Disease relevance of BC2385

• Inactivation of glucose 6-phosphate dehydrogenase during germination and outgrowth of Bacillus cereus T endospores [1].

High impact information on BC2385

• Mixing experiments show no inhibitor of glucose 6-phosphate dehydrogenase to be present in late-stage cells [1].
• Chloramphenicol and rifampicine immediately stop protein synthesis and development but not the inactivation of glucose 6-phosphate dehydrogenase [1].
• The membrane respiratory activity of intact B. cereus cells (as measured by the triphenyl tetrazolium reduction) and the succinic dehydrogenase activity of B. subtilis isolated membranes were found to be inhibited by the four local anesthetics [2].
• In contrast to the high capability of detaching Caco-2 cells shown by all the strains under study, the mitochondrial dehydrogenase activity was lowered by culture filtrate supernatants in a strain-dependent manner [3].
• This report describes a toxicity testing procedure using the inhibition of dehydrogenase enzyme activity of Bacillus cereus as test parameter [4].

Biological context of BC2385

• IMP dehydrogenase activity of B. cereus increased parallel to cell growth in YE-EMM, where B. cereus did not sporulate [5].

References