Gene Review:
CCR4 - chemokine (C-C motif) receptor 4
Homo sapiens
Synonyms:
C-C CKR-4, C-C chemokine receptor type 4, CC-CKR-4, CCR-4, CD194, ...
Sallusto,
Lenig,
Mackay,
Lanzavecchia,
Panina-Bordignon,
Papi,
Mariani,
Di Lucia,
Casoni,
Bellettato,
Buonsanti,
Miotto,
Mapp,
Villa,
Arrigoni,
Fabbri,
Sinigaglia,
Scala,
Guerra,
Giani,
Pirrotta,
Locanto,
Mondino,
Mari,
Rottman,
Smith,
Ganley,
Kikuchi,
Krueger,
Fricker,
Anastassov,
Cox,
Darkes,
Grujic,
Idzan,
Labrecque,
Lau,
Mosi,
Nelson,
Qin,
Santucci,
Wong,
Thompson,
Luyrink,
Graham,
Tsoras,
Ryan,
Passo,
Glass,
Kobayashi,
Shimauchi,
Hino,
Tokura,
Campbell,
Haraldsen,
Pan,
Rottman,
Qin,
Ponath,
Andrew,
Warnke,
Ruffing,
Kassam,
Wu,
Butcher,
Lloyd,
Delaney,
Nguyen,
Tian,
Martinez-A,
Coyle,
Gutierrez-Ramos,
Clemetson,
Clemetson,
Proudfoot,
Power,
Baggiolini,
Wells,
Nureki,
Miyazaki,
Ando,
Kumamoto,
Tsuda,
Yoshie,
Fujisawa,
Nakayama,
Harasawa,
Tago,
Izawa,
Hieshima,
Tatsumi,
Matsushima,
Hasegawa,
Kanamaru,
Kamihira,
Yamada,
- Frequent expression of CCR4 in adult T-cell leukemia and human T-cell leukemia virus type 1-transformed T cells. Yoshie, O., Fujisawa, R., Nakayama, T., Harasawa, H., Tago, H., Izawa, D., Hieshima, K., Tatsumi, Y., Matsushima, K., Hasegawa, H., Kanamaru, A., Kamihira, S., Yamada, Y. Blood (2002)
- Expression and function of chemokine receptors on human thymocytes: implications for infection by human immunodeficiency virus type 1. Taylor, J.R., Kimbrell, K.C., Scoggins, R., Delaney, M., Wu, L., Camerini, D. J. Virol. (2001)
- Chemokine receptor expression on neoplastic and reactive T cells in the skin at different stages of mycosis fungoides. Kallinich, T., Muche, J.M., Qin, S., Sterry, W., Audring, H., Kroczek, R.A. J. Invest. Dermatol. (2003)
- Increased CCR4 expression in cutaneous T cell lymphoma. Ferenczi, K., Fuhlbrigge, R.C., Pinkus, J., Pinkus, G.S., Kupper, T.S. J. Invest. Dermatol. (2002)
- The chemokine receptor CCR4 in vascular recognition by cutaneous but not intestinal memory T cells. Campbell, J.J., Haraldsen, G., Pan, J., Rottman, J., Qin, S., Ponath, P., Andrew, D.P., Warnke, R., Ruffing, N., Kassam, N., Wu, L., Butcher, E.C. Nature (1999)
- Unique chemotactic response profile and specific expression of chemokine receptors CCR4 and CCR8 by CD4(+)CD25(+) regulatory T cells. Iellem, A., Mariani, M., Lang, R., Recalde, H., Panina-Bordignon, P., Sinigaglia, F., D'Ambrosio, D. J. Exp. Med. (2001)
- CC chemokine receptor (CCR)3/eotaxin is followed by CCR4/monocyte-derived chemokine in mediating pulmonary T helper lymphocyte type 2 recruitment after serial antigen challenge in vivo. Lloyd, C.M., Delaney, T., Nguyen, T., Tian, J., Martinez-A, C., Coyle, A.J., Gutierrez-Ramos, J.C. J. Exp. Med. (2000)
- Potential role of the chemokine receptors CXCR3, CCR4, and the integrin alphaEbeta7 in the pathogenesis of psoriasis vulgaris. Rottman, J.B., Smith, T.L., Ganley, K.G., Kikuchi, T., Krueger, J.G. Lab. Invest. (2001)
- Role of the chemokine receptors CXCR3 and CCR4 in human pulmonary fibrosis. Pignatti, P., Brunetti, G., Moretto, D., Yacoub, M.R., Fiori, M., Balbi, B., Balestrino, A., Cervio, G., Nava, S., Moscato, G. Am. J. Respir. Crit. Care Med. (2006)
- Delayed allergic reaction to suxamethonium driven by oligoclonal Th1-skewed CD4+CCR4+IFN-gamma+ memory T cells. Scala, E., Guerra, E.C., Giani, M., Pirrotta, L., Locanto, M., Mondino, C., Mari, A. Int. Arch. Allergy Immunol. (2006)
- Allogeneic peripheral blood stem cell transplantation with CD34+-cell selection and delayed T-cell add-back in adults. Results of a single center pilot study. Martino, R., Martín-Henao, G., Sureda, A., Altés, A., Canals, C., Brunet, S., Sierra, J. Haematologica (2000)
- CD34+ selected autologous peripheral blood stem cell transplantation for multiple sclerosis: report of toxicity and treatment results at one year of follow-up in 15 patients. Carreras, E., Saiz, A., Marín, P., Martínez, C., Rovira, M., Villamor, N., Aymerich, M., Lozano, M., Fernández-Avilés, F., Urbano-Izpizua, A., Montserrat, E., Graus, F. Haematologica (2003)
- Activation of phosphoinositide 3-kinases by the CCR4 ligand macrophage-derived chemokine is a dispensable signal for T lymphocyte chemotaxis. Cronshaw, D.G., Owen, C., Brown, Z., Ward, S.G. J. Immunol. (2004)
- BTG2 antiproliferative protein interacts with the human CCR4 complex existing in vivo in three cell-cycle-regulated forms. Morel, A.P., Sentis, S., Bianchin, C., Le Romancer, M., Jonard, L., Rostan, M.C., Rimokh, R., Corbo, L. J. Cell. Sci. (2003)
- CCR8-dependent activation of the RAS/MAPK pathway mediates anti-apoptotic activity of I-309/ CCL1 and vMIP-I. Louahed, J., Struyf, S., Demoulin, J.B., Parmentier, M., Van Snick, J., Van Damme, J., Renauld, J.C. Eur. J. Immunol. (2003)
- The genes encoding the human CC-chemokine receptors CC-CKR1 to CC-CKR5 (CMKBR1-CMKBR5) are clustered in the p21.3-p24 region of chromosome 3. Samson, M., Soularue, P., Vassart, G., Parmentier, M. Genomics (1996)
- Chemokine receptor CCR4 on CD4+ T cells in juvenile rheumatoid arthritis synovial fluid defines a subset of cells with increased IL-4:IFN-gamma mRNA ratios. Thompson, S.D., Luyrink, L.K., Graham, T.B., Tsoras, M., Ryan, M., Passo, M.H., Glass, D.N. J. Immunol. (2001)
- The C-C chemokine receptors CCR4 and CCR8 identify airway T cells of allergen-challenged atopic asthmatics. Panina-Bordignon, P., Papi, A., Mariani, M., Di Lucia, P., Casoni, G., Bellettato, C., Buonsanti, C., Miotto, D., Mapp, C., Villa, A., Arrigoni, G., Fabbri, L.M., Sinigaglia, F. J. Clin. Invest. (2001)
- Functional expression of CCR1, CCR3, CCR4, and CXCR4 chemokine receptors on human platelets. Clemetson, K.J., Clemetson, J.M., Proudfoot, A.E., Power, C.A., Baggiolini, M., Wells, T.N. Blood (2000)
- Evidence that phospholipase-C-dependent, calcium-independent mechanisms are required for directional migration of T-lymphocytes in response to the CCR4 ligands CCL17 and CCL22. Cronshaw, D.G., Kouroumalis, A., Parry, R., Webb, A., Brown, Z., Ward, S.G. J. Leukoc. Biol. (2006)
- Characterization of the molecular pharmacology of AMD3100: a specific antagonist of the G-protein coupled chemokine receptor, CXCR4. Fricker, S.P., Anastassov, V., Cox, J., Darkes, M.C., Grujic, O., Idzan, S.R., Labrecque, J., Lau, G., Mosi, R.M., Nelson, K.L., Qin, L., Santucci, Z., Wong, R.S. Biochem. Pharmacol. (2006)
- Involvement of Th1 cells and heat shock protein 60 in the pathogenesis of intestinal Behcet's disease. Imamura, Y., Kurokawa, M.S., Yoshikawa, H., Nara, K., Takada, E., Masuda, C., Tsukikawa, S., Ozaki, S., Matsuda, T., Suzuki, N. Clin. Exp. Immunol. (2005)
- Pivotal role of TARC, a CC chemokine, in bacteria-induced fulminant hepatic failure in mice. Yoneyama, H., Harada, A., Imai, T., Baba, M., Yoshie, O., Zhang, Y., Higashi, H., Murai, M., Asakura, H., Matsushima, K. J. Clin. Invest. (1998)
- Structures of thymus and activation-regulated chemokine (TARC). Asojo, O.A., Boulègue, C., Hoover, D.M., Lu, W., Lubkowski, J. Acta Crystallogr. D Biol. Crystallogr. (2003)
- Profile of human macrophage transcripts: insights into macrophage biology and identification of novel chemokines. Chantry, D., DeMaggio, A.J., Brammer, H., Raport, C.J., Wood, C.L., Schweickart, V.L., Epp, A., Smith, A., Stine, J.T., Walton, K., Tjoelker, L., Godiska, R., Gray, P.W. J. Leukoc. Biol. (1998)
- CCR4 ligands are up-regulated in the airways of atopic asthmatics after segmental allergen challenge. Pilette, C., Francis, J.N., Till, S.J., Durham, S.R. Eur. Respir. J. (2004)
- The T cell-directed CC chemokine TARC is a highly specific biological ligand for CC chemokine receptor 4. Imai, T., Baba, M., Nishimura, M., Kakizaki, M., Takagi, S., Yoshie, O. J. Biol. Chem. (1997)
- CC chemokine receptor 4 ligand production by bronchoalveolar lavage fluid cells in cigarette-smoke-associated acute eosinophilic pneumonia. Nureki, S., Miyazaki, E., Ando, M., Kumamoto, T., Tsuda, T. Clin. Immunol. (2005)
- Roxithromycin downmodulates Th2 chemokine production by keratinocytes and chemokine receptor expression on Th2 cells: its dual inhibitory effects on the ligands and the receptors. Kobayashi, M., Shimauchi, T., Hino, R., Tokura, Y. Cell. Immunol. (2004)
- Clonal Th2 cells associated with chronic hypereosinophilia: TARC-induced CCR4 down-regulation in vivo. de Lavareille, A., Roufosse, F., Schandené, L., Stordeur, P., Cogan, E., Goldman, M. Eur. J. Immunol. (2001)
- Flexible programs of chemokine receptor expression on human polarized T helper 1 and 2 lymphocytes. Sallusto, F., Lenig, D., Mackay, C.R., Lanzavecchia, A. J. Exp. Med. (1998)
- Human NK cells express CC chemokine receptors 4 and 8 and respond to thymus and activation-regulated chemokine, macrophage-derived chemokine, and I-309. Inngjerdingen, M., Damaj, B., Maghazachi, A.A. J. Immunol. (2000)
- Release of both CCR4-active and CXCR3-active chemokines during human allergic pulmonary late-phase reactions. Bochner, B.S., Hudson, S.A., Xiao, H.Q., Liu, M.C. J. Allergy Clin. Immunol. (2003)
- Macrophage-derived chemokine induces human eosinophil chemotaxis in a CC chemokine receptor 3- and CC chemokine receptor 4-independent manner. Bochner, B.S., Bickel, C.A., Taylor, M.L., MacGlashan, D.W., Gray, P.W., Raport, C.J., Godiska, R. J. Allergy Clin. Immunol. (1999)
- Selective infiltration of CCR5(+)CXCR3(+) T lymphocytes in human colorectal carcinoma. Musha, H., Ohtani, H., Mizoi, T., Kinouchi, M., Nakayama, T., Shiiba, K., Miyagawa, K., Nagura, H., Yoshie, O., Sasaki, I. Int. J. Cancer (2005)
- Multiple determinants are involved in HIV coreceptor use as demonstrated by CCR4/CCL22 interaction in peripheral blood mononuclear cells (PBMCs). Agrawal, L., Vanhorn-Ali, Z., Alkhatib, G. J. Leukoc. Biol. (2002)
- Accumulation of CCR4-expressing CD4+ T cells and high concentration of its ligands (TARC and MDC) in bronchoalveolar lavage fluid of patients with eosinophilic pneumonia. Katoh, S., Fukushima, K., Matsumoto, N., Matsumoto, K., Abe, K., Onai, N., Matsushima, K., Matsukura, S. Allergy (2003)