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Gene Review

Cdc25b  -  cell division cycle 25B

Mus musculus

Synonyms: AI604853, Cdc25m2, Dual specificity phosphatase Cdc25B, M-phase inducer phosphatase 2
 
 
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High impact information on Cdc25b

  • Microinjection of wildtype Cdc25b mRNA into Cdc25b-/- oocytes caused activation of MPF and resumption of meiosis [1].
  • Female Cdc25b-/- mice were sterile, and Cdc25b-/- oocytes remained arrested at prophase with low MPF activity [1].
  • As compared with wildtype cells, fibroblasts from Cdc25b-/- mice grew vigorously in culture and arrested normally in response to DNA damage [1].
  • Although proliferating transgenic hepatocytes induced by either PH or CCl(4) liver injury displayed early expression of identical M-phase cyclin genes (cyclin B1, B2, A2, and F), only CCl(4) regenerating transgenic liver exhibited earlier expression of the M-phase promoting Cdc25b [2].
  • These studies suggest that CCl(4) injury of transgenic liver not only uses the same mechanisms as PH to mediate accelerated hepatocyte entry into mitosis, but also promotes M-phase entry by stimulating Cdc25b expression [2].
 

Biological context of Cdc25b

References

  1. Cdc25b phosphatase is required for resumption of meiosis during oocyte maturation. Lincoln, A.J., Wickramasinghe, D., Stein, P., Schultz, R.M., Palko, M.E., De Miguel, M.P., Tessarollo, L., Donovan, P.J. Nat. Genet. (2002) [Pubmed]
  2. Earlier expression of the transcription factor HFH-11B diminishes induction of p21(CIP1/WAF1) levels and accelerates mouse hepatocyte entry into S-phase following carbon tetrachloride liver injury. Wang, X., Hung, N.J., Costa, R.H. Hepatology (2001) [Pubmed]
 
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