Baker, H.W., Saunders, J.R., Kirszbaum, L., Walker, I.D., Hudson, P., Liu, D.Y., Glew, M.D., d'Apice, A.J., Murphy, B.F. J. Clin. Invest. (1990)