Gene Review:
Cd247 - CD247 antigen
Mus musculus
Synonyms:
4930549J05Rik, A430104F18Rik, AW552088, CD3 zeta, CD3-eta, ...
- The single positive T cells found in CD3-zeta/eta-/- mice overtly react with self-major histocompatibility complex molecules upon restoration of normal surface density of T cell receptor-CD3 complex. Lin, S.Y., Ardouin, L., Gillet, A., Malissen, M., Malissen, B. J. Exp. Med. (1997)
- T cells from late tumor-bearing mice express normal levels of p56lck, p59fyn, ZAP-70, and CD3 zeta despite suppressed cytolytic activity. Levey, D.L., Srivastava, P.K. J. Exp. Med. (1995)
- Variable expression of CD3-zeta chain in tumor-infiltrating lymphocytes (TIL) derived from renal-cell carcinoma: relationship with TIL phenotype and function. Tartour, E., Latour, S., Mathiot, C., Thiounn, N., Mosseri, V., Joyeux, I., D'Enghien, C.D., Lee, R., Debre, B., Fridman, W.H. Int. J. Cancer (1995)
- Correlation between disease activity and T-cell CD3 zeta chain expression in a B-cell lymphoma. Massaia, M., Attisano, C., Beggiato, E., Bianchi, A., Pileri, A. Br. J. Haematol. (1994)
- L-arginine consumption by macrophages modulates the expression of CD3 zeta chain in T lymphocytes. Rodriguez, P.C., Zea, A.H., DeSalvo, J., Culotta, K.S., Zabaleta, J., Quiceno, D.G., Ochoa, J.B., Ochoa, A.C. J. Immunol. (2003)
- The T cell receptor/CD3 complex is composed of at least two autonomous transduction modules. Wegener, A.M., Letourneur, F., Hoeveler, A., Brocker, T., Luton, F., Malissen, B. Cell (1992)
- Failure to synthesize the T cell CD3-zeta chain: structure and function of a partial T cell receptor complex. Sussman, J.J., Bonifacino, J.S., Lippincott-Schwartz, J., Weissman, A.M., Saito, T., Klausner, R.D., Ashwell, J.D. Cell (1988)
- CD3delta couples T-cell receptor signalling to ERK activation and thymocyte positive selection. Delgado, P., Fernández, E., Dave, V., Kappes, D., Alarcón, B. Nature (2000)
- Combined natural killer cell and dendritic cell functional deficiency in KARAP/DAP12 loss-of-function mutant mice. Tomasello, E., Desmoulins, P.O., Chemin, K., Guia, S., Cremer, H., Ortaldo, J., Love, P., Kaiserlian, D., Vivier, E. Immunity (2000)
- Developmental arrest of NK1.1+ T cell antigen receptor (TCR)-alpha/beta+ T cells and expansion of NK1.1+ TCR-gamma/delta+ T cell development in CD3 zeta-deficient mice. Arase, H., Ono, S., Arase, N., Park, S.Y., Wakizaka, K., Watanabe, H., Ohno, H., Saito, T. J. Exp. Med. (1995)
- Targeted disruption of the CD3 eta locus causes high lethality in mice: modulation of Oct-1 transcription on the opposite strand. Ohno, H., Goto, S., Taki, S., Shirasawa, T., Nakano, H., Miyatake, S., Aoe, T., Ishida, Y., Maeda, H., Shirai, T. EMBO J. (1994)
- Molecular cloning of the CD3 eta subunit identifies a CD3 zeta-related product in thymus-derived cells. Jin, Y.J., Clayton, L.K., Howard, F.D., Koyasu, S., Sieh, M., Steinbrich, R., Tarr, G.E., Reinherz, E.L. Proc. Natl. Acad. Sci. U.S.A. (1990)
- T cell receptor complexes containing Fc epsilon RI gamma homodimers in lieu of CD3 zeta and CD3 eta components: a novel isoform expressed on large granular lymphocytes. Koyasu, S., D'Adamio, L., Arulanandam, A.R., Abraham, S., Clayton, L.K., Reinherz, E.L. J. Exp. Med. (1992)
- Abnormal T cell development in CD3-zeta-/- mutant mice and identification of a novel T cell population in the intestine. Liu, C.P., Ueda, R., She, J., Sancho, J., Wang, B., Weddell, G., Loring, J., Kurahara, C., Dudley, E.C., Hayday, A. EMBO J. (1993)
- Negative regulation of expression and function of Fc gamma RIII by CD3 zeta in murine NK cells. Arase, H., Suenaga, T., Arase, N., Kimura, Y., Ito, K., Shiina, R., Ohno, H., Saito, T. J. Immunol. (2001)
- T cell CD3-zeta eta heterodimer expression and coupling to phosphoinositide hydrolysis. Merćep, M., Bonifacino, J.S., Garcia-Morales, P., Samelson, L.E., Klausner, R.D., Ashwell, J.D. Science (1988)
- Involvement of a metalloprotease in spontaneous and phorbol ester-induced release of natural killer cell-associated Fc gamma RIII (CD16-II). Harrison, D., Phillips, J.H., Lanier, L.L. J. Immunol. (1991)
- Transmembrane domain of CD44 is required for its detergent insolubility in fibroblasts. Perschl, A., Lesley, J., English, N., Hyman, R., Trowbridge, I.S. J. Cell. Sci. (1995)
- Multiple survival signals are delivered by dendritic cells to naive CD4+ T cells. Feuillet, V., Lucas, B., Di Santo, J.P., Bismuth, G., Trautmann, A. Eur. J. Immunol. (2005)
- Defective recruitment and activation of ZAP-70 in common variable immunodeficiency patients with T cell defects. Boncristiano, M., Majolini, M.B., D'Elios, M.M., Pacini, S., Valensin, S., Ulivieri, C., Amedei, A., Falini, B., Del Prete, G., Telford, J.L., Baldari, C.T. Eur. J. Immunol. (2000)
- Regulation of T cell receptor (TCR) beta gene expression by CD3 complex signaling in immature thymocytes: implications for TCRbeta allelic exclusion. Biro, J., Würch, A., Potocnik, A.J., Falk, I., Mossmann, H., Eichmann, K. Proc. Natl. Acad. Sci. U.S.A. (1999)
- Influence on CD8 of TCR/CD3-generated signals in CTL clones and CTL precursor cells. Anel, A., Martínez-Lorenzo, M.J., Schmitt-Verhulst, A.M., Boyer, C. J. Immunol. (1997)
- Generation of antigen-specific cytotoxic T lymphocytes and regulation of cytokine production takes place in the absence of CD3zeta. She, J., Ruzek, M.C., Velupillai, P., de Aos, I., Wang, B., Harn, D.A., Sancho, J., Biron, C.A., Terhorst, C. Int. Immunol. (1999)
- Development of CD4-CD8- alpha beta TCR+NK1.1+ T lymphocytes: thymic selection by self antigen. Schulz, R.J., Parkes, A., Mizoguchi, E., Bhan, A.K., Koyasu, S. J. Immunol. (1996)
- Rat class III Fc gamma receptor isoforms differ in IgG subclass-binding specificity and fail to associate productively with rat CD3 zeta. Farber, D.L., Giorda, R., Nettleton, M.Y., Trucco, M., Kochan, J.P., Sears, D.W. J. Immunol. (1993)
- Differential signal transduction via T-cell receptor CD3 zeta 2, CD3 zeta-eta, and CD3 eta 2 isoforms. Bauer, A., McConkey, D.J., Howard, F.D., Clayton, L.K., Novick, D., Koyasu, S., Reinherz, E.L. Proc. Natl. Acad. Sci. U.S.A. (1991)
- Development and function of T cells in T cell antigen receptor/CD3 zeta knockout mice reconstituted with Fc epsilon RI gamma. Liu, C.P., Lin, W.J., Huang, M., Kappler, J.W., Marrack, P. Proc. Natl. Acad. Sci. U.S.A. (1997)
- Differential Src family kinase activity requirements for CD3 zeta phosphorylation/ZAP70 recruitment and CD3 epsilon phosphorylation. Lysechko, T.L., Ostergaard, H.L. J. Immunol. (2005)
- Expression and selection of productively rearranged TCR beta VDJ genes are sequentially regulated by CD3 signaling in the development of NK1.1(+) alpha beta T cells. Baur, N., Nerz, G., Nil, A., Eichmann, K. Int. Immunol. (2001)
- Increased Zap-70 association with CD3zeta in CD4 T cells from old mice. Garcia, G.G., Miller, R.A. Cell. Immunol. (1998)
- Developmental and functional impairment of T cells in mice lacking CD3 zeta chains. Ohno, H., Aoe, T., Taki, S., Kitamura, D., Ishida, Y., Rajewsky, K., Saito, T. EMBO J. (1993)
- Architectural changes in the TCR:CD3 complex induced by MHC:peptide ligation. La Gruta, N.L., Liu, H., Dilioglou, S., Rhodes, M., Wiest, D.L., Vignali, D.A. J. Immunol. (2004)
- T cell receptor-independent CD2 signal transduction in FcR+ cells. Arulanandam, A.R., Koyasu, S., Reinherz, E.L. J. Exp. Med. (1991)
- Reconstitution of CD3 zeta coupling to calcium mobilization via genetic complementation. Donnadieu, E., Trautmann, A., Malissen, M., Trucy, J., Malissen, B., Vivier, E. J. Biol. Chem. (1994)