Gene Review:
LRRK2 - leucine-rich repeat kinase 2
Homo sapiens
Synonyms:
AURA17, DARDARIN, DKFZp434H2111, Dardarin, FLJ45829, ...
- LRRK2 gene in Parkinson disease: mutation analysis and case control association study. Paisán-Ruíz, C., Lang, A.E., Kawarai, T., Sato, C., Salehi-Rad, S., Fisman, G.K., Al-Khairallah, T., St George-Hyslop, P., Singleton, A., Rogaeva, E. Neurology (2005)
- Mutations in LRRK2 cause autosomal-dominant parkinsonism with pleomorphic pathology. Zimprich, A., Biskup, S., Leitner, P., Lichtner, P., Farrer, M., Lincoln, S., Kachergus, J., Hulihan, M., Uitti, R.J., Calne, D.B., Stoessl, A.J., Pfeiffer, R.F., Patenge, N., Carbajal, I.C., Vieregge, P., Asmus, F., Müller-Myhsok, B., Dickson, D.W., Meitinger, T., Strom, T.M., Wszolek, Z.K., Gasser, T. Neuron (2004)
- Comprehensive analysis of the LRRK2 gene in sixty families with Parkinson's disease. Di Fonzo, A., Tassorelli, C., De Mari, M., Chien, H.F., Ferreira, J., Rohé, C.F., Riboldazzi, G., Antonini, A., Albani, G., Mauro, A., Marconi, R., Abbruzzese, G., Lopiano, L., Fincati, E., Guidi, M., Marini, P., Stocchi, F., Onofrj, M., Toni, V., Tinazzi, M., Fabbrini, G., Lamberti, P., Vanacore, N., Meco, G., Leitner, P., Uitti, R.J., Wszolek, Z.K., Gasser, T., Simons, E.J., Breedveld, G.J., Goldwurm, S., Pezzoli, G., Sampaio, C., Barbosa, E., Martignoni, E., Oostra, B.A., Bonifati, V. Eur. J. Hum. Genet. (2006)
- Parkinson's disease and LRRK2: Frequency of a common mutation in U.S. movement disorder clinics. Kay, D.M., Zabetian, C.P., Factor, S.A., Nutt, J.G., Samii, A., Griffith, A., Bird, T.D., Kramer, P., Higgins, D.S., Payami, H. Mov. Disord. (2006)
- LRRK2 mutations are not common in Alzheimer's disease. Toft, M., Sando, S.B., Melquist, S., Ross, O.A., White, L.R., Aasly, J.O., Farrer, M.J. Mech. Ageing Dev. (2005)
- LRRK2 in Parkinson's disease: protein domains and functional insights. Mata, I.F., Wedemeyer, W.J., Farrer, M.J., Taylor, J.P., Gallo, K.A. Trends Neurosci. (2006)
- Altered alpha-synuclein homeostasis causing Parkinson's disease: the potential roles of dardarin. Singleton, A.B. Trends Neurosci. (2005)
- The Familial Parkinsonism Gene LRRK2 Regulates Neurite Process Morphology. Macleod, D., Dowman, J., Hammond, R., Leete, T., Inoue, K., Abeliovich, A. Neuron (2006)
- Role of autophagy in G2019S-LRRK2-associated neurite shortening in differentiated SH-SY5Y cells. Plowey, E.D., Cherra SJ, 3.r.d., Liu, Y.J., Chu, C.T. J. Neurochem. (2008)
- Mutant LRRK2 elicits calcium imbalance and depletion of dendritic mitochondria in neurons. Cherra SJ, 3.r.d., Steer, E., Gusdon, A.M., Kiselyov, K., Chu, C.T. Am. J. Pathol. (2013)
- Lrrk2 pathogenic substitutions in Parkinson's disease. Mata, I.F., Kachergus, J.M., Taylor, J.P., Lincoln, S., Aasly, J., Lynch, T., Hulihan, M.M., Cobb, S.A., Wu, R.M., Lu, C.S., Lahoz, C., Wszolek, Z.K., Farrer, M.J. Neurogenetics (2005)
- LRRK2 G2019S in Families with Parkinson Disease Who Originated from Europe and the Middle East: Evidence of Two Distinct Founding Events Beginning Two Millennia Ago. Zabetian, C.P., Hutter, C.M., Yearout, D., Lopez, A.N., Factor, S.A., Griffith, A., Leis, B.C., Bird, T.D., Nutt, J.G., Higgins, D.S., Roberts, J.W., Kay, D.M., Edwards, K.L., Samii, A., Payami, H. Am. J. Hum. Genet. (2006)
- Clinicogenetic study of mutations in LRRK2 exon 41 in Parkinson's disease patients from 18 countries. Tomiyama, H., Li, Y., Funayama, M., Hasegawa, K., Yoshino, H., Kubo, S., Sato, K., Hattori, T., Lu, C.S., Inzelberg, R., Djaldetti, R., Melamed, E., Amouri, R., Gouider-Khouja, N., Hentati, F., Hatano, Y., Wang, M., Imamichi, Y., Mizoguchi, K., Miyajima, H., Obata, F., Toda, T., Farrer, M.J., Mizuno, Y., Hattori, N. Mov. Disord. (2006)
- Striatal dopamine transporter binding in Parkinson's disease associated with the LRRK2 Gly2019Ser mutation. Isaias, I.U., Benti, R., Goldwurm, S., Zini, M., Cilia, R., Gerundini, P., Di Fonzo, A., Bonifati, V., Pezzoli, G., Antonini, A. Mov. Disord. (2006)
- Pathophysiology, pleiotrophy and paradigm shifts: genetic lessons from Parkinson's disease. Ross, O.A., Farrer, M.J. Biochem. Soc. Trans. (2005)
- Identification of a novel LRRK2 mutation linked to autosomal dominant parkinsonism: evidence of a common founder across European populations. Kachergus, J., Mata, I.F., Hulihan, M., Taylor, J.P., Lincoln, S., Aasly, J., Gibson, J.M., Ross, O.A., Lynch, T., Wiley, J., Payami, H., Nutt, J., Maraganore, D.M., Czyzewski, K., Styczynska, M., Wszolek, Z.K., Farrer, M.J., Toft, M. Am. J. Hum. Genet. (2005)
- Parkinson's disease-associated mutations in leucine-rich repeat kinase 2 augment kinase activity. West, A.B., Moore, D.J., Biskup, S., Bugayenko, A., Smith, W.W., Ross, C.A., Dawson, V.L., Dawson, T.M. Proc. Natl. Acad. Sci. U.S.A. (2005)
- Comprehensive evaluation of common genetic variation within LRRK2 reveals evidence for association with sporadic Parkinson's disease. Skipper, L., Li, Y., Bonnard, C., Pavanni, R., Yih, Y., Chua, E., Sung, W.K., Tan, L., Wong, M.C., Tan, E.K., Liu, J. Hum. Mol. Genet. (2005)
- An LRRK2 mutation as a cause for the parkinsonism in the original PARK8 family. Funayama, M., Hasegawa, K., Ohta, E., Kawashima, N., Komiyama, M., Kowa, H., Tsuji, S., Obata, F. Ann. Neurol. (2005)
- LRRK2 expression linked to dopamine-innervated areas. Galter, D., Westerlund, M., Carmine, A., Lindqvist, E., Sydow, O., Olson, L. Ann. Neurol. (2006)
- Localization of LRRK2 to membranous and vesicular structures in mammalian brain. Biskup, S., Moore, D.J., Celsi, F., Higashi, S., West, A.B., Andrabi, S.A., Kurkinen, K., Yu, S.W., Savitt, J.M., Waldvogel, H.J., Faull, R.L., Emson, P.C., Torp, R., Ottersen, O.P., Dawson, T.M., Dawson, V.L. Ann. Neurol. (2006)
- Leucine-rich repeat kinase 2 (LRRK2) interacts with parkin, and mutant LRRK2 induces neuronal degeneration. Smith, W.W., Pei, Z., Jiang, H., Moore, D.J., Liang, Y., West, A.B., Dawson, V.L., Dawson, T.M., Ross, C.A. Proc. Natl. Acad. Sci. U.S.A. (2005)
- Protein kinases linked to the pathogenesis of Parkinson's disease. Shen, J. Neuron (2004)
- GTP Binding Is Essential to the Protein Kinase Activity of LRRK2, a Causative Gene Product for Familial Parkinson's Disease. Ito, G., Okai, T., Fujino, G., Takeda, K., Ichijo, H., Katada, T., Iwatsubo, T. Biochemistry (2007)
- Progress in familial Parkinson's disease. Mizuno, Y., Hattori, N., Yoshino, H., Hatano, Y., Satoh, K., Tomiyama, H., Li, Y. J. Neural Transm. Suppl. (2006)
- Common variants of LRRK2 are not associated with sporadic Parkinson's disease. Biskup, S., Mueller, J.C., Sharma, M., Lichtner, P., Zimprich, A., Berg, D., Wüllner, U., Illig, T., Meitinger, T., Gasser, T. Ann. Neurol. (2005)
- LRRK2 Expression in Normal and Pathologic Human Brain and in Human Cell Lines. Miklossy, J., Arai, T., Guo, J.P., Klegeris, A., Yu, S., McGeer, E.G., McGeer, P.L. J. Neuropathol. Exp. Neurol. (2006)
- Genetics of Parkinson's disease. Gasser, T. Curr. Opin. Neurol. (2005)
- The Parkinson disease causing LRRK2 mutation I2020T is associated with increased kinase activity. Gloeckner, C.J., Kinkl, N., Schumacher, A., Braun, R.J., O'Neill, E., Meitinger, T., Kolch, W., Prokisch, H., Ueffing, M. Hum. Mol. Genet. (2006)
- Clinical and positron emission tomography of Parkinson's disease caused by LRRK2. Hernandez, D.G., Paisán-Ruíz, C., McInerney-Leo, A., Jain, S., Meyer-Lindenberg, A., Evans, E.W., Berman, K.F., Johnson, J., Auburger, G., Schäffer, A.A., Lopez, G.J., Nussbaum, R.L., Singleton, A.B. Ann. Neurol. (2005)
- A frequent LRRK2 gene mutation associated with autosomal dominant Parkinson's disease. Di Fonzo, A., Rohé, C.F., Ferreira, J., Chien, H.F., Vacca, L., Stocchi, F., Guedes, L., Fabrizio, E., Manfredi, M., Vanacore, N., Goldwurm, S., Breedveld, G., Sampaio, C., Meco, G., Barbosa, E., Oostra, B.A., Bonifati, V. Lancet (2005)
- Analysis of LRRK2 functional domains in nondominant Parkinson disease. Skipper, L., Shen, H., Chua, E., Bonnard, C., Kolatkar, P., Tan, L.C., Jamora, R.D., Puvan, K., Puong, K.Y., Zhao, Y., Pavanni, R., Wong, M.C., Yuen, Y., Farrer, M., Liu, J.J., Tan, E.K. Neurology (2005)