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Gene Review

hoc  -  highly immunogenic supplemental capsid...

Enterobacteria phage T4

 
 
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Disease relevance of hoc

  • Hexamers of the major capsid protein gene product (gp)23* and pentamers of the vertex protein gp24*, as well as the outer surface proteins highly antigenic outer capsid protein (hoc) and small outer capsid protein (soc), are clearly evident in the reconstruction [1].
  • Evidence that bacteriophage T4 eph1 is a missense hoc mutation [2].
  • Thus, it is likely that during infection of E. coli with the eph1 strain, a hoc protein is made that has a lower negative charge than normal hoc protein but can nevertheless bind to particles lacking hoc protein [2].
  • Cloning of linear DNAs in vivo by overexpressed T4 DNA ligase: construction of a T4 phage hoc gene display vector [3].
 

High impact information on hoc

  • Post hoc t tests were used to further explore the relationships between serum TSH and global CBF and cerebral glucose metabolism [4].
  • Effects of megestrol acetate on pituitary function and end-organ hormone secretion: a post hoc analysis of serum samples from a 12-week study in healthy older men [5].
 

Biological context of hoc

  • The binding sites and shape of the hoc and soc proteins have been established by analysis of the soc(-) and hoc(-)soc(-) T4 structures [1].
  • The T4 phage capsid accessory protein genes soc and hoc have recently been developed for display of peptides and protein domains at high copy number (Ren et al., 1996. Protein Science 5, 1833-1843; Ren et al., 1997. Gene 195, 303-311) [6].

References

  1. Molecular architecture of the prolate head of bacteriophage T4. Fokine, A., Chipman, P.R., Leiman, P.G., Mesyanzhinov, V.V., Rao, V.B., Rossmann, M.G. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
  2. Evidence that bacteriophage T4 eph1 is a missense hoc mutation. Childs, J.D., Pilon, R. J. Virol. (1983) [Pubmed]
  3. Cloning of linear DNAs in vivo by overexpressed T4 DNA ligase: construction of a T4 phage hoc gene display vector. Ren, Z.J., Baumann, R.G., Black, L.W. Gene (1997) [Pubmed]
  4. Inverse relationship of peripheral thyrotropin-stimulating hormone levels to brain activity in mood disorders. Marangell, L.B., Ketter, T.A., George, M.S., Pazzaglia, P.J., Callahan, A.M., Parekh, P., Andreason, P.J., Horwitz, B., Herscovitch, P., Post, R.M. The American journal of psychiatry. (1997) [Pubmed]
  5. Effects of megestrol acetate on pituitary function and end-organ hormone secretion: a post hoc analysis of serum samples from a 12-week study in healthy older men. Bodenner, D.L., Medhi, M., Evans, W.J., Sullivan, D.H., Liu, H., Lambert, C.P. The American journal of geriatric pharmacotherapy. (2005) [Pubmed]
  6. Phage T4 SOC and HOC display of biologically active, full-length proteins on the viral capsid. Ren, Z., Black, L.W. Gene (1998) [Pubmed]
 
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