Gene Review:
Brca1 - breast cancer 1
Mus musculus
Synonyms:
Breast cancer type 1 susceptibility protein homolog
Xu,
Aprelikova,
Moens,
Deng,
Furth,
McAllister,
Wiseman,
Maehr,
Uskokovic,
Adorini,
Penna,
Mariani,
Panina,
Passini,
Bono,
Perego,
Biffi,
Holick,
Spina,
Suh,
Bennett,
McAllister,
Malphurs,
Ward,
Collins,
Seely,
Gowen,
Koller,
Davis,
Wiseman,
Turner,
Mahadevaiah,
Fernandez-Capetillo,
Nussenzweig,
Xu,
Deng,
Burgoyne,
- Collaboration of Brca1 and Chk2 in tumorigenesis. McPherson, J.P., Lemmers, B., Hirao, A., Hakem, A., Abraham, J., Migon, E., Matysiak-Zablocki, E., Tamblyn, L., Sanchez-Sweatman, O., Khokha, R., Squire, J., Hande, M.P., Mak, T.W., Hakem, R. Genes Dev. (2004)
- Uterus hyperplasia and increased carcinogen-induced tumorigenesis in mice carrying a targeted mutation of the Chk2 phosphorylation site in Brca1. Kim, S.S., Cao, L., Li, C., Xu, X., Huber, L.J., Chodosh, L.A., Deng, C.X. Mol. Cell. Biol. (2004)
- A mouse model for the molecular characterization of brca1-associated ovarian carcinoma. Xing, D., Orsulic, S. Cancer Res. (2006)
- Hypersensitivity of Brca1-deficient MEF to the DNA interstrand crosslinking agent mitomycin C is associated with defect in homologous recombination repair and aberrant S-phase arrest. Yun, J., Zhong, Q., Kwak, J.Y., Lee, W.H. Oncogene (2005)
- ATM-Chk2-p53 activation prevents tumorigenesis at an expense of organ homeostasis upon Brca1 deficiency. Cao, L., Kim, S., Xiao, C., Wang, R.H., Coumoul, X., Wang, X., Li, W.M., Xu, X.L., De Soto, J.A., Takai, H., Mai, S., Elledge, S.J., Motoyama, N., Deng, C.X. EMBO J. (2006)
- Silencing of unsynapsed meiotic chromosomes in the mouse. Turner, J.M., Mahadevaiah, S.K., Fernandez-Capetillo, O., Nussenzweig, A., Xu, X., Deng, C.X., Burgoyne, P.S. Nat. Genet. (2005)
- Genetic interactions between tumor suppressors Brca1 and p53 in apoptosis, cell cycle and tumorigenesis. Xu, X., Qiao, W., Linke, S.P., Cao, L., Li, W.M., Furth, P.A., Harris, C.C., Deng, C.X. Nat. Genet. (2001)
- Conditional mutation of Brca1 in mammary epithelial cells results in blunted ductal morphogenesis and tumour formation. Xu, X., Wagner, K.U., Larson, D., Weaver, Z., Li, C., Ried, T., Hennighausen, L., Wynshaw-Boris, A., Deng, C.X. Nat. Genet. (1999)
- Partial rescue of Brca1 (5-6) early embryonic lethality by p53 or p21 null mutation. Hakem, R., de la Pompa, J.L., Elia, A., Potter, J., Mak, T.W. Nat. Genet. (1997)
- Promotion of mammary cancer development by tamoxifen in a mouse model of Brca1-mutation-related breast cancer. Jones, L.P., Li, M., Halama, E.D., Ma, Y., Lubet, R., Grubbs, C.J., Deng, C.X., Rosen, E.M., Furth, P.A. Oncogene (2005)
- Calcitriol derivatives with two different side chains at C-20 III. An epimeric pair of the gemini family with unprecedented antiproliferative effects on tumor cells and renin mRNA expression inhibition. Maehr, H., Uskokovic, M., Adorini, L., Penna, G., Mariani, R., Panina, P., Passini, N., Bono, E., Perego, S., Biffi, M., Holick, M., Spina, C., Suh, N. J. Steroid Biochem. Mol. Biol. (2007)
- Inhibition of indoleamine 2,3-dioxygenase in dendritic cells by stereoisomers of 1-methyl-tryptophan correlates with antitumor responses. Hou, D.Y., Muller, A.J., Sharma, M.D., DuHadaway, J., Banerjee, T., Johnson, M., Mellor, A.L., Prendergast, G.C., Munn, D.H. Cancer Res. (2007)
- Inhibition of bone resorption, rather than direct cytotoxicity, mediates the anti-tumour actions of ibandronate and osteoprotegerin in a murine model of breast cancer bone metastasis. Zheng, Y., Zhou, H., Brennan, K., Blair, J.M., Modzelewski, J.R., Seibel, M.J., Dunstan, C.R. Bone (2007)
- The tumor suppressor gene Brca1 is required for embryonic cellular proliferation in the mouse. Hakem, R., de la Pompa, J.L., Sirard, C., Mo, R., Woo, M., Hakem, A., Wakeham, A., Potter, J., Reitmair, A., Billia, F., Firpo, E., Hui, C.C., Roberts, J., Rossant, J., Mak, T.W. Cell (1996)
- Targeted mutations of breast cancer susceptibility gene homologs in mice: lethal phenotypes of Brca1, Brca2, Brca1/Brca2, Brca1/p53, and Brca2/p53 nullizygous embryos. Ludwig, T., Chapman, D.L., Papaioannou, V.E., Efstratiadis, A. Genes Dev. (1997)
- Brca2 is required for embryonic cellular proliferation in the mouse. Suzuki, A., de la Pompa, J.L., Hakem, R., Elia, A., Yoshida, R., Mo, R., Nishina, H., Chuang, T., Wakeham, A., Itie, A., Koo, W., Billia, P., Ho, A., Fukumoto, M., Hui, C.C., Mak, T.W. Genes Dev. (1997)
- Brcal required for T cell lineage development but not TCR loci rearrangement. Mak, T.W., Hakem, A., McPherson, J.P., Shehabeldin, A., Zablocki, E., Migon, E., Duncan, G.S., Bouchard, D., Wakeham, A., Cheung, A., Karaskova, J., Sarosi, I., Squire, J., Marth, J., Hakem, R. Nat. Immunol. (2000)
- Impaired meiotic DNA-damage repair and lack of crossing-over during spermatogenesis in BRCA1 full-length isoform deficient mice. Xu, X., Aprelikova, O., Moens, P., Deng, C.X., Furth, P.A. Development (2003)
- Brca1 and Brca2 expression patterns in mitotic and meiotic cells of mice. Blackshear, P.E., Goldsworthy, S.M., Foley, J.F., McAllister, K.A., Bennett, L.M., Collins, N.K., Bunch, D.O., Brown, P., Wiseman, R.W., Davis, B.J. Oncogene (1998)
- Effects of Novel Retinoic Acid Metabolism Blocking Agent (VN/14-1) on Letrozole-Insensitive Breast Cancer Cells. Belosay, A., Brodie, A.M., Njar, V.C. Cancer Res. (2006)
- Environmental carcinogens and p53 tumor-suppressor gene interactions in a transgenic mouse model for mammary carcinogenesis. Medina, D., Ullrich, R., Meyn, R., Wiseman, R., Donehower, L. Environ. Mol. Mutagen. (2002)
- The effect of loss of Brca1 on the sensitivity to anticancer agents in p53-deficient cells. Fedier, A., Steiner, R.A., Schwarz, V.A., Lenherr, L., Haller, U., Fink, D. Int. J. Oncol. (2003)
- Prevention of Brca1-mediated mammary tumorigenesis in mice by a progesterone antagonist. Poole, A.J., Li, Y., Kim, Y., Lin, S.C., Lee, W.H., Lee, E.Y. Science (2006)
- Mice heterozygous for a Brca1 or Brca2 mutation display distinct mammary gland and ovarian phenotypes in response to diethylstilbestrol. Bennett, L.M., McAllister, K.A., Malphurs, J., Ward, T., Collins, N.K., Seely, J.C., Gowen, L.C., Koller, B.H., Davis, B.J., Wiseman, R.W. Cancer Res. (2000)
- Are Trp53 rescue of Brca1 embryonic lethality and Trp53/Brca1 breast cancer association related? McAllister, K.A., Wiseman, R.W. Breast Cancer Res. (2002)
- BRCA1 facilitates microhomology-mediated end joining of DNA double strand breaks. Zhong, Q., Chen, C.F., Chen, P.L., Lee, W.H. J. Biol. Chem. (2002)
- The breast cancer susceptibility gene BRCA1 is required for subnuclear assembly of Rad51 and survival following treatment with the DNA cross-linking agent cisplatin. Bhattacharyya, A., Ear, U.S., Koller, B.H., Weichselbaum, R.R., Bishop, D.K. J. Biol. Chem. (2000)
- Stable Knockdown of Estrogen Receptor alpha by Vector-Based RNA Interference Suppresses Proliferation and Enhances Apoptosis in Breast Cancer Cells. Fu, H.J., Jia, L.T., Bao, W., Zhao, J., Meng, Y.L., Wang, C.J., Yao, L.B., Chen, S.Y., Yang, A.G. Cancer Biol. Ther. (2006)
- Snail in the frame of malignant tumor recurrence. De Craene, B., Berx, G. Breast Cancer Res. (2006)
- Laminin-rich extracellular matrix association with mammary epithelial cells suppresses Brca1 expression. O'Connell, F.C., Martin, F. Cell Death Differ. (2000)
- Loss of Bard1, the heterodimeric partner of the Brca1 tumor suppressor, results in early embryonic lethality and chromosomal instability. McCarthy, E.E., Celebi, J.T., Baer, R., Ludwig, T. Mol. Cell. Biol. (2003)
- Steroid Receptor Coactivator-3 and Activator Protein-1 Coordinately Regulate the Transcription of Components of the Insulin-Like Growth Factor/AKT Signaling Pathway. Yan, J., Yu, C.T., Ozen, M., Ittmann, M., Tsai, S.Y., Tsai, M.J. Cancer Res. (2006)
- A targeted mouse Brca1 mutation removing the last BRCT repeat results in apoptosis and embryonic lethality at the headfold stage. Hohenstein, P., Kielman, M.F., Breukel, C., Bennett, L.M., Wiseman, R., Krimpenfort, P., Cornelisse, C., van Ommen, G.J., Devilee, P., Fodde, R. Oncogene (2001)
- Role of the tumor suppressor gene Brca1 in genetic stability and mammary gland tumor formation. Deng, C.X., Scott, F. Oncogene (2000)
- Brca1 and Brca2 protein expression patterns in different tissues of murine origin. Bernard-Gallon, D.J., De Latour, M.P., Sylvain, V., Vissac, C., Aunoble, B., Chassagne, J., Bignon, Y.J. Int. J. Oncol. (2001)
- Mouse Brca1: localization sequence analysis and identification of evolutionarily conserved domains. Abel, K.J., Xu, J., Yin, G.Y., Lyons, R.H., Meisler, M.H., Weber, B.L. Hum. Mol. Genet. (1995)
- Homology-directed dna repair, mitomycin-c resistance, and chromosome stability is restored with correction of a Brca1 mutation. Moynahan, M.E., Cui, T.Y., Jasin, M. Cancer Res. (2001)