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ACER1  -  alkaline ceramidase 1

Homo sapiens

Synonyms: ALKCDase1, ASAH3, Acylsphingosine deacylase 3, AlkCDase 1, Alkaline CDase 1, ...
 
 
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Disease relevance of ASAH3

 

High impact information on ASAH3

  • Starch biosynthesis has been studied by using amyloplasts isolated from cultured cells of sycamore trees (Acer pseudoplatanus L.). Highly purified intact amyloplasts, free from mitochondria and starch granules derived from broken amyloplasts, were isolated from a Percoll step gradient [3].
  • The LONI Pipeline Processing Environment's parallel processing efficiency using an integrated client/server dataflow model was 80.9% when running the atlas generation pipeline from a PC client (Acer TravelMate 340T) on 48 dedicated server processors (Silicon Graphics Inc. Origin 3000) [4].
  • The synthesis of malate and citrate by sycamore cells (Acer pseudoplatanus L.) perfused with KH13CO3 was analyzed using 13C NMR [5].
  • O2-triggered changes of membrane fatty acid composition have no effect on Arrhenius discontinuities of respiration in sycamore (Acer pseudoplatanus L.) cells [6].
  • Transformation of plastids in the leaves of Acer negundo L. var. odessanum (H. Rothe) [7].
 

Chemical compound and disease context of ASAH3

  • Bioassay-directed chromatographic fractionation of an ethyl acetate extract of the leaves of Acer okamotoanum using HIV-1 integrase afforded a new acylated flavonol glycoside, quercetin 3-O-(2",6"-O-digalloyl)-beta-D-galactopyranoside (1), together with six known flavonol glycosides and three known phenolic compounds [2].
 

Biological context of ASAH3

  • Nucleotide sequence of a cDNA clone encoding an acidic laccase from sycamore maple (Acer pseudoplatanus L.) [8].
  • Protein phosphorylation in intact cultured sycamore (Acer pseudoplatanus) cells and its response to fusicoccin [9].
  • Is the availability of substrate for the tricarboxylic acid cycle a limiting factor for uncoupled respiration in sycamore (Acer pseudoplatanus) cells [10]?
  • The theoretical analyses were validated by making use of a computer simulation study and their utility is demonstrated by analyzing microsatellite marker data collected from two populations of sycamore maple (Acer pseudoplatanus L.), an economically important autotetraploid tree species [11].
  • Acid phosphatase of sycamore (Acer pseudoplatanus) cell walls is a monomeric enzyme that displays classical Michaelis-Menten kinetics in free solution [12].
 

Anatomical context of ASAH3

  • Transcription of amyloplast DNA in a heterotrophic line of cultured cells of sycamore (Acer pseudoplatanus L.) appeared to be greatly suppressed [13].
  • The relation between xylem vessel age and vulnerability to cavitation of sugar maple (Acer saccharum Marsh.) was quantified by measuring the pressure required to force air across bordered pit membranes separating individual xylem vessels [14].
  • To this end, we have employed a combination of electron microscopical, immunocytochemical, and biochemical techniques to investigate the effects of this drug on the architecture of the Golgi apparatus as well as on the secretion of proteins and complex cell wall polysaccharides in sycamore maple (Acer pseudoplatanus) suspension-cultured cells [15].
  • Protoplasts obtained from sycamore (Acer pseudoplatanus) cell suspensions were found to be highly intact and to retain a high rate of O2 consumption [10].
  • Structurally intact and metabolically competent mitochondria isolated from liquid-culture cells of sycamore (Acer pseudoplatanus L.) were shown to incorporate ADPglucose [16].
 

Associations of ASAH3 with chemical compounds

  • Synchronous divisions have been induced in cell suspension cultures of sycamore (Acer pseudoplatanus L.) initiated at low density from stationary phase, nitrate-starved cells [17].
  • The decline of sugar maples (Acer saccharum) [18].
  • Effect of brefeldin A on the structure of the Golgi apparatus and on the synthesis and secretion of proteins and polysaccharides in sycamore maple (Acer pseudoplatanus) suspension-cultured cells [15].
  • Effect of sucrose starvation on sycamore (Acer pseudoplatanus) cell carbohydrate and Pi status [19].
  • Biosynthesis of glycoproteins by membranes of Acer pseudoplatanus. Incorporation of mannose and N-acetylglucosamine [20].
 

Analytical, diagnostic and therapeutic context of ASAH3

References

  1. Maxillary sinusitis caused by Pleurophomopsis lignicola. Padhye, A.A., Gutekunst, R.W., Smith, D.J., Punithalingam, E. J. Clin. Microbiol. (1997) [Pubmed]
  2. A new flavonol glycoside gallate ester from Acer okamotoanum and its inhibitory activity against human immunodeficiency virus-1 (HIV-1) integrase. Kim, H.J., Woo, E.R., Shin, C.G., Park, H. J. Nat. Prod. (1998) [Pubmed]
  3. Direct transport of ADPglucose by an adenylate translocator is linked to starch biosynthesis in amyloplasts. Pozueta-Romero, J., Frehner, M., Viale, A.M., Akazawa, T. Proc. Natl. Acad. Sci. U.S.A. (1991) [Pubmed]
  4. The LONI Pipeline Processing Environment. Rex, D.E., Ma, J.Q., Toga, A.W. Neuroimage (2003) [Pubmed]
  5. 13C nuclear magnetic resonance studies of malate and citrate synthesis and compartmentation in higher plant cells. Gout, E., Bligny, R., Pascal, N., Douce, R. J. Biol. Chem. (1993) [Pubmed]
  6. O2-triggered changes of membrane fatty acid composition have no effect on Arrhenius discontinuities of respiration in sycamore (Acer pseudoplatanus L.) cells. Bligny, R., Rebeillé, F., Douce, R. J. Biol. Chem. (1985) [Pubmed]
  7. Transformation of plastids in the leaves of Acer negundo L. var. odessanum (H. Rothe). Wrischer, M., Ljubesić, N., Dividé, Z. J. Cell. Sci. (1975) [Pubmed]
  8. Nucleotide sequence of a cDNA clone encoding an acidic laccase from sycamore maple (Acer pseudoplatanus L.). LaFayette, P.R., Eriksson, K.E., Dean, J.F. Plant Physiol. (1995) [Pubmed]
  9. Protein phosphorylation in intact cultured sycamore (Acer pseudoplatanus) cells and its response to fusicoccin. Tognoli, L., Colombo, R. Biochem. J. (1986) [Pubmed]
  10. Is the availability of substrate for the tricarboxylic acid cycle a limiting factor for uncoupled respiration in sycamore (Acer pseudoplatanus) cells? Journet, E.P., Bligny, R., Douce, R. Biochem. J. (1986) [Pubmed]
  11. Modeling population genetic data in autotetraploid species. Luo, Z.W., Zhang, Z., Zhang, R.M., Pandey, M., Gailing, O., Hattemer, H.H., Finkeldey, R. Genetics (2006) [Pubmed]
  12. Ionic control of immobilized enzymes. Kinetics of acid phosphatase bound to plant cell walls. Ricard, J., Noat, G., Crasnier, M., Job, D. Biochem. J. (1981) [Pubmed]
  13. DNA methylation as a mechanism of transcriptional regulation in nonphotosynthetic plastids in plant cells. Ngernprasirtsiri, J., Kobayashi, H., Akazawa, T. Proc. Natl. Acad. Sci. U.S.A. (1988) [Pubmed]
  14. Vulnerability of xylem vessels to cavitation in sugar maple. Scaling from individual vessels to whole branches. Melcher, P.J., Zwieniecki, M.A., Holbrook, N.M. Plant Physiol. (2003) [Pubmed]
  15. Effect of brefeldin A on the structure of the Golgi apparatus and on the synthesis and secretion of proteins and polysaccharides in sycamore maple (Acer pseudoplatanus) suspension-cultured cells. Driouich, A., Zhang, G.F., Staehelin, L.A. Plant Physiol. (1993) [Pubmed]
  16. Comparative analysis of mitochondrial and amyloplast adenylate translocators. Pozueta-Romero, J., Viale, A.M., Akazawa, T. FEBS Lett. (1991) [Pubmed]
  17. Kinetic aspects of synchrony in suspension cultures of Acer pseudoplatanus L. Gould, A.R., Street, H.E. J. Cell. Sci. (1975) [Pubmed]
  18. The decline of sugar maples (Acer saccharum). Minorsky, P.V. Plant Physiol. (2003) [Pubmed]
  19. Effect of sucrose starvation on sycamore (Acer pseudoplatanus) cell carbohydrate and Pi status. Rébeillé, F., Bligny, R., Martin, J.B., Douce, R. Biochem. J. (1985) [Pubmed]
  20. Biosynthesis of glycoproteins by membranes of Acer pseudoplatanus. Incorporation of mannose and N-acetylglucosamine. Barr, J., Nordin, P. Biochem. J. (1980) [Pubmed]
  21. Induction of tolerance to desiccation and cryopreservation in silver maple (Acer saccharinum) embryonic axes. Beardmore, T., Whittle, C.A. Tree Physiol. (2005) [Pubmed]
  22. Oligonucleotide DNA fingerprinting detects a multiallelic locus in box elder (Acer negundo). Nybom, H., Ramser, J., Kaemmer, D., Kahl, G., Weising, K. Mol. Ecol. (1992) [Pubmed]
  23. Golgi-specific localization of transglycosylases engaged in glycoprotein biosynthesis in suspension-cultured cells of sycamore (Acer pseudoplatanus L.). Ali, M.S., Mitsui, T., Akazawa, T. Arch. Biochem. Biophys. (1986) [Pubmed]
  24. Filtering centrifugation through two layers of silicone oil: a method for the kinetic analysis of rapid metabolite transport in organelles. Pozueta-Romero, J., Frehner, M., Akazawa, T. Cell Struct. Funct. (1991) [Pubmed]
 
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