Disease relevance of Ddr1

• Identification of two isoforms of the Cak receptor kinase that are coexpressed in breast tumor cell lines [1].

High impact information on Ddr1

• Cak II protein was not detected in mouse embryos or adult tissues, but is abundantly expressed in some breast tumor cell lines [1].
• The coexpression of the Cak isoforms in some epithelial cell lines suggests that heterodimer formation may be a key feature in the function of the receptor [1].
• By RNase protection analyses, we found that the long isoform, Cak I is expressed at three- to sevenfold the abundance of the short isoform (Cak II) [1].
• The cell adhesion kinase (Cak) is expressed at low levels in most adult tissues and expression is highest in the brain and lung [2].
• Using fluorescence in situ hybridization and interspecific backcross mapping, the Cak gene was localized to human chromosome 6 and mouse chromosome 17 [2].

Analytical, diagnostic and therapeutic context of Ddr1

• By Western blotting, Cak I receptor was found to be expressed in mouse embryos and in adult brain [1].

References