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Gene Review

CALR3  -  calreticulin 3

Homo sapiens

 
 
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Disease relevance of CALR3

  • Using the dot-blot method, we were able to detect C. rectus using the CRT-2 antibody when as few as 103 organisms were present in a subgingival dental plaque sample [1].
  • CRT2 was identified as a new cancer-testis antigen expressed in elongated spermatids of testis and in cancer tissues (particularly melanoma) that is recognized by serum IgG from cancer patients [2].
 

High impact information on CALR3

  • Translation of the CRT2 coding sequence reveals a new protein with regions of perfect homology with the CRT1 amino-acid sequence [3].

References

  1. Detection of Campylobacter rectus in periodontitis sites by monoclonal antibodies. Ihara, H., Miura, T., Kato, T., Ishihara, K., Nakagawa, T., Yamada, S., Okuda, K. J. Periodont. Res. (2003) [Pubmed]
  2. Identification of a novel cancer-testis antigen CRT2 frequently expressed in various cancers using representational differential analysis. Hayashi, E., Matsuzaki, Y., Hasegawa, G., Yaguchi, T., Kurihara, S., Fujita, T., Kageshita, T., Sano, M., Kawakami, Y. Clin. Cancer Res. (2007) [Pubmed]
  3. Cloning and sequencing of a cDNA encoding a novel member of the human brain GABA/noradrenaline neurotransmitter transporter family. Barnwell, L.F., Chaudhuri, G., Townsel, J.G. Gene (1995) [Pubmed]
 
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