Gene Review:
CCR5 - chemokine (C-C motif) receptor 5...
Homo sapiens
Synonyms:
C-C CKR-5, C-C chemokine receptor type 5, CC-CKR-5, CCCKR5, CCR-5, ...
Garred,
Laue,
Richardson,
Lanzavecchia,
Lessie,
Snyderman,
Lohmann,
Hoofnagle,
Kapellen,
Nietzschmann,
Wang,
Price,
Paschke,
Ditzel,
Heller,
Lehmann,
Sallusto,
Rosenkilde,
Sata,
Kleiner,
Alter,
Lee,
Kiess,
Keane,
French,
Oppermann,
Schwartz,
Schroeder,
Soza,
McDermott,
Gonzalez,
Gorry,
Promrat,
Burton,
Polzer,
Murphy,
Koefoed,
Merrell,
Lenig,
Liang,
Ghany,
Schreiber,
Gray,
Tokunaga,
Mackay,
Pedersen,
Marjoram,
Thordsen,
Koziol,
Park,
- The beta-chemokine receptors CCR3 and CCR5 facilitate infection by primary HIV-1 isolates. Choe, H., Farzan, M., Sun, Y., Sullivan, N., Rollins, B., Ponath, P.D., Wu, L., Mackay, C.R., LaRosa, G., Newman, W., Gerard, N., Gerard, C., Sodroski, J. Cell (1996)
- The role of CCR5 and CCR2 polymorphisms in HIV-1 transmission and disease progression. Michael, N.L., Louie, L.G., Rohrbaugh, A.L., Schultz, K.A., Dayhoff, D.E., Wang, C.E., Sheppard, H.W. Nat. Med. (1997)
- A broad-spectrum chemokine antagonist encoded by Kaposi's sarcoma-associated herpesvirus. Kledal, T.N., Rosenkilde, M.M., Coulin, F., Simmons, G., Johnsen, A.H., Alouani, S., Power, C.A., Lüttichau, H.R., Gerstoft, J., Clapham, P.R., Clark-Lewis, I., Wells, T.N., Schwartz, T.W. Science (1997)
- The B-oligomer of pertussis toxin deactivates CC chemokine receptor 5 and blocks entry of M-tropic HIV-1 strains. Alfano, M., Schmidtmayerova, H., Amella, C.A., Pushkarsky, T., Bukrinsky, M. J. Exp. Med. (1999)
- Associations of chemokine system polymorphisms with clinical outcomes and treatment responses of chronic hepatitis C. Promrat, K., McDermott, D.H., Gonzalez, C.M., Kleiner, D.E., Koziol, D.E., Lessie, M., Merrell, M., Soza, A., Heller, T., Ghany, M., Park, Y., Alter, H.J., Hoofnagle, J.H., Murphy, P.M., Liang, T.J. Gastroenterology (2003)
- Microglia express CCR5, CXCR4, and CCR3, but of these, CCR5 is the principal coreceptor for human immunodeficiency virus type 1 dementia isolates. Albright, A.V., Shieh, J.T., Itoh, T., Lee, B., Pleasure, D., O'Connor, M.J., Doms, R.W., González-Scarano, F. J. Virol. (1999)
- Characterization of the role of the N-loop of MIP-1 beta in CCR5 binding. Bondue, A., Jao, S.C., Blanpain, C., Parmentier, M., LiWang, P.J. Biochemistry (2002)
- Brief Report: CXCR4 or CCR5 Tropism of Human Immunodeficiency Virus Type 1 Isolates Does Not Determine the Immunological Milieu in Patients Responding to Antiretroviral Therapy. Price, P., Keane, N., Gray, L., Lee, S., Gorry, P.R., French, M.A. Viral Immunol. (2006)
- Infection of cells expressing CXCR4 mutants lacking N-glycosylation at the N-terminal extracellular domain is enhanced for R5X4-dualtropic human immunodeficiency virus type-1. Thordsen, I., Polzer, S., Schreiber, M. BMC Infect. Dis. (2002)
- The CCR5 receptor acts as an alloantigen in CCR5Delta32 homozygous individuals: identification of chemokineand HIV-1-blocking human antibodies. Ditzel, H.J., Rosenkilde, M.M., Garred, P., Wang, M., Koefoed, K., Pedersen, C., Burton, D.R., Schwartz, T.W. Proc. Natl. Acad. Sci. U.S.A. (1998)
- Tyrosine sulfation of human antibodies contributes to recognition of the CCR5 binding region of HIV-1 gp120. Choe, H., Li, W., Wright, P.L., Vasilieva, N., Venturi, M., Huang, C.C., Grundner, C., Dorfman, T., Zwick, M.B., Wang, L., Rosenberg, E.S., Kwong, P.D., Burton, D.R., Robinson, J.E., Sodroski, J.G., Farzan, M. Cell (2003)
- The extent of genetic variation in the CCR5 gene. Ansari-Lari, M.A., Liu, X.M., Metzker, M.L., Rut, A.R., Gibbs, R.A. Nat. Genet. (1997)
- A dual-tropic primary HIV-1 isolate that uses fusin and the beta-chemokine receptors CKR-5, CKR-3, and CKR-2b as fusion cofactors. Doranz, B.J., Rucker, J., Yi, Y., Smyth, R.J., Samson, M., Peiper, S.C., Parmentier, M., Collman, R.G., Doms, R.W. Cell (1996)
- Tyrosine sulfation of CCR5 N-terminal peptide by tyrosylprotein sulfotransferases 1 and 2 follows a discrete pattern and temporal sequence. Seibert, C., Cadene, M., Sanfiz, A., Chait, B.T., Sakmar, T.P. Proc. Natl. Acad. Sci. U.S.A. (2002)
- Patterns of chemokine receptor expression on peripheral blood gamma delta T lymphocytes: strong expression of CCR5 is a selective feature of V delta 2/V gamma 9 gamma delta T cells. Glatzel, A., Wesch, D., Schiemann, F., Brandt, E., Janssen, O., Kabelitz, D. J. Immunol. (2002)
- Human Mast cell progenitors can be infected by macrophagetropic human immunodeficiency virus type 1 and retain virus with maturation in vitro. Bannert, N., Farzan, M., Friend, D.S., Ochi, H., Price, K.S., Sodroski, J., Boyce, J.A. J. Virol. (2001)
- Inhibition of human immunodeficiency virus replication by a dual CCR5/CXCR4 antagonist. Princen, K., Hatse, S., Vermeire, K., Aquaro, S., De Clercq, E., Gerlach, L.O., Rosenkilde, M., Schwartz, T.W., Skerlj, R., Bridger, G., Schols, D. J. Virol. (2004)
- Genealogy of the CCR5 locus and chemokine system gene variants associated with altered rates of HIV-1 disease progression. Mummidi, S., Ahuja, S.S., Gonzalez, E., Anderson, S.A., Santiago, E.N., Stephan, K.T., Craig, F.E., O'Connell, P., Tryon, V., Clark, R.A., Dolan, M.J., Ahuja, S.K. Nat. Med. (1998)
- Potent inhibition of HIV-1 infectivity in macrophages and lymphocytes by a novel CCR5 antagonist. Simmons, G., Clapham, P.R., Picard, L., Offord, R.E., Rosenkilde, M.M., Schwartz, T.W., Buser, R., Wells, T.N., Proudfoot, A.E. Science (1997)
- HIV coreceptor downregulation as antiviral principle: SDF-1alpha-dependent internalization of the chemokine receptor CXCR4 contributes to inhibition of HIV replication. Amara, A., Gall, S.L., Schwartz, O., Salamero, J., Montes, M., Loetscher, P., Baggiolini, M., Virelizier, J.L., Arenzana-Seisdedos, F. J. Exp. Med. (1997)
- In vivo evolution of HIV-1 co-receptor usage and sensitivity to chemokine-mediated suppression. Scarlatti, G., Tresoldi, E., Björndal, A., Fredriksson, R., Colognesi, C., Deng, H.K., Malnati, M.S., Plebani, A., Siccardi, A.G., Littman, D.R., Fenyö, E.M., Lusso, P. Nat. Med. (1997)
- CCR3 and CCR5 are co-receptors for HIV-1 infection of microglia. He, J., Chen, Y., Farzan, M., Choe, H., Ohagen, A., Gartner, S., Busciglio, J., Yang, X., Hofmann, W., Newman, W., Mackay, C.R., Sodroski, J., Gabuzda, D. Nature (1997)
- A small-molecule, nonpeptide CCR5 antagonist with highly potent and selective anti-HIV-1 activity. Baba, M., Nishimura, O., Kanzaki, N., Okamoto, M., Sawada, H., Iizawa, Y., Shiraishi, M., Aramaki, Y., Okonogi, K., Ogawa, Y., Meguro, K., Fujino, M. Proc. Natl. Acad. Sci. U.S.A. (1999)
- Redox regulation of chemokine receptor expression. Saccani, A., Saccani, S., Orlando, S., Sironi, M., Bernasconi, S., Ghezzi, P., Mantovani, A., Sica, A. Proc. Natl. Acad. Sci. U.S.A. (2000)
- A potential immune escape mechanism by melanoma cells through the activation of chemokine-induced T cell death. Mellado, M., de Ana, A.M., Moreno, M.C., Martínez, C., Rodríguez-Frade, J.M. Curr. Biol. (2001)
- Interaction of soluble CD4 with the chemokine receptor CCR5. Wang, X., Staudinger, R. Biochem. Biophys. Res. Commun. (2003)
- G protein-coupled receptor kinases promote phosphorylation and beta-arrestin-mediated internalization of CCR5 homo- and hetero-oligomers. Hüttenrauch, F., Pollok-Kopp, B., Oppermann, M. J. Biol. Chem. (2005)
- Chemokine receptor CCR5: insights into structure, function, and regulation. Oppermann, M. Cell. Signal. (2004)
- Activation of the chemotactic peptide receptor FPRL1 in monocytes phosphorylates the chemokine receptor CCR5 and attenuates cell responses to selected chemokines. Shen, W., Proost, P., Li, B., Gong, W., Le, Y., Sargeant, R., Murphy, P.M., Van Damme, J., Wang, J.M. Biochem. Biophys. Res. Commun. (2000)
- Reduced expression of Th1-associated chemokine receptors on peripheral blood lymphocytes at diagnosis of type 1 diabetes. Lohmann, T., Laue, S., Nietzschmann, U., Kapellen, T.M., Lehmann, I., Schroeder, S., Paschke, R., Kiess, W. Diabetes (2002)
- CCR1+/CCR5+ mononuclear phagocytes accumulate in the central nervous system of patients with multiple sclerosis. Trebst, C., Sørensen, T.L., Kivisäkk, P., Cathcart, M.K., Hesselgesser, J., Horuk, R., Sellebjerg, F., Lassmann, H., Ransohoff, R.M. Am. J. Pathol. (2001)
- HIV-1 Tat induces monocyte chemoattractant protein-1-mediated monocyte transmigration across a model of the human blood-brain barrier and up-regulates CCR5 expression on human monocytes. Weiss, J.M., Nath, A., Major, E.O., Berman, J.W. J. Immunol. (1999)
- Interleukin-8-mediated heterologous receptor internalization provides resistance to HIV-1 infectivity. Role of signal strength and receptor desensitization. Richardson, R.M., Tokunaga, K., Marjoram, R., Sata, T., Snyderman, R. J. Biol. Chem. (2003)
- Differential regulation of CXCR4 and CCR5 endocytosis. Signoret, N., Rosenkilde, M.M., Klasse, P.J., Schwartz, T.W., Malim, M.H., Hoxie, J.A., Marsh, M. J. Cell. Sci. (1998)
- Porphyromonas gingivalis selectively up-regulates the HIV-1 coreceptor CCR5 in oral keratinocytes. Giacaman, R.A., Nobbs, A.H., Ross, K.F., Herzberg, M.C. J. Immunol. (2007)
- Flexible programs of chemokine receptor expression on human polarized T helper 1 and 2 lymphocytes. Sallusto, F., Lenig, D., Mackay, C.R., Lanzavecchia, A. J. Exp. Med. (1998)
- Natural proteolytic processing of hemofiltrate CC chemokine 1 generates a potent CC chemokine receptor (CCR)1 and CCR5 agonist with anti-HIV properties. Detheux, M., Ständker, L., Vakili, J., Münch, J., Forssmann, U., Adermann, K., Pöhlmann, S., Vassart, G., Kirchhoff, F., Parmentier, M., Forssmann, W.G. J. Exp. Med. (2000)
- Lineage-specific expression of human immunodeficiency virus (HIV) receptor/coreceptors in differentiating hematopoietic precursors: correlation with susceptibility to T- and M-tropic HIV and chemokine-mediated HIV resistance. Chelucci, C., Casella, I., Federico, M., Testa, U., Macioce, G., Pelosi, E., Guerriero, R., Mariani, G., Giampaolo, A., Hassan, H.J., Peschle, C. Blood (1999)
- Molecular cloning and functional characterization of a novel human CC chemokine receptor (CCR5) for RANTES, MIP-1beta, and MIP-1alpha. Raport, C.J., Gosling, J., Schweickart, V.L., Gray, P.W., Charo, I.F. J. Biol. Chem. (1996)
- Early reduction of immune activation in lymphoid tissue following highly active HIV therapy. Andersson, J., Fehniger, T.E., Patterson, B.K., Pottage, J., Agnoli, M., Jones, P., Behbahani, H., Landay, A. AIDS (1998)
- Distribution of chemokine receptor CCR2 and CCR5 genotypes and their relative contribution to human immunodeficiency virus type 1 (HIV-1) seroconversion, early HIV-1 RNA concentration in plasma, and later disease progression. Tang, J., Shelton, B., Makhatadze, N.J., Zhang, Y., Schaen, M., Louie, L.G., Goedert, J.J., Seaberg, E.C., Margolick, J.B., Mellors, J., Kaslow, R.A. J. Virol. (2002)